Francesca Perruccio

发表

Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization.

M. P. Dillon, R. Grotzfeld, Edward G. Lorenzana, 2019, ACS medicinal chemistry letters.

Structure-based design and pre-clinical characterization of selective and orally bioavailable Factor XIa inhibitors: Demonstrating the power of an integrated S1 protease family approach.

V. Hornak, E. Altmann, A. D'arcy, 2020, Journal of medicinal chemistry.

A Common Reference Framework for Analyzing/Comparing Proteins and Ligands. Fingerprints for Ligands And Proteins (FLAP): Theory and Application

Gabriele Cruciani, Jonathan S. Mason, Francesca Perruccio, 2007, J. Chem. Inf. Model..

Case Study 2: Bioisosteric Replacements for the Neurokinin 1 Receptor (NK1R)

F. Perruccio, Francesca Perruccio, 2013 .

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.

Nathan T. Ross, Trixie Wagner, Francesca Perruccio, 2015, Angewandte Chemie.

Ab initio QM/MM modelling of acetyl-CoA deprotonation in the enzyme citrate synthase.

M. W. van der Kamp, A. Mulholland, F. Perruccio, 2007, Journal of molecular graphics & modelling.

High-level QM/MM modelling predicts an arginine as the acid in the condensation reaction catalysed by citrate synthase.

Adrian J Mulholland, Francesca Perruccio, Marc W van der Kamp, 2008, Chemical communications.

Substrate polarization in enzyme catalysis: QM/MM analysis of the effect of oxaloacetate polarization on acetyl‐CoA enolization in citrate synthase

M. W. van der Kamp, A. Mulholland, F. Perruccio, 2007, Proteins.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

H. Waldmann, R. Riedl, F. Bono, 2018, Cell chemical biology.

An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).

A. Wood, P. Dorr, D. Pryde, 2011, Journal of medicinal chemistry.