Estíbaliz Miranda

发表

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

F. Prósper, M. Cascante, P. de Atauri, 2017, Scientific Reports.

Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma

C. Mason, F. Prósper, J. Martín-Subero, 2021, Leukemia.

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

F. Prósper, J. Martín-Subero, M. Calasanz, 2019, Haematologica.

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.

J. Martinez-Climent, F. Prósper, X. Agirre, 2018, Journal of medicinal chemistry.

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism

Iñigo Apaolaza, Luis Tobalina, Xabier Agirre, 2017, Nature Communications.

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

E. Campo, P. Flicek, F. Prósper, 2019, bioRxiv.

Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia

J. Cigudosa, F. Prósper, J. Martín-Subero, 2011, PloS one.

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene epigenetically regulated

J. Martín-Subero, M. Calasanz, X. Agirre, 2019 .

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome

F. Prósper, X. Agirre, O. Rabal, 2017, PloS one.

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

F. Prósper, G. De Velasco, X. Agirre, 2019, Nature Medicine.

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

J. Martinez-Climent, F. Prósper, J. Martín-Subero, 2017, Nature Communications.

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

J. Martín-Subero, M. Calasanz, X. Agirre, 2024, Nature communications.

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.

F. Prósper, X. Agirre, J. Oyarzábal, 2021, Journal of medicinal chemistry.

Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces.

J. Martinez-Climent, F. Prósper, X. Agirre, 2018, Journal of medicinal chemistry.

Identifying Lethal Dependencies with HUGE Predictive Power

F. Prósper, X. Agirre, Á. Rubio, 2021, bioRxiv.

Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts

F. Prósper, J. Martín-Subero, J. Miguel, 2021, American journal of hematology.