Christoph J Blohmke

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Innate immunity and inflammation in cystic fibrosis lung disease

C. Blohmke, Christoph J Blohmke, 2011 .

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi

C. Fraser, L. Magder, Arthur Brady, 2018, mBio.

Typhoid epidemiology, diagnostics and the human challenge model

A. Pollard, T. Darton, C. Blohmke, 2014, Current opinion in gastroenterology.

Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever

James C. Wright, O. Ramilo, A. Mejias, 2016, The Journal of experimental medicine.

Computational modeling of microfluidic data provides high-throughput affinity estimates for monoclonal antibodies

D. Medini, O. Finco, P. Lo Surdo, 2021, Computational and structural biotechnology journal.

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

L. Magder, M. Levine, A. Pollard, 2017, Front. Immunol..

Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses

C. Fjell, R. Hancock, J. Hogg, 2012, The Journal of Immunology.

The Pseudomonas aeruginosa Autoinducer 3O-C12 Homoserine Lactone Provokes Hyperinflammatory Responses from Cystic Fibrosis Airway Epithelial Cells

Robert E. W. Hancock, Matthew L. Mayer, R. Hancock, 2011, PloS one.

Contributes to p 38 MAPK-Mediated Innate Response in Cystic Fibrosis Airway Cells Atypical Activation of the Unfolded Protein

C. Fjell, R. Hancock, J. Hogg, 2012 .

Immune Responses Contributes to p38 MAPK-Mediated Innate Response in Cystic Fibrosis Airway Cells Atypical Activation of the Unfolded Protein

C. Fjell, R. Hancock, J. Hogg, 2012 .

Molecular correlates of vaccine-induced protection against typhoid fever

D. Kelly, J. Trück, A. Pollard, 2023, The Journal of clinical investigation.

Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

L. Magder, G. Dougan, M. Levine, 2015, PLoS pathogens.

Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

Ly-Mee Yu, A. Pollard, B. Angus, 2017, The Lancet.

The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles

D. Altmann, R. Boyton, A. Pollard, 2014, Immunology.

TLR5 as an Anti-Inflammatory Target and Modifier Gene in Cystic Fibrosis

M. Corey, J. Zieleński, R. Dorfman, 2010, The Journal of Immunology.

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

L. Magder, M. Levine, A. Pollard, 2016, Journal of Translational Medicine.

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever

G. Dougan, H. Nakaya, A. Pollard, 2017, Front. Immunol..

Transcriptomics in Human Challenge Models

A. Pollard, Jennifer Hill, C. Blohmke, 2017, Front. Immunol..

Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases

G. Dougan, S. Baker, A. Pollard, 2019, EMBO molecular medicine.

Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum*

Xu Shen, Rolf Hilgenfeld, Hualiang Jiang, 2006, Journal of Biological Chemistry.

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

Robert E. W. Hancock, Matthew L. Mayer, Reza Falsafi, 2013, The Journal of Immunology.

from Cystic Fibrosis Cells Attenuates Hyperinflammatory Responses Rescue of Dysfunctional Autophagy

C. Fjell, R. Hancock, S. Turvey, 2012 .

Vi-Vaccinations Induce Heterogeneous Plasma Cell Responses That Associate With Protection From Typhoid Fever

G. Obermoser, H. Maecker, A. Pollard, 2020, Frontiers in Immunology.

Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

S. Baker, A. Pollard, Ushma Galal, 2018, Front. Immunol..

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

E. Giannoulatou, A. Pollard, C. Webster, 2015, PLoS neglected tropical diseases.

Systems analysis of human responses to an aluminium hydroxide-adsorbed TLR7 agonist (AS37) adjuvanted vaccine reveals a dose-dependent and specific activation of the interferon-mediated antiviral response.

S. Bertholet, D. Medini, O. Finco, 2022, Vaccine.

Early transcriptional responses to human enteric fever challenge

A. Pollard, H. Dobinson, T. Darton, 2023, Infection and immunity.

Design, recruitment, and microbiological considerations in human challenge studies.

F. Hayden, M. Levine, D. Altmann, 2015, The Lancet. Infectious diseases.

Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model

L. Magder, M. Levine, A. Pollard, 2017, Front. Immunol..

Dissecting in Vitro the Activation of Human Immune Response Induced by Shigella sonnei GMMA

C. Ulivieri, E. Bartolini, M. Brazzoli, 2022, Frontiers in Cellular and Infection Microbiology.

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers

A. Pollard, Liye Chen, E. Jones, 2021, bioRxiv.

Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model

G. Dougan, G. Obermoser, A. Pollard, 2019, Nature Medicine.

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

G. Dougan, M. Levine, A. Pollard, 2015, PLoS neglected tropical diseases.

Gene expression profiles are different in venous and capillary blood: Implications for vaccine studies.

D. Stein, Andrew J. Pollard, Christoph J Blohmke, 2016, Vaccine.

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

G. Dougan, S. Baker, D. Bumann, 2018, Nature Immunology.

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

G. Dougan, M. Levine, S. Lockhart, 2016, PLoS neglected tropical diseases.

An Appraisal of the Clinical Features of Pediatric Enteric Fever: Systematic Review and Meta-analysis of the Age-Stratified Disease Occurrence

A. Pollard, M. Voysey, Carl D Britto, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Early transcriptional responses to human enteric fever challenge

A. Pollard, H. Dobinson, T. Darton, 2023, Infection and Immunity.

Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever

L. Magder, M. Levine, A. Pollard, 2022, Cellular immunology.

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model

A. Simmons, A. Pollard, B. Angus, 2020, PLoS neglected tropical diseases.

Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia

S. Baker, A. Pollard, Claire Jones, 2017, The Journal of infection.

Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model

S. Baker, M. Levine, A. Pollard, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal

S. Baker, A. Pollard, M. Voysey, 2017, Front. Microbiol..