Igor Dolgalev

发表

TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma.

A. Tsirigos, I. Dolgalev, S. Meehan, 2017, Cell stem cell.

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.

M. Meyerson, Guangwu Guo, A. Heguy, 2015, Cancer research.

Integrative genomic profiling of human prostate cancer.

C. Sander, H. Hieronymus, W. Gerald, 2010, Cancer cell.

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

N. Socci, A. Viale, A. Ferrando, 2012, The New England journal of medicine.

The Mutational Landscape of Adenoid Cystic Carcinoma

Benjamin J. Raphael, Simion I. Chiosea, Benjamin E. Gross, 2013, Nature Genetics.

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity

I. Dolgalev, Anastasia N. Tikhonova, Igor Dolgalev, 2021, Frontiers in Cell and Developmental Biology.

Mutations in GNA11 in uveal melanoma.

J. O'Brien, R. Khanin, A. Heguy, 2010, The New England journal of medicine.

Modulating mitofusins to control mitochondrial function and signaling

B. Agianian, A. Tsirigos, I. Dolgalev, 2022, Nature Communications.

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

D. Levine, B. Neel, I. Dolgalev, 2019, Nature Communications.

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

C. Perou, C. Rudin, G. Freeman, 2021, Nature Cancer.

Drug-induced adaptation along a resistance continuum in cancer cells

Gustavo S. França, D. Levine, Gal Avital, 2022, bioRxiv.

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

M. Washburn, L. Florens, A. Tsirigos, 2019, Nature Immunology.

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis

D. Bar-Sagi, I. Dolgalev, M. Ljungman, 2019, Genes & development.

The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis

A. Tsirigos, I. Dolgalev, I. Osman, 2022, Science advances.

Oncogenes overexpressed in metastatic oral cancers from patients with pain: potential pain mediators released in exosomes

N. H. Tu, D. Albertson, B. Schmidt, 2020, Scientific Reports.

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems

A. Heguy, J. Carucci, I. Dolgalev, 2023, Science Immunology.

Rare variants in the neurotrophin signaling pathway implicated in schizophrenia risk

Adriana Heguy, Daniel Antonius, Igor Dolgalev, 2015, Schizophrenia Research.

The bone marrow microenvironment at single-cell resolution

R. Satija, A. Heguy, A. Tsirigos, 2019, Nature.

The integrated landscape of driver genomic alterations in glioblastoma

Raul Rabadan, Peter Canoll, Jeffrey N. Bruce, 2013, Nature Genetics.

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.

Cheng Cheng, Aristotelis Tsirigos, Iannis Aifantis, 2020, Cancer cell.

ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

I. Dolgalev, A. Bhardwaj, C. Lyssiotis, 2021, Genes & development.

Mutations in GNA 11 in Uveal Melanoma

Sozen, J. O'Brien, R. Khanin, 2022 .

Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα.

D. Zheng, I. Dolgalev, Masato Tanaka, 2021, Blood advances.

An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma

M. Esteller, A. Tsirigos, I. Dolgalev, 2023, Nature Communications.

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Nicolas Stransky, A. Heguy, H. Pass, 2022, bioRxiv.

Microglandular adenosis is an advanced precursor breast lesion with evidence of molecular progression to matrix-producing metaplastic carcinoma.

A. Heguy, I. Dolgalev, I. Osman, 2019, Human pathology.

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

O. Abdel-Wahab, R. Dickins, B. Neel, 2017, Cell.

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

B. Strahl, A. Tsirigos, I. Dolgalev, 2016, Nature Cell Biology.

Siah2 control of T-regulatory cells limits anti-tumor immunity

K. Brown, J. Marine, F. Rambow, 2020, Nature Communications.

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

Thomas V. Karathanos, Francisco J. Alvarado, N. Trayanova, 2017, Nature Communications.

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

Francisco J. Sánchez-Rivera, C. Rudin, T. Jacks, 2017, Nature Medicine.

Variability in small airway epithelial gene expression among normal smokers.

R. Crystal, I. Dolgalev, N. Hackett, 2008, Chest.

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

Neville E. Sanjana, B. Neel, I. Dolgalev, 2023, The Journal of experimental medicine.

Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

Neville E. Sanjana, B. Neel, I. Dolgalev, 2022, bioRxiv.

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.

D. Gilliland, B. Ebert, M. L. Beau, 2009, Blood.

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Aristotelis Tsirigos, Iannis Aifantis, Ming-Ming Zhou, 2014, Cell reports.

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis.

Raymond H. W. Lam, M. Snuderl, D. Zagzag, 2018, Biomaterials.

Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

X. Castells, A. Heguy, J. Zavadil, 2015, Cancer Epidemiology, Biomarkers & Prevention.

Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research

C. Marsit, K. Overvad, E. Weiderpass, 2015, Cancer Epidemiology, Biomarkers & Prevention.

MSigDB Gene Sets for Multiple Organisms in a Tidy Data Format [R package msigdbr version 7.4.1]

Igor Dolgalev, I. Dolgalev, Igor Dolgalev, 2021 .

Huntington’s Disease Protein Huntingtin Associates with its own mRNA

A. Heguy, I. Dolgalev, N. Tanese, 2016, Journal of Huntington's disease.

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

R. Weinberg, B. Neel, F. Dao, 2020, bioRxiv.

Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma

D. Levine, B. Neel, I. Dolgalev, 2018, bioRxiv.

Targeted mutational profiling of peripheral T-cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis

N. Socci, A. Viale, J. Teruya-Feldstein, 2014, Leukemia.

A Population of Tumor-Infiltrating CD4+ T-cells Co-expressing CD38 and CD39 is Associated with Checkpoint Inhibitor Resistance.

David M. Woods, J. Weber, A. Puranik, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.

Case Start Timing of Adult Spinal Deformity Surgeries: Does the Wait Matter?

I. Dolgalev, P. Passias, T. Errico, 2022, International Journal of Spine Surgery.

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

A. Heguy, C. Hajdu, A. Tsirigos, 2022, bioRxiv.

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

David T. W. Jones, David C. Jones, V. Hovestadt, 2018, Nature Communications.

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

G. Freeman, P. Hammerman, A. Bass, 2018, Cancer Immunology Research.

MicroRNA‐125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway

K. Flaherty, H. Tawbi, E. Bernstein, 2017, Pigment cell & melanoma research.

MB-17NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA

David T. W. Jones, V. Hovestadt, S. Pfister, 2015 .

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

A. Tsirigos, I. Dolgalev, Patrice Nancy, 2017, The Journal of clinical investigation.

SPOP mutations in prostate cancer across demographically diverse patient cohorts.

H. Hieronymus, M. Rubin, A. Tewari, 2014, Neoplasia.

Complications After Adult Spinal Deformity Surgeries: All Are Not Created Equal

I. Dolgalev, P. Passias, T. Errico, 2021, International Journal of Spine Surgery.

Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

A. Heguy, C. Hajdu, A. Tsirigos, 2023, Nature communications.

Targeting the Atf7ip–Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity

D. Schadendorf, B. Ueberheide, Ting Chen, 2021, Cancer Immunology Research.

Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF

B. Taylor, A. Viale, E. Stanchina, 2012, Oncogene.

Complete Genome Sequence of Kluyvera intestini sp. nov., Isolated from the Stomach of a Patient with Gastric Cancer

A. Heguy, A. Tsirigos, I. Dolgalev, 2017, Genome Announcements.

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.

B. Taylor, P. Stephens, J. Baselga, 2016, Cancer discovery.

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

A. Heguy, J. Golfinos, M. Snuderl, 2017, Oncotarget.

Responses of the human airway epithelium transcriptome to in vivo injury.

A. Heguy, R. Crystal, I. Dolgalev, 2007, Physiological genomics.

Pseudarthrosis and Rod Fracture Rates after Transforaminal Lumbar Interbody Fusion at the Caudal Levels of Long Constructs for Adult Spinal Deformity Surgery.

I. Dolgalev, T. Errico, T. Raman, 2021, World neurosurgery.

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

A. Heguy, I. Dolgalev, S. Ginsberg, 2015, PloS one.

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

Kwok-Kin Wong, B. Neel, A. Koide, 2020, The Journal of experimental medicine.

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth

A. Heguy, J. Golfinos, M. Snuderl, 2016, Oncogenesis.

The Aquila Digital Community The Aquila Digital Community High Male Sexual Investment As a Driver of Extinction in Fossil High Male Sexual Investment As a Driver of Extinction in Fossil Ostracods Ostracods

A. Heguy, A. Tsirigos, P. Frenette, 2022 .

The impact of inflammation-induced tumor plasticity during myeloid transformation.

J. Byrd, O. Abdel-Wahab, A. Tsirigos, 2022, Cancer discovery.

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

David M. Woods, I. Dolgalev, A. Laino, 2019, Journal of Immunotherapy for Cancer.

H 3 K 27 me 3 dynamics dictate evolving uterine states in pregnancy and parturition

A. Tsirigos, I. Dolgalev, Patrice Nancy, 2022 .

The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity.

A. Tsirigos, G. Jour, N. Kourtis, 2024, Nature cell biology.

MIT Open Access

Francisco J. Sánchez-Rivera, A. Bhutkar, J. Poirier, 2022 .

Cellular adaptation to cancer therapy along a resistance continuum.

Gal Avital, Maayan Baron, A. Marusyk, 2024, Nature.

A pan-cancer organoid platform for precision medicine.

Brian M. Larsen, Aly A. Khan, K. White, 2021, Cell reports.

Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche

Iannis Aifantis, Jie Tong, Igor Dolgalev, 2020, Science Advances.

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

R. Shiekhattar, R. Verdun, B. Neel, 2023, Cell reports.

Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP 1 , NF 2 , CDKN 2 A , and CUL 1 in Malignant Pleural Mesothelioma

M. Meyerson, Guangwu Guo, A. Heguy, 2014 .