Susan M Jenkins

发表

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.

Stephen R. Johnson, N. Meanwell, D. Langley, 2020, Bioorganic & medicinal chemistry letters.

Diagnosing Biopharmaceutical Limitations

S. Jenkins, D. Parker, Susan M Jenkins, 2015 .

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.

Jennifer A. Natoli, Astrid A. Ortiz, S. O'connor, 2007, Bioorganic & medicinal chemistry letters.

Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.

Jennifer A. Natoli, Astrid A. Ortiz, B. Podlogar, 2007, Bioorganic & medicinal chemistry letters.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

N. Meanwell, D. Langley, Zeyu Lin, 2019, Bioorganic & medicinal chemistry letters.

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.

Barry L. Johnson, K. Kish, N. Meanwell, 2019, Journal of medicinal chemistry.

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2019, Journal of medicinal chemistry.

Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.

V. Arora, J. Knipe, F. Mcphee, 2014, Journal of pharmaceutical sciences.

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2022, Journal of medicinal chemistry.

(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.

Murugaiah A. M. Subbaiah, S. Mandlekar, N. Meanwell, 2020, European journal of medicinal chemistry.

Studies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of Gemfibrozil

A. D. Rodrigues, Stephen R. Johnson, J. Leet, 2011, Drug Metabolism and Disposition.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Functionalized triazines as potent HCV entry inhibitors.

N. Meanwell, R. Rajamani, M. Kramer, 2017, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 2020, Bioorganic & medicinal chemistry letters.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.

A. Mathur, N. Meanwell, Zeyu Lin, 2020, Bioorganic & medicinal chemistry.