J. E. Dumont

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Pairs of cyclic AMP analogs, that are specifically synergistic for type I and type II cAMP-dependent protein kinases, mimic thyrotropin effects on the function, differentiation expression and mitogenesis of dog thyroid cells.

J. Dumont, J. Corbin, P. Roger, 1989, European journal of biochemistry.

Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis.

J. Dumont, C. Maenhaut, P. Roger, 2010, Carcinogenesis.

The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor.

M. Parmentier, J. Vanderhaeghen, J. Dumont, 1991, The EMBO journal.

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity.

S Schiffmann, G Vassart, F Libert, 1990, Biochemical and biophysical research communications.

Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.

J. Dumont, R. Stein, F. Vandeput, 2000, The Biochemical journal.

Sphingolipid-cholesterol domains (lipid rafts) in normal human and dog thyroid follicular cells are not involved in thyrotropin receptor signaling.

J. Dumont, S. Costagliola, Y. Song, 2004, Endocrinology.

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.

P. Rocmans, J. Parma, J. Hermans, 1997, The Journal of clinical endocrinology and metabolism.

Molecular cloning of the thyrotropin receptor.

M. Parmentier, J. Dumont, C. Maenhaut, 1989, Science.

Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture.

J. Dumont, P. Roger, S. Reuse, 1986, Cancer research.

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

J. Dumont, F. Lamy, P. Roger, 1993, The Journal of biological chemistry.

Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells.

S. Swillens, J. Dumont, S. Costagliola, 2003, The Journal of clinical endocrinology and metabolism.

Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia.

S. Swillens, F. Cetani, J. Parma, 1996, The Journal of clinical endocrinology and metabolism.

Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.

J. Bos, J. Dumont, F. Vandeput, 2000, Biochemical and biophysical research communications.

The Role of Cyclic AMP and Its Effect on Protein Kinase A in the Mitogenic Action of Thyrotropin on the Thyroid Cell

S. Schurmans, C. Ledent, J. Dumont, 2002, Annals of the New York Academy of Sciences.

Human thyrotropin receptor gene: Expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation

G. Brabant, J. Köhrle, J. Dumont, 1991, Molecular and Cellular Endocrinology.

Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein.

S. Swillens, J. Dumont, S. Costagliola, 1992, The Journal of clinical endocrinology and metabolism.

Potential role of Noxes in the protection of mucosae: H(2)O(2) as a bacterial repellent.

J. Sande, A. Botteaux, A. Allaoui, 2009, Microbes and infection.

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Ming‐Fei Hsu, B. Viollet, D. Vertommen, 2016, Nature Communications.

The TSH cyclic AMP cascade in the control of thyroid cell proliferation: the story of a concept.

C. Maenhaut, M. Taton, Marc Parmentier, 1991, Thyroidology.

Cell biology of H2O2 generation in the thyroid: Investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines

J. Dumont, A. Virion, J. Ruf, 2011, Molecular and Cellular Endocrinology.

Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

J. Bartek, J. Dumont, I. Pirson, 2000, Molecular biology of the cell.

Thyroid adenocarcinomas secondary to tissue-specific expression of simian virus-40 large T-antigen in transgenic mice.

M. Parmentier, C. Ledent, J. Dumont, 1991, Endocrinology.

The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid.

E. Laurent, J. Dumont, B. Corvilain, 1991, Endocrinology.

Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase.

J. Vandekerckhove, J. Dumont, C. Erneux, 1990, The Biochemical journal.

Somatic and germline mutations of the TSH receptor gene in thyroid diseases.

S. Swillens, J. Parma, M. Tonacchera, 1995, The Journal of clinical endocrinology and metabolism.

The human thyrotropin receptor activates G-proteins Gs and Gq/11.

G. Schultz, A. Allgeier, J. Dumont, 1994, The Journal of biological chemistry.

Dual activation by thyrotropin of the phospholipase C and cyclic AMP cascades in human thyroid

J. Mockel, E. Laurent, J. Dumont, 1987, Molecular and Cellular Endocrinology.

Differentiation expression during proliferative activity induced through different pathways: in situ hybridization study of thyroglobulin gene expression in thyroid epithelial cells

J. Dumont, P. Roger, D. Christophe, 1990, The Journal of cell biology.

Differentiated carcinomas develop as a consequence of the thyroid specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene.

M. Parmentier, C. Ledent, J. Dumont, 1995, Oncogene.

Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas.

A. Allgeier, J. Parma, J. Dumont, 2001, European journal of endocrinology.

Analysis of sequence and structure homologies between thyroglobulin and acetylcholinesterase: possible functional and clinical significance.

S. Swillens, J. Dumont, G. Vassart, 1986, Biochemical and biophysical research communications.

Effect of thyrotropin-releasing hormone on dog thyroid in vitro.

D. Delbeke, J. Dumont, J. van Sande, 1983, Biochimica et biophysica acta.

Transducing systems in the control of human thyroid cell function, proliferation and differentiation.

M. Parmentier, E. Laurent, J. Dumont, 1989, Advances in experimental medicine and biology.

Two autonomous nodules of a patient with multinodular goiter harbor different activating mutations of the thyrotropin receptor gene.

J. Parma, J. Hermans, J. Dumont, 1997, The Journal of clinical endocrinology and metabolism.

Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter☆

J. Dumont, F. Miot, C. Massart, 2013, FEBS open bio.

Gene expression and the biological phenotype of papillary thyroid carcinomas

V. Detours, J. Dumont, B. Franc, 2007, Oncogene.

Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.

S. Swillens, J. Parma, M. Tonacchera, 1995, Molecular endocrinology.