Hyunah Choo

发表

Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment.

H. Choo, G. Nam, G. Keum, 2013, Bioorganic & medicinal chemistry letters.

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.

H. Choo, H. Rhim, G. Keum, 2014, Bioorganic & medicinal chemistry.

Synthesis of N -Alkyl-Carbazole Derivatives as 5-HT7 R Antagonists

H. Choo, H. Rhim, Jihye Seong, 2018, Bulletin of the Korean Chemical Society.

5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity.

H. Choo, H. Rhim, Jeongeun Lee, 2016, European journal of medicinal chemistry.

Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.

H. Rhim, J. Tae, Youngjae Kim, 2016, European journal of medicinal chemistry.

Aryl Biphenyl‐3‐ylmethylpiperazines as 5‐HT7 Receptor Antagonists

Xi-Ping Huang, B. Roth, Bongjin Moon, 2013, ChemMedChem.

Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.

B. Roth, H. Choo, H. Rhim, 2013, Bioorganic & medicinal chemistry.

4-Aminoethylpiperazinyl aryl ketones with 5-HT₁A/5-HT₇ selectivity.

B. Roth, H. Choo, M. K. Kim, 2012, Bioorganic & medicinal chemistry.

Novel quinazolinone derivatives as 5-HT7 receptor ligands.

H. Choo, Y. Cho, H. Koh, 2008, Bioorganic & medicinal chemistry.

Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists.

H. Choo, G. Nam, J. Hong, 2017, Bioorganic & medicinal chemistry letters.

N ‐(Biphenyl‐3‐ylmethyl)ethanamines as G protein‐biased agonists of 5‐HT 7 R

Bongjin Moon, H. Choo, Byungsun Jeon, 2021, Bulletin of the Korean Chemical Society.

Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor

H. Choo, Byungsun Jeon, Jieon Lee, 2021, Molecules.

Discovery of G Protein-Biased Ligands against 5-HT7R.

H. Choo, Byungsun Jeon, Yakdol Cho, 2021, Journal of medicinal chemistry.

Synthesis of β-Enantiomers of N4-Hydroxy-3′-Deoxy-Pyrimidine Nucleosides and Their Evaluation against Bovine Viral Diarrhoea Virus and Hepatitis C Virus in Cell Culture

L. Stuyver, R. Schinazi, H. Choo, 2004, Antiviral chemistry & chemotherapy.

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model

Ashwini M. Londhe, Y. Cho, A. Pae, 2021, Journal of enzyme inhibition and medicinal chemistry.

Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease

Dong Jin Kim, Soojin Lee, N. Kowall, 2017, Acta Neuropathologica.

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists.

Jae Kyun Lee, Ki Duk Park, H. Choo, 2016, Bioorganic & medicinal chemistry letters.

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.

Bongjin Moon, H. Choo, Y. Cho, 2011, Bioorganic & medicinal chemistry letters.

IKKβ inhibitor identification: a multi-filter driven novel scaffold

Shanthi Nagarajan, Hyunah Choo, Yong Seo Cho, 2010, BMC Bioinformatics.

IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.

Shanthi Nagarajan, Hyunah Choo, Yong Seo Cho, 2009, Bioorganic & medicinal chemistry.

Discovery of G Protein-Biased Antagonists against 5-HT7R.

H. Choo, Byungsun Jeon, Yakdol Cho, 2021, Journal of medicinal chemistry.

3D QSAR pharmacophore model based on diverse IKKβ inhibitors

H. Choo, Y. Cho, A. Pae, 2011, Journal of molecular modeling.

Identification of novel serotonin 2C receptor ligands by sequential virtual screening.

Y. Cho, A. Pae, Asif Ahmed, 2009, Bioorganic & medicinal chemistry.

Novel GSK-3β inhibitors from sequential virtual screening

H. Choo, Y. Cho, A. Pae, 2008 .

5- And 6-exocyclic products, cis-2,3,5-trisubstituted tetrahydrofurans, and cis-2,3,6-trisubstituted tetrahydropyrans via Prins-type cyclization.

Y. Cho, A. Pae, Satish N. Chavre, 2008, The Journal of organic chemistry.

5-Exocyclic products, 2,3,5-trisubstituted tetrahydrofurans via Prins-type cyclization.

H. Choo, Y. Cho, A. Pae, 2006, Organic letters.

Synthesis, anti-HIV activity and molecular modeling studies of carbocyclic and 4'-thionucleosides

H. Choo, Hyunah Choo, 2003 .

2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV)

Yong‐Joo Jeong, Dong-Eun Kim, H. Choo, 2011, European Journal of Medicinal Chemistry.

Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents.

H. Choo, A. Pae, E. Yang, 2010, Bioorganic & medicinal chemistry letters.

In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates.

H. Choo, M. K. Kim, Y. Chong, 2009, Bioorganic & medicinal chemistry.

Comparative QSAR studies on peptide deformylase inhibitors

Hyunah Choo, Yong Seo Cho, Ae Nim Pae, 2007, Journal of molecular modeling.

Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.

R. Schinazi, H. Choo, C. K. Chu, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands

Y. Cho, H. Rhim, H. Koh, 2007 .

Classification of Piperazinylalkylisoxazole Library by Recursive Partitioning

Y. Cho, H. Koh, A. Pae, 2008 .

Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R.

Byungsun Jeon, Yakdol Cho, G. Keum, 2024, ACS chemical neuroscience.

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

M. Otto, L. Stuyver, R. Schinazi, 2002, Antimicrobial Agents and Chemotherapy.

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment

H. Choo, Byungsun Jeon, A. Lee, 2022, International journal of molecular sciences.

Intermolecular double Prins-type cyclization: a facile and efficient synthesis of 1,6-dioxecanes.

Jae Kyun Lee, H. Choo, Y. Cho, 2009, Angewandte Chemie.

N-Acyliminium ion cyclizations of trimethylsilylmethylallenes

H. Choo, Y. Cho, H. Koh, 2006 .

TMSOTf-Promoted Addition of Alkynes to Aldehydes: A Novel Synthesis of Chroman-4-ones

Jae Kyun Lee, H. Choo, Y. Cho, 2008 .

Synthesis of sterically congested bicyclic tetrahydrofurans via Pd-catalyzed cyclization

H. Choo, Y. Cho, A. Pae, 2007 .

Radical cyclization of β-alkoxyacrylates: A formal synthesis of (−)-kumausallene

H. Choo, S. Yoo, E. Lee, 1998 .

Synthesis and Biological Evaluation of Isoxazoline and Isoxazole Derivatives as 5-HT2A and 5-HT2C Receptor Ligands

Y. Cho, H. Koh, A. Pae, 2009 .

Antiviral Activity of Nucleoside Analogues against SARS-coronavirus (SARS-CoV)

S. Olgen, H. Choo, C. K. Chu, 2006, Antiviral chemistry & chemotherapy.

L-nucleosides: antiviral activity and molecular mechanism.

H. Choo, C. K. Chu, Y. Chong, 2002, Current topics in medicinal chemistry.

Discovery of β-Arrestin Biased Ligands of 5-HT7R.

H. Choo, H. Rhim, Jihye Seong, 2018, Journal of medicinal chemistry.

Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and ( 11 C)MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

Jae Kyun Lee, H. Choo, Y. Cho, 2014 .

Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.

H. Choo, Y. Chong, K. Hostetler, 2007, Bioorganic & medicinal chemistry.

Production of deoxygenated high carbon number hydrocarbons from furan condensates: Hydrodeoxygenation of biomass-based oxygenates

D. Suh, J. Jae, Jeong‐Myeong Ha, 2019 .

Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors

H. Choo, H. Lee, Jeong Hyun Jeong, 2022, Journal of enzyme inhibition and medicinal chemistry.

Enhanced Catalytic Activity of (DMSO)2PtCl2 for the Methane Oxidation in the SO3–H2SO4 System

H. Choo, Hyun-Yong Lee, Minserk Cheong, 2018, ACS Catalysis.

Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety.

M. K. Kim, Kwang-Su Park, H. Park, 2010, Journal of medicinal chemistry.

Condensation of furans for the production of diesel precursors: A study on the effects of surface acid sites of sulfonated carbon catalysts

H. Choo, Han‐Ik Joh, D. Suh, 2020 .

Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis

H. Choo, Daeun Lee, Sun Young Kim, 2020, Scientific Reports.

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

Hyunah Choo, Jian Jin, Bryan L. Roth, 2015, ACS chemical neuroscience.

Identification of (-)-Epigallocateshin Gallate Derivatives promoting innate immune activation via 2' 3'-cyclic GMP-AMP-stimulator of interferon genes pathway.

H. Choo, Y. Chong, Sanghee Lee, 2023, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists

Ashwini M. Londhe, H. Choo, A. Pae, 2019, Molecules.

Synthesis and biological evaluation of indane-based fluorescent probes for detection of amyloid-β aggregates in Alzheimer's disease.

Hira Aziz, Sungsu Lim, Sun-Joon Min, 2023, Bioorganic & medicinal chemistry.

Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.

Miso Kang, Seong-Rae Jo, Hyunah Choo, 2023, European journal of medicinal chemistry.

Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.

Ki Duk Park, Bongjin Moon, H. Choo, 2013, Bioorganic & medicinal chemistry.

Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators

H. Choo, Y. Cho, A. Pae, 2017, Molecules.

Synthesis and Biological Evaluation of N 3‐Alkyl‐Thienopyrimidin‐4‐Ones as mGluR1 Antagonists

Minjoo Kim, H. Choo, D. Baek, 2015 .

5-HT3 antagonists under development

H. Choo, Y. Chong, Hyunah Choo, 2010, Expert opinion on investigational drugs.

Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity.

H. Choo, M. K. Kim, Y. Chong, 2015, Organic & biomolecular chemistry.

Conjugation with Phenylalanine Enhances Autophagy-Inducing Activity of (-)-Epigallocatechin Gallate in Hepatic Cells.

H. Choo, M. K. Kim, Y. Chong, 2018, Journal of agricultural and food chemistry.

Chromenylchalcones with inhibitory effects on monoamine oxidase B.

H. Choo, Joong-Hoon Ahn, Y. Lim, 2013, Bioorganic & medicinal chemistry.