D. Nebert

发表

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.

D W Nebert, D. Nebert, A. Puga, 1996, DNA and cell biology.

Dioxin exposure is an environmental risk factor for ischemic heart disease

Bin Wang, Alvaro Puga, D. Nebert, 2007, Cardiovascular Toxicology.

Structure of the mouse cytochrome P1-450 genomic gene.

Y. T. Chen, R. Tukey, D. Nebert, 1983, European journal of biochemistry.

Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.

D. Nebert, F. Carrier, A. Puga, 1992, DNA and cell biology.

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

D. Nebert, F. Carrier, A. Puga, 1992, Molecular and cellular biology.

Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping.

V. Vasiliou, C. Kozak, D. Nebert, 1996, DNA and cell biology.

Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.

A. Fornace, D. Nebert, D. D. Petersen, 1990, Environmental health perspectives.

Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus.

D. Nebert, J. Gielen, J. van Cantfort, 1985, Biochemical pharmacology.

Subcellular localization of membrane-bound aryl-hydrocarbon hydroxylase and NAD(P)H-dependent reductase activities in mouse liver.

D. Nebert, I. Kano, D. Nebert, 1980, European journal of biochemistry.

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

D. Nebert, H. Gelboin, Daniel W. Nebert, 1969, Archives of biochemistry and biophysics.

Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor.

D. Nebert, A. Puga, J. Kerzee, 2002, Free radical biology & medicine.

Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.

D. Nebert, J. Robinson, Joseph R. Robinson, 1974, Molecular pharmacology.

The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.

D. Nebert, S. W. Bigelow, D. Nebert, 1982, Toxicology letters.

Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance.

D. Nebert, Y. Sheen, L. Heilmann, 1988, DNA.

How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress.

D. Nebert, J. Duffy, D. Nebert, 1997, Biochemical pharmacology.

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.

D W Nebert, H. Li, S. Potter, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity.

C. Legraverend, T. Guenthner, D. W. Nebert, 1984, Teratology.

Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro.

D. Nebert, O. Pelkonen, A. Okey, 1979, Journal of the National Cancer Institute.

The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases.

H. Gelboin, D. W. Nebert, N. M. Jensen, 1979, CRC critical reviews in biochemistry.

The Ah receptor: binding specificity only for foreign chemicals?

O. Hankinson, D. Nebert, H. Eisen, 1984, Biochemical pharmacology.

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.

D. Nebert, A. Puga, D. D. Petersen, 1991, Pharmacogenetics.

Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.

C. Kozak, D. Nebert, F. Gonzalez, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Genes encoding drug-metabolizing enzymes: possible role in human disease.

D. Nebert, D. Nebert, 1988, Basic life sciences.

Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis.

M. Miller, T. Dalton, R. McKinnon, 2000, Pharmacogenetics.

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.

D. Nebert, A. Jaiswal, R. Owens, 1989, Molecular endocrinology.

Selective mouse breeding for short ethanol sleep time has led to high levels of hepatic aromatic hydrocarbon (Ah) receptor.

A. C. Collins, A. Collins, D. Nebert, 1989, Biochemical pharmacology.

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction

K. Ozato, D. Nebert, Y. Shirayoshi, 1989, Molecular and cellular biology.

Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica.

D. Nebert, R. Feyereisen, D. Farnsworth, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.

W. Benedict, D. Nebert, N. Considine, 1973, Molecular pharmacology.

Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse.

D. Nebert, G. Lambert, Daniel W. Nebert, 1977, Teratology.

Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.

D. Nebert, K. Setchell, A. Puga, 1999, Chemico-biological interactions.

Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.

D. Nebert, S. Atlas, J. Zweier, 1980, Developmental pharmacology and therapeutics.

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

D. Nebert, O. Mcbride, A. Bale, 1991, American journal of human genetics.

Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.

D. Nebert, A. Maier, T. Denko, 1998, Environmental health perspectives.