Hisham Qosa

发表

Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies.

K. E. El Sayed, A. Kaddoumi, Alaa H. Abuznait, 2013, ACS chemical neuroscience.

Pulmonary, gastrointestinal and urogenital pharmacology Orlistat limits cholesterol intestinal absorption by Niemann-pick C1- like 1 (NPC1L1) inhibition

S. Alqahtani, A. Kaddoumi, B. Primeaux, 2015 .

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

J. Keller, P. Couraud, I. Romero, 2014, Neuropharmacology.

Neuroprotective Effects of Extra‐Virgin Olive Oil and its Components in Alzheimer's Disease

A. Kaddoumi, Alaa H. Abuznait, H. Qosa, 2017 .

Effect of mouse strain as a background for Alzheimer's disease models on the clearance of amyloid-β.

A. Kaddoumi, H. Qosa, Hisham Qosa, 2016, Journal of systems and integrative neuroscience.

Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

P. Pasinelli, D. Trotti, David S. Miller, 2015, Brain Research.

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice.

H. Levine, J. Keller, B. Ibrahim, 2015, The Journal of nutritional biochemistry.

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

J. Keller, K. E. El Sayed, A. Kaddoumi, 2015, ACS chemical neuroscience.

A. Kaddoumi, H. Qosa, Loqman A. Mohamed, 2015, ACS chemical neuroscience.

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.

H. Levine, J. Keller, A. Kaddoumi, 2014, Biochimica et biophysica acta.

High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.

J. Keller, Quoc-Viet Duong, A. Kaddoumi, 2016, Journal of Alzheimer's disease : JAD.

Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease.

A. Kaddoumi, R. A. Hill, Alaa H. Abuznait, 2012, Journal of Alzheimer's disease : JAD.

Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes.

D. Volpe, A. Ribeiro, N. Hartman, 2021, Journal of pharmacological and toxicological methods.

The development of biological therapies for neurological diseases: moving on from previous failures

D. Volpe, H. Qosa, Hisham Qosa, 2018, Expert opinion on drug discovery.

In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia

Brittany R. Avaritt, D. Volpe, N. Hartman, 2018, Cancer Chemotherapy and Pharmacology.

FDA Approval Summary: Nivolumab in Combination with Ipilimumab for the Treatment of Unresectable Malignant Pleural Mesothelioma

Jiang Liu, Martha Donoghue, R. Pazdur, 2021, Clinical Cancer Research.

Adverse effects of tacrolimus in renal transplant patients from living donors.

A. Yousef, N. Bulatova, H. Qosa, 2011, Current drug safety.

Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery

D. Volpe, H. Qosa, Hisham Qosa, 2018, Expert opinion on drug discovery.

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P‐Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1‐linked amyotrophic lateral sclerosis

N. Maragakis, P. Pasinelli, D. Trotti, 2016, Glia.

Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients.

A. Yousef, N. Bulatova, H. Qosa, 2016, Iranian journal of kidney diseases.

FDA Approval Summary: Gilteritinib for Relapsed or Refractory Acute Myeloid Leukemia with a FLT3 Mutation

K. Goldberg, R. Pazdur, A. Farrell, 2021, Clinical Cancer Research.

Transporters as Drug Targets in Neurological Diseases

S. Alqahtani, A. Kaddoumi, H. Qosa, 2016, Clinical pharmacology and therapeutics.

Comparison of the intestinal absorption and bioavailability of γ‐tocotrienol and α‐tocopherol: in vitro, in situ and in vivo studies

P. Sylvester, A. Kaddoumi, Bilal S. Abuasal, 2012, Biopharmaceutics & drug disposition.

Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products.

P. Sylvester, K. E. El Sayed, A. Kaddoumi, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Design and conduct considerations for studies in patients with hepatic impairment

M. Chetty, M. Elmeliegy, P. Ravenstijn, 2022, Clinical and translational science.