Minying Cai

发表

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Philipp M. Cromm, A. Plowright, D. Craik, 2018, Journal of medicinal chemistry.

Novel approaches to the design of bioavailable melanotropins

M. Cai, Yang Zhou, Minying Cai, 2017, Expert opinion on drug discovery.

Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.

V. Hruby, H. Kessler, M. Cai, 2015, Journal of medicinal chemistry.

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies.

V. Hruby, H. Kessler, M. Cai, 2010, Journal of the American Chemical Society.

Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.

E. Novellino, P. Grieco, V. Hruby, 2008, Journal of medicinal chemistry.

Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver

B. Ghimire, M. Cai, E. Savontaus, 2022, bioRxiv.

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages

T. Lehtimäki, V. Hruby, C. Weber, 2017, Circulation.

Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

Paolo Grieco, Antonio Lavecchia, P. Grieco, 2002, Journal of medicinal chemistry.

Characterization of TCP-1 probes for molecular imaging of colon cancer.

A. Rouse, A. Gmitro, B. Banerjee, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice.

V. Hruby, M. Cai, Katja Kaipio, 2020, European journal of pharmacology.

Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling

V. Hruby, Hongchang Qu, D. McPherson, 2009, Regulatory Peptides.

Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

V. Hruby, M. Cai, S. Wardlaw, 2008, Peptides.

Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells.

Z. Salamon, G. Tollin, E. Navratilova, 2009, Analytical biochemistry.

New paradigms and tools in drug design for pain and addiction

I. Alves, Z. Salamon, G. Tollin, 2006, The AAPS Journal.

Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge.

James P. Cain, V. Hruby, M. Cai, 2011, European journal of pharmacology.

Cell Signaling and Trafficking of Human Melanocortin Receptors in Real Time Using Two‐photon Fluorescence and Confocal Laser Microscopy: Differentiation of Agonists and Antagonists

M. Staňková, V. Hruby, M. Cai, 2006, Chemical biology & drug design.

Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.

V. Hruby, M. Cai, Saghar Mowlazadeh Haghighi, 2020, ACS pharmacology & translational science.

α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes

B. Ghimire, M. Cai, E. Savontaus, 2023, bioRxiv.

Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation.

V. Hruby, M. Cai, Saghar Mowlazadeh Haghighi, 2017, Journal of medicinal chemistry.

CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.

V. Hruby, A. Mollica, M. Cai, 2022, Journal of medicinal chemistry.

An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.

M. Staňková, V. Hruby, M. Cai, 2013, Biochemistry.

Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma.

V. Hruby, Zhonglin Liu, Hongchang Qu, 2011, European journal of pharmacology.

Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors

James P. Cain, V. Hruby, J. Vagner, 2010, Peptides.

Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.

James P. Cain, V. Hruby, M. Cai, 2008, Journal of medicinal chemistry.

Effects of Macrocycle Size and Rigidity on Melanocortin Receptor‐1 and ‐5 Selectivity in Cyclic Lactam α‐Melanocyte‐Stimulating Hormone Analogs

V. Hruby, So-Yeop Han, M. Cai, 2006, Chemical biology & drug design.

Structure–activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position

P. Grieco, V. Hruby, M. Cai, 2006, Peptides.

An Unusual Conformation of MSH Analogues Leads to a Selective Human Melanocortin 1 Receptor Antagonist for Targeting Melanoma Cells

M. Staňková, V. Hruby, M. Cai, 2013 .

Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.

E. Novellino, P. Grieco, V. Hruby, 2015, Journal of medicinal chemistry.

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

V. Hruby, M. Cai, Yang Zhou, 2019, Molecules.

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.

V. Hruby, H. Kessler, M. Cai, 2017, Biochemistry.

Novel binding motif of ACTH analogues at the melanocortin receptors.

V. Hruby, C. Crasto, M. Cai, 2009, Biochemistry.

Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.

P. Grieco, V. Hruby, M. Cai, 2009, Journal of medicinal chemistry.

Contribution of the Conserved Amino Acids of the Melanocortin-4 Receptor in d-[Nle4,Phe7]-α-Melanocyte-stimulating Hormone Binding and Signaling*

V. Hruby, M. Cai, K. Georgeson, 2007, Journal of Biological Chemistry.

Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

James P. Cain, V. Hruby, M. Cai, 2007, Current topics in medicinal chemistry.

Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.

V. Hruby, M. Cai, D. McPherson, 2009, Biochemical pharmacology.

The Development of a Novel Highly Selective and Potent Agonist for Human Melanocortin 4 Receptor

V. Hruby, M. Kavarana, D. Trivedi, 2001 .

Development of novel frog‐skin peptide scaffolds with selectivity towards melanocortin receptor subtypes

D. Craik, V. Hruby, Q. Kaas, 2020 .

Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation.

V. Hruby, M. Cai, J. Dai, 2018, European journal of medicinal chemistry.

Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R.

V. Hruby, M. Cai, Saghar Mowlazadeh Haghighi, 2023, Journal of medicinal chemistry.

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

M. Staňková, Jinfa Ying, V. Hruby, 2005, Peptides.

Novel 3D Pharmacophore of α-MSH/γ-MSH Hybrids Leads to Selective Human MC1R and MC3R Analogues†

M. Staňková, V. Hruby, M. Cai, 2005 .

Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy.

M. Staňková, V. Hruby, M. Cai, 2004, Journal of the American Chemical Society.

Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.

C. Xiong, V. Hruby, M. Cai, 2004, The journal of peptide research : official journal of the American Peptide Society.

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

James P. Cain, V. Hruby, M. Cai, 2008, Biopolymers.

Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles.

V. Hruby, Minying Cai, 2013, Annual review of pharmacology and toxicology.