J. Sheltzer

发表

Chromosomal instability and aneuploidy as causes of cancer drug resistance.

Jason M. Sheltzer, Devon A. Lukow, Devon A Lukow, 2021, Trends in cancer.

Extensive protein dosage compensation in aneuploid human cancers

Jason M. Sheltzer, Klaske M. Schukken, J. Sheltzer, 2021, bioRxiv.

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

J. Kendall, Jason M. Sheltzer, Z. Storchová, 2020, bioRxiv.

The aneuploidy paradox: costs and benefits of an incorrect karyotype.

Jason M. Sheltzer, A. Amon, J. Sheltzer, 2011, Trends in genetics : TIG.

Aneuploidy Drives Genomic Instability in Yeast

Jason M. Sheltzer, O. Niwa, Y. Hiraoka, 2011, Science.

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

Jason M. Sheltzer, Joan C. Smith, A. Vasudevan, 2020, bioRxiv.

Field-theoretic density estimation for biological sequence space with applications to 5′ splice site diversity and aneuploidy in cancer

David M. McCandlish, J. Kinney, Jason M. Sheltzer, 2021, Proceedings of the National Academy of Sciences.

Non-parametric Bayesian density estimation for biological sequence space with applications to pre-mRNA splicing and the karyotypic diversity of human cancer

David M. McCandlish, J. Kinney, Jason M. Sheltzer, 2020 .

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

L. K. Sørensen, F. Noé, Jason M. Sheltzer, 2021, EBioMedicine.

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

L. K. Sørensen, F. Noé, Jason M. Sheltzer, 2020, bioRxiv.

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

James M. McFarland, A. Letai, Jason M. Sheltzer, 2020, Proceedings of the National Academy of Sciences.

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

W. Kloosterman, Jason M. Sheltzer, Z. Storchová, 2019, eLife.

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer.

J. Kendall, M. Wigler, Jason M. Sheltzer, 2020, Developmental cell.

Single-chromosome Gains Commonly Function as Tumor Suppressors.

Angelika Amon, Jason M. Sheltzer, A. Amon, 2017, Cancer cell.

A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis.

Jason M. Sheltzer, J. Sheltzer, 2013, Cancer research.

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

A. Lin, Jason M. Sheltzer, Christopher J. Giuliano, 2019, Science Translational Medicine.

Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancer

J. Kendall, M. Wigler, Jason M. Sheltzer, 2019, bioRxiv.

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

A. Lin, Jason M. Sheltzer, Christopher J. Giuliano, 2017, eLife.

Oncogene-like addiction to aneuploidy in human cancers

R. Martienssen, Jason M. Sheltzer, Barbora Šalovská, 2023, Science.

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

Jason M. Sheltzer, Joan C. Smith, J. Sheltzer, 2018, eLife.

Aneuploidy as a promoter and suppressor of malignant growth

Jason M. Sheltzer, A. Vasudevan, Erin L. Sausville, 2021, Nature Reviews Cancer.

Increasing gender diversity in the STEM research workforce

J. Steitz, J. Metcalf, L. Villa-komaroff, 2019, Science.

Several consequences of aneuploidy

Jason M. Sheltzer, J. Sheltzer, 2015 .

Aneuploidy in human cancer: new tools and perspectives.

J. Sheltzer, Asad A. Lakhani, Sarah L. Thompson, 2023, Trends in genetics : TIG.

Elite male faculty in the life sciences employ fewer women

Jason M. Sheltzer, Joan C. Smith, J. Sheltzer, 2014, Proceedings of the National Academy of Sciences.

Oncogene-like addiction to aneuploidy in human cancers

R. Martienssen, Jason M. Sheltzer, Barbora Šalovská, 2023, bioRxiv.

Cigarette smoke triggers the expansion of a subpopulation of respiratory epithelial cells that express the SARS-CoV-2 receptor ACE2

Jason M. Sheltzer, Joan C. Smith, J. Sheltzer, 2020 .

Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.

D. Heppner, Erin L. Sausville, Jaweria Bakar, 2023, Cell chemical biology.

A drug’s most potent target is not necessarily the source of its anti-cancer activity

Jason M. Sheltzer, Joan C. Smith, Erin L. Sausville, 2022, bioRxiv.

An elevated rate of whole-genome duplication events in cancers from Black patients

J. Sheltzer, L. M. Brown, R. A. Hagenson, 2023, medRxiv.

Transcriptional consequences of aneuploidy

Maitreya J. Dunham, Jason M. Sheltzer, M. Dunham, 2012, Proceedings of the National Academy of Sciences.

Evolving copy number gains promote tumor expansion and bolster mutational diversification

S. Dehm, Nicole Maeser, Zicheng Wang, 2024, Nature communications.

Single-chromosome aneuploidy commonly functions as a tumor suppressor

Jason M. Sheltzer, A. Amon, Z. Storchová, 2016, bioRxiv.

Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast

Jason M. Sheltzer, A. Amon, H. Blank, 2015, Molecular biology of the cell.

The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response.

Jason M. Sheltzer, M. Rose, J. Sheltzer, 2009, Molecular biology of the cell.

Gender disparities among independent fellows in biomedical research

Jason M. Sheltzer, J. Sheltzer, 2018, Nature Biotechnology.