Magdalena M. Szewczyk

发表

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

R. Aebersold, C. Arrowsmith, M. Vedadi, 2022, Biochimica et biophysica acta. Gene regulatory mechanisms.

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

Clara D. Christ, C. Arrowsmith, H. Weinmann, 2016, Journal of medicinal chemistry.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Jayme L. Dahlin, J. Baell, M. Walters, 2017, Nature Communications.

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Phage display: concept, innovations, applications and future.

Jyoti Pande, J. Pande, M. Szewczyk, 2010, Biotechnology advances.

Aortic smooth muscle and endothelial plasma membrane Ca2+ pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1.

J. Pande, M. Szewczyk, A. Grover, 2006, American journal of physiology. Cell physiology.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

B. Haibe-Kains, K. Massirer, D. Cescon, 2022, Nature Chemical Biology.

Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer

Benjamin Haibe-Kains, D. Cescon, M. Lupien, 2021 .

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

B. Kuster, S. Knapp, C. Sotriffer, 2021, bioRxiv.

Ca2+-pumps and Na+–Ca2+-exchangers in coronary artery endothelium versus smooth muscle

M. Szewczyk, A. Grover, P. Rangachari, 2007, Journal of cellular and molecular medicine.

Ca2+‐mediated ascorbate release from coronary artery endothelial cells

M. Szewczyk, A. Grover, C. Kwan, 2006, British journal of pharmacology.

A chemical probe to modulate human GID4 Pro/N-degron interactions

S. Knapp, J. Min, C. Arrowsmith, 2023, bioRxiv.

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

Laura E. Herring, J. Licht, C. Arrowsmith, 2023, Journal of the American Chemical Society.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Anthony D. Keefe, Christopher J. Mulhern, A. Keefe, 2023, Journal of medicinal chemistry.

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, Nature Chemical Biology.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, bioRxiv.

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Bas J. Wouters, M. Minden, O. Abdel-Wahab, 2019, Cancer cell.

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Kyle V. Butler, C. Arrowsmith, M. Schapira, 2016, ACS chemical biology.

extracellular inhibitor caloxin 1b1 pump isoforms are inhibited differently by the 2+ Casmooth muscle and endothelial plasma membrane

J. Pande, M. Szewczyk, A. Grover, 2016 .

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, bioRxiv.

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations

M. Minden, D. Barsyte-Lovejoy, Fengling Li, 2023, bioRxiv.

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Xi-Ping Huang, B. Roth, P. Atadja, 2015, Angewandte Chemie.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2016, Journal of medicinal chemistry.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Julian E. Fuchs, O. Fedorov, C. Arrowsmith, 2019, Nature Chemical Biology.

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

K. Saikatendu, C. Arrowsmith, M. Schapira, 2018, Oncotarget.

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

J. Dick, M. Minden, M. Lupien, 2019, Experimental hematology.

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. Minden, M. Lupien, C. Arrowsmith, 2022, bioRxiv.

Chemical Biology Approaches for Characterization of Epigenetic Regulators.

C. Arrowsmith, P. Prinos, M. Szewczyk, 2016, Methods in enzymology.

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

A. Fox-Robichaud, M. Szewczyk, B. Trigatti, 2018, The Journal of Biological Chemistry.

Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca2+-pump isoform 4, on coronary artery

J. Pande, M. Szewczyk, A. Grover, 2008, Journal of cellular and molecular medicine.

Caloxins: a novel class of selective plasma membrane Ca2+ pump inhibitors obtained using biotechnology

J. Pande, M. Szewczyk, A. Grover, 2008, Pflügers Archiv - European Journal of Physiology.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, bioRxiv.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

Anne E Carpenter, Jayme L. Dahlin, Bruce K. Hua, 2022, bioRxiv.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Amber L. Couzens, M. Tyers, A. Gingras, 2020, Nature Communications.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses

Amber L. Couzens, M. Tyers, A. Gingras, 2018, bioRxiv.

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2015, ACS medicinal chemistry letters.

A First-in-class, Highly Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

R. Campbell, C. Arrowsmith, M. Schapira, 2020, bioRxiv.

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Cheryl H Arrowsmith, Peter J Brown, Mary M Mader, 2018, ACS medicinal chemistry letters.

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

C. Arrowsmith, M. Schapira, M. Szewczyk, 2023, bioRxiv.

Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid

Simon S. Woo, M. Vedadi, S. LaPlante, 2021, ChemMedChem.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2020, bioRxiv.

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

A resource to enable chemical biology and drug discovery of WDR Proteins

Anthony D. Keefe, Christopher J. Mulhern, S. Kearnes, 2024, bioRxiv.

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, Communications Biology.