David Santamaría

发表

Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6

Pierre Dubus, M. Barbacid, M. Malumbres, 2004, Cell.

Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer.

D. Santamaría, E. Nadal, C. Ambrogio, 2020, Trends in cancer.

Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

D. Santamaría, S. Ortega, David Santamaría, 2006, Frontiers in bioscience : a journal and virtual library.

Cdk6‐Dependent Regulation of G1 Length Controls Adult Neurogenesis

L. Nguyen, G. Moonen, M. Barbacid, 2011, Stem cells.

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.

M. Barbacid, P. Dubus, D. Santamaría, 2011, Cancer cell.

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

M. Malumbres, D. Santamaría, G. de Cárcer, 2020, Cell Death & Differentiation.

Overall Cdk activity modulates the DNA damage response in mammalian cells

M. Barbacid, D. Santamaría, Antonio Cerqueira, 2009, The Journal of cell biology.

Cdk7

D. Santamaría, Miguel Ganuza, David Santamaría, 2012, Cell cycle.

An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia

D. Santamaría, P. Dubreuil, T. Prebet, 2016, Oncotarget.

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

Haiyun Wang, John C. Hunter, Shuai Li, 2018, Cell.

RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression.

M. Barbacid, C. Guerra, D. Santamaría, 2021, Cancer cell.

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

M. Barbacid, C. Guerra, D. Santamaría, 2020, Proceedings of the National Academy of Sciences.

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

M. Barbacid, Marta Puyol, Alberto Martin, 2010, Cancer cell.

Functional reprogramming of polyploidization in megakaryocytes.

M. Barbacid, M. Malumbres, D. Santamaría, 2015, Developmental Cell.

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

M. Barbacid, D. Santamaría, P. Sicinski, 2018, Scientific Reports.

Cdk1 is sufficient to drive the mammalian cell cycle

Pierre Dubus, M. Barbacid, M. Malumbres, 2007, Nature.

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

M. Barbacid, D. Pisano, M. Blasco, 2012, The EMBO journal.

Functional reprogramming of polyploidization in megakaryocytes.

M. Barbacid, S. Ortega, M. Trakala, 2015, Developmental cell.

Mice thrive without Cdk4 and Cdk2

M. Barbacid, M. Malumbres, Alberto Martin, 2007, Molecular oncology.

A Braf kinase-inactive mutant induces lung adenocarcinoma

M. Barbacid, D. Pisano, N. Rosen, 2017, Nature.

Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer

X. Solé, D. Santamaría, A. Villanueva, 2021, Cancers.

How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC).

D. Santamaría, S. Novello, D. Planchard, 2021, Cancer treatment reviews.

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy

M. Barbacid, D. Santamaría, G. Gómez-López, 2016, ESMO Open.

CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase

D. Santamaría, S. Ortega, R. Benavente, 2015, Journal of Cell Science.

In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma

M. Barbacid, D. Santamaría, C. Ambrogio, 2017, Oncogene.

Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts.

M. Esteller, M. Barbacid, F. Mulero, 2014, Cancer research.

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

M. Barbacid, M. Hidalgo, M. Serrano, 2016, Nature Medicine.

Toll-like Receptor-4 (TLR4) Down-regulates MicroRNA-107, Increasing Macrophage Adhesion via Cyclin-dependent Kinase 6*

M. Barbacid, D. Santamaría, L. O’Neill, 2011, The Journal of Biological Chemistry.

Integrated Systems and Technologies ModelingLungCancerEvolutionandPreclinicalResponseby Orthotopic Mouse Allografts

M. Esteller, M. Barbacid, F. Mulero, 2014 .

Lentiviral-based approach for the validation of cancer therapeutic targets in vivo.

M. Barbacid, D. Santamaría, C. Scuoppo, 2014, BioTechniques.

A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance

Sam W. Lee, D. Santamaría, É. Darbo, 2018, Cell adhesion & migration.

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1

J. Pines, D. Santamaría, Lorena Clay-Farrace, 2003, The EMBO journal.

Genetic Characterization of the Role of the Cip/Kip Family of Proteins as Cyclin-Dependent Kinase Inhibitors and Assembly Factors

M. Barbacid, Alberto Martin, P. Dubus, 2014, Molecular and Cellular Biology.