Minna Nyström

发表

Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.

M. Nyström, M. Niku, M. Mutanen, 2017, The Journal of nutritional biochemistry.

Agenesis of the corpus callosum and gray matter heterotopia in three patients with constitutional mismatch repair deficiency syndrome

S. Robertson, K. Wimmer, M. Nyström, 2012, European Journal of Human Genetics.

Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1.

A. de la Chapelle, C. Sutter, P. Peltomäki, 2005, Gastroenterology.

Assessment of the InSiGHT Interpretation Criteria for the Clinical Classification of 24 MLH1 and MSH2 Gene Variants

Margherita Berardi, A. Spurdle, M. Genuardi, 2017, Human mutation.

Assessing How Reduced Expression Levels of the Mismatch Repair Genes MLH1, MSH2, and MSH6 Affect Repair Efficiency

M. Nyström, M. Kansikas, J. Kantelinen, 2014, Human mutation.

MARJAANA PUSSILA CANCER-PRECEDING GENE EXPRESSION CHANGES IN MOUSE COLON MUCOSA DIVISION OF GENETICS, DEPARTMENT OF BIOSCIENCES FACULTY OF BIOLOGICAL AND ENVIRONMENTAL SCIENCES INTEGRATIVE LIFE SCIENCE DOCTORAL PROGRAM UNIVERSITY OF HELSINKI

S. Virtanen, M. Nyström, M. Pöyhönen, 2019 .

Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6

H. Pospiech, F. Grosse, M. Nyström, 2016, FEBS letters.

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients

L. Holm, M. Nyström, M. Kansikas, 2012, Human mutation.

Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients

T. Ørntoft, C. Andersen, I. Bernstein, 2009, Familial Cancer.

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification

M. Greenblatt, S. Ollila, M. Nyström, 2008, International journal of cancer.

DNA Alterations in Lynch Syndrome

M. Nyström, M. Kansikas, Minttu Kansikas, 2013, Springer Netherlands.

Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity

P. Peltomäki, J. Mecklin, H. Järvinen, 2023, Cancer research communications.

Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh1 +/- Mice

N. Reyhani, P. Peltomäki, S. Ollila, 2013, PloS one.

Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh 1 ( + /-) Mice Pussila , Marjaana 2013-1008

N. Reyhani, P. Peltomäki, S. Ollila, 2022 .

MutSβ exceeds MutSα in dinucleotide loop repair

S. Ollila, M. Nyström, M. Kansikas, 2010, British Journal of Cancer.

Functional Analyses Help to Assess the Pathogenicity of MMR Gene Variants of Uncertain Significance

M. Nyström, M. Kansikas, Minttu Kansikas, 2013 .

Mechanisms of pathogenicity in human MSH2 missense mutants

J. Jiricny, S. Ollila, M. Nyström, 2008, Human mutation.

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.

A. de la Chapelle, P. Peltomäki, M. Greenblatt, 2006, Gastroenterology.

Lynch syndrome genetics and clinical implications.

P. Peltomäki, J. Mecklin, M. Nyström, 2023, Gastroenterology.

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

S. Knuutila, A. Ristimäki, P. Peltomäki, 2018, EBioMedicine.

Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer

L. Holm, J. Kere, P. Törönen, 2018, Carcinogenesis.

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

A. Ristimäki, P. Peltomäki, J. Mecklin, 2015, Clinical Epigenetics.

Human Mutation

M. Nyström, M. Kansikas, Mariann Kasela, 2019 .

Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome

S. Ollila, M. Nyström, R. Cusano, 2009, Familial Cancer.

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR)

Andrew J. Grimm, J. Bond, M. Greenblatt, 2007, Human mutation.

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

P. Törönen, P. Peltomäki, J. Mecklin, 2024, EBioMedicine.

Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome.

M. Lalowski, N. Reyhani, M. Baumann, 2014, The Journal of nutritional biochemistry.

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

S. Ollila, M. Nyström, A. Gerdes, 2011, Familial Cancer.

The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC.

P. Peltomäki, H. Lynch, T. Raevaara, 2006, International journal of oncology.

Abstract 4766: DNA methylation changes in Lynch syndrome associated colorectal adenomas and carcinomas

A. Ristimäki, P. Peltomäki, J. Mecklin, 2015 .

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon.

M. Baumann, R. Soliymani, S. Valo, 2017, Cancer research.

Functional characterization of MLH1 missense variants identified in lynch syndrome patients

N. de Wind, L. Rasmussen, I. Bernstein, 2012, Human mutation.

Verification of the Three-Step Model in Assessing the Pathogenicity of Mismatch Repair Gene Variants

M. Nyström, M. Kansikas, R. Kariola, 2010, Human mutation.