Alfred Singer

Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

A. Singer, Y. Takahama, D. Wiest, 1993, Journal of immunology.

Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.

K. M. Abraham, R. Perlmutter, A. Singer, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck.

K. M. Abraham, R. Perlmutter, A. Singer, 1992, The EMBO journal.

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

A. Singer, B. Osborne, Y. Takahama, 1994, The Journal of experimental medicine.

CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus

X. Tai, Mohamed Elsherif Badr, Zhongmei Zhang, 2023, Science.

Post-transcriptional regulation of early T cell development by T cell receptor signals.

A. Singer, Y. Takahama, Yousuke Takahama, 1992, Science.

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals.

K. S. Dash, A. Singer, J. Punt, 1997, Immunity.

Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.

C. June, A. Singer, L. Samelson, 1991, Proceedings of the National Academy of Sciences of the United States of America.

In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.

A. Singer, A. Rosenberg, M. Rees, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

A. Singer, Y. Takahama, A. Kosugi, 1991, Journal of immunology.