C. B. Newgard

发表

Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?

C. Newgard, J. McGarry, D. W. Foster, 1983, The Journal of biological chemistry.

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Guillaume Adelmant, Bruce M. Spiegelman, Jerry Donovan, 2001, Nature.

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

C. Newgard, T. Alam, R. Gerard, 1994, Methods in cell biology.

Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion*

C. Newgard, S. Ronnebaum, S. Burgess, 2007, Journal of Biological Chemistry.

A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2006, Journal of Biological Chemistry.

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

M. Prentki, H. Mulder, C. Newgard, 2000, Diabetes.

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

C. Newgard, Guoxun Chen, R. Unger, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

C. Newgard, R. Unger, May-yun Wang, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural Relationships in Glycogen Phosphorylases a

R. Fletterick, P. Hwang, C. Newgard, 1986, Annals of the New York Academy of Sciences.

The family of glycogen phosphorylases: structure and function.

R. Fletterick, P. Hwang, C. Newgard, 1989, Critical reviews in biochemistry and molecular biology.

GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.

J. H. Johnson, C. Newgard, T. Becker, 1994, The Journal of biological chemistry.

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.

C. Newgard, R. Unger, Y. Lee, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

C. Newgard, R. Gerard, A. Gómez-Foix, 1992, The Journal of biological chemistry.

Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.

J. H. Johnson, C. Newgard, John H. Johnson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.

C. Newgard, R. Unger, May-yun Wang, 1998, The Journal of biological chemistry.

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.

J. H. Johnson, C. Newgard, T. Becker, 1994, The Journal of biological chemistry.

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

C. Newgard, A. Saltiel, M. Brady, 2000, Diabetes.

Metabolic engineering with recombinant adenoviruses.

H. Berman, C. Newgard, R. O’Doherty, 1999, Annual review of nutrition.

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

A. Murphy, K. Lyons, G. Yancopoulos, 2009, Molecular endocrinology.

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.

J. H. Johnson, C. Newgard, R. Unger, 1995, The Journal of biological chemistry.

Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans.

C. Ucla, C. Newgard, T. Nouspikel, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic coupling factors in pancreatic beta-cell signal transduction.

C. Newgard, J. McGarry, C. Newgard, 1995, Annual review of biochemistry.

Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-Cells*

H. Mulder, C. Newgard, Danhong Lu, 2001, The Journal of Biological Chemistry.

Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion

M. Prentki, C. Newgard, J. McGarry, 1998, The Journal of Biological Chemistry.

Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.

J. H. Johnson, L. Orci, C. Newgard, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Coordinated Regulatory Variation Associated with Gestational Hyperglycemia Regulates Expression of the Novel Hexokinase HKDC1

Christopher D. Brown, Timothy E. Reddy, D. Scholtens, 2014, Nature Communications.

Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass.

C. Newgard, T. Alam, R. Unger, 1991, Molecular endocrinology.

The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14.

R. Fletterick, C. Newgard, R. Lebo, 1987, American journal of human genetics.

New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system.

A. Lange, Y. Li, A. Berteloot, 2000, European journal of biochemistry.

Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.

C. Newgard, J. McGarry, D. W. Foster, 1984, The Journal of biological chemistry.

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

C. Newgard, R. O’Doherty, D. Lehman, 1999, Diabetes.

Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.

H. Berman, C. Newgard, C. B. Newgard, 1998, Biochemistry.

Adenovirus-mediated Overexpression of Liver 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase in Gluconeogenic Rat Hepatoma Cells

C. Newgard, A. Lange, T. Becker, 1995, The Journal of Biological Chemistry.

Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.

C. Newgard, M. G. Dube, S. Kalra, 1998, The Journal of clinical investigation.

Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.

C. Newgard, K. Bornfeldt, R. O’Doherty, 1999, The American journal of physiology.