M. El‐Gamal

发表

FMS Kinase Inhibitors: Current Status and Future Prospects

Hanan S. Anbar, M. El-Gamal, C. Oh, 2013, Medicinal research reviews.

Discovery of a new potent bisamide FMS kinase inhibitor.

M. El-Gamal, C. Oh, Myung-Ho Jung, 2010, Bioorganic & medicinal chemistry letters.

Recent updates of marine antimicrobial peptides

M. El-Gamal, M. Semreen, S. Abdin, 2018, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety.

M. El-Gamal, C. Oh, M. M. Gamal El-Din, 2015, European journal of medicinal chemistry.

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.

R. El-Awady, J. Sévigny, J. Pelletier, 2022, European journal of medicinal chemistry.

Antiproliferative activity of cycloalkanecarboxamide derivatives possessing sulfonate or sulfamate moiety.

M. El-Gamal, M. Semreen, C. Oh, 2020, Bioorganic chemistry.

Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.

Abduelmula R Abduelkarem, Hanan S. Anbar, M. El-Gamal, 2019, European journal of medicinal chemistry.

Recent updates of carbapenem antibiotics.

M. El-Gamal, Imen Brahim, N. Hisham, 2017, European journal of medicinal chemistry.

Cell‐Based Biological Evaluation of a New Bisamide FMS Kinase Inhibitor Possessing Pyrrolo[3,2‐c]pyridine Scaffold

M. El-Gamal, C. Oh, Mohammed S. Abdel-Maksoud, 2014, Archiv der Pharmazie.

Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors

B. Potter, P. Foster, M. El‐Gamal, 2016, Bioorganic & medicinal chemistry.

Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives against Acanthamoeba castellanii belonging to the T4 genotype.

R. Siddiqui, N. Khan, M. El-Gamal, 2022, Journal of applied microbiology.

A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its Inhibitors

Hanan S. Anbar, M. El-Gamal, Seyed-Omar Zaraei, 2021, Molecules.

New imidazo[2,1-b]thiazole derivatives: synthesis, in vitro anticancer evaluation, and in silico studies.

Yong Sup Lee, M. El-Gamal, C. Oh, 2011, European journal of medicinal chemistry.

Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors

M. El-Gamal, C. Oh, Mohammed S. Abdel-Maksoud, 2018, Medicinal research reviews.

Comparison of D-[ 18 F]FMAU and L-[ 18 F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression

G. Cheon, M. El-Gamal, Tae-Hyun Choi, 2010 .

Radiosynthesis and in vitro evaluation of 1‐(tetrahydro‐5‐hydroxy‐6‐(hydroxymethyl)‐2H‐pyran‐3‐yl)‐5‐[125I]iodouracil: A new potential agent for HSV1‐tk reporter gene monitoring

Jung Young Kim, Eun-Jung Kim, M. El-Gamal, 2010 .

Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.

G. Cheon, S. Lim, C. Choi, 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.

J. Sévigny, J. Pelletier, J. Iqbal, 2020, Bioorganic chemistry.

Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX

J. Sévigny, J. Pelletier, T. Al‐Tel, 2023, Medicinal Chemistry Research.

Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii

R. Siddiqui, N. Khan, M. El-Gamal, 2022, Antibiotics.

Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity.

Young Jik Kwon, Kyung-Tae Lee, K. Lee, 2021, Journal of medicinal chemistry.

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

Hanan S. Anbar, M. El-Gamal, H. Tarazi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Broad-spectrum antiproliferative activity of a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b]thiazole derivatives

C. Oh, M. M. Gamal El-Din, Hyun-Il Kim, 2016, Medicinal Chemistry Research.

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae

R. Siddiqui, N. Khan, M. El-Gamal, 2022, Antibiotics.

Evaluation of imidazo[2,1-b]thiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects.

M. El-Gamal, M. Semreen, Rawan M. Sbenati, 2020, Bioorganic & medicinal chemistry.

Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors.

Kyung-Tae Lee, M. El-Gamal, C. Oh, 2019, Bioorganic chemistry.

Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives.

Kyung-Tae Lee, H. Choi, M. El-Gamal, 2015, European journal of medicinal chemistry.

A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities, and kinase inhibitory effect.

M. El-Gamal, C. Oh, M. M. Gamal El-Din, 2014, European journal of medicinal chemistry.

Design, synthesis, biological evaluation, and modeling studies of novel conformationally-restricted analogues of sorafenib as selective kinase-inhibitory antiproliferative agents against hepatocellular carcinoma cells.

Hanan S. Anbar, M. El-Gamal, Seyed-Omar Zaraei, 2020, European journal of medicinal chemistry.

The latest perspectives of small molecules FMS kinase inhibitors.

T. Al‐Tel, M. El-Gamal, Seyed-Omar Zaraei, 2023, European journal of medicinal chemistry.

Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.

J. Hah, T. Sim, M. El-Gamal, 2009, Bioorganic & medicinal chemistry letters.

Recent advances of pyrrolopyridines derivatives: a patent and literature review

Hanan S. Anbar, M. El-Gamal, M. El‐Gamal, 2017, Expert opinion on therapeutic patents.

Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents.

T. Al‐Tel, Hanan S. Anbar, Seyed-Omar Zaraei, 2024, Bioorganic & medicinal chemistry.

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations

B. Potter, R. Siddiqui, N. Khan, 2023, Antibiotics.

A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation.

B. Potter, R. El-Awady, P. Foster, 2020, Bioorganic & medicinal chemistry.

Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.

J. Iqbal, Hanan S. Anbar, M. El-Gamal, 2019, Bioorganic & medicinal chemistry.

Synthesis of New Tricyclic and Tetracyclic Fused Coumarin Sulfonate Derivatives and Their Inhibitory Effects on LPS‐Induced Nitric Oxide and PGE2 Productions in RAW 264.7 Macrophages: Part 2

Kyung-Tae Lee, Ji-Sun Shin, Woo-Seok Lee, 2016, Archiv der Pharmazie.

A New Series of Cycloalkane-fused Coumarin Sulfonates: Synthesis and In Vitro Antiproliferative Screening

M. El-Gamal, C. Oh, D. Baek, 2016 .

Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.

Kyung-Tae Lee, M. El-Gamal, C. Oh, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors.

M. El-Gamal, Seyed-Omar Zaraei, C. Oh, 2021, European journal of medicinal chemistry.

Design and synthesis of a new series of highly potent RAF kinase-inhibiting triarylpyrazole derivatives possessing antiproliferative activity against melanoma cells.

H. Choi, Mohammad Ashrafuddin Khan, M. El-Gamal, 2016, Future medicinal chemistry.

Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity.

R. El-Awady, T. Al‐Tel, Hanan S. Anbar, 2022, European journal of medicinal chemistry.

Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties

M. El-Gamal, C. Oh, M. M. Gamal El-Din, 2019, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, broad-spectrum antiproliferative activity, and kinase inhibitory effect of triarylpyrazole derivatives possessing arylamides or arylureas moieties.

M. El-Gamal, C. Oh, M. M. Gamal El-Din, 2016, European journal of medicinal chemistry.

New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies.

H. Choi, T. Sim, M. El-Gamal, 2013, European journal of medicinal chemistry.

Antiproliferative Diarylpyrazole Derivatives as Dual Inhibitors of the ERK Pathway and COX‐2

H. Choi, M. El-Gamal, C. Oh, 2013, Chemical biology & drug design.

New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies.

H. Choi, M. El-Gamal, C. Oh, 2011, European journal of medicinal chemistry.

Design, Synthesis, and Antiproliferative Activity of 3,4‐Diarylpyrazole‐1‐carboxamide Derivatives Against Melanoma Cell Line

H. Choi, M. El-Gamal, C. Oh, 2011, Archiv der Pharmazie.

Design and Synthesis of 3-(3-Chloro-4-substituted phenyl)-4-(pyridin-4-yl)-1Hpyrazole- 1-carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line

M. El-Gamal, C. Oh, M. El‐Gamal, 2011 .

Synthesis of 1H‐Pyrazole‐1‐carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line

T. Sim, M. El-Gamal, C. Oh, 2011, Archiv der Pharmazie.

Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma.

J. Hah, T. Sim, J. Choi, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives.

M. El-Gamal, H. Tarazi, C. Oh, 2017, European journal of medicinal chemistry.

Design and Synthesis of an Anticancer Diarylurea Derivative with Multiple-Kinase Inhibitory Effect

M. El-Gamal, C. Oh, M. El‐Gamal, 2012 .

Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents

M. El-Gamal, C. Oh, M. M. Gamal El-Din, 2016, Journal of enzyme inhibition and medicinal chemistry.

PROOF COVER SHEET

C. Oh, K. Yoo, Jungseung Choi, 2022 .

Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study.

Jun‐Seok Lee, M. El-Gamal, Seyed-Omar Zaraei, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Discovery of highly potent V600E-B-RAF kinase inhibitors: Molecular modeling study.

M. El-Gamal, H. Tarazi, C. Oh, 2019, Bioorganic & medicinal chemistry.

Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase

T. Al‐Tel, Hanan S. Anbar, Seyed-Omar Zaraei, 2024, European Journal of Medicinal Chemistry.

Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.

Tamer M. Ibrahim, Seyed-Omar Zaraei, T. Das, 2023, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.

T. Al‐Tel, Hanan S. Anbar, M. El-Gamal, 2022, Bioorganic & medicinal chemistry.

Pyrrolo[3,2-c]pyridine derivatives with potential inhibitory effect against FMS kinase: in vitro biological studies

M. El-Gamal, C. Oh, M. El‐Gamal, 2018, Journal of enzyme inhibition and medicinal chemistry.

Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies.

Hanan S. Anbar, M. El-Gamal, H. Tarazi, 2019, European journal of medicinal chemistry.

Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases

Hanan S. Anbar, Seyed-Omar Zaraei, Mohammad El-Nablaway, 2023, BMC Cancer.

Synthesis, in vitro Antiproliferative and Antiinflammatory Activities, and Kinase Inhibitory effects of New 1,3,4-triarylpyrazole Derivatives.

Kyung-Tae Lee, Ji-Sun Shin, M. El-Gamal, 2017, Anti-cancer agents in medicinal chemistry.

Recent advances with alkaline phosphatase isoenzymes and their inhibitors

J. Iqbal, M. El-Gamal, D. Zaher, 2020, Archiv der Pharmazie.

Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE2 and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages

Kyung-Tae Lee, Ji-Sun Shin, M. El-Gamal, 2018, Molecules.

Current status and future prospects of p38α/MAPK14 kinase and its inhibitors

Hanan S. Anbar, M. El-Gamal, Moustafa M. Madkour, 2021, European Journal of Medicinal Chemistry.

Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE2 Productions and Nitric Oxide in Murine RAW 264.7 Macrophages

Kyung-Tae Lee, M. El-Gamal, C. Oh, 2021, Molecules.

Inhibitory effects of triarylpyrazole derivatives on LPS-induced nitric oxide and PGE2 productions in murine RAW 264.7 macrophages.

Kyung-Tae Lee, Hwi-ho Lee, Ji-Sun Shin, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages

Kyung-Tae Lee, Ji-Sun Shin, M. El-Gamal, 2017, Medicinal Chemistry Research.

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.

J. Sévigny, J. Pelletier, J. Iqbal, 2020, Bioorganic chemistry.

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors.

S. Ullah, J. Sévigny, J. Lecka, 2019, Bioorganic & medicinal chemistry.

An overview of RAF kinases and their inhibitors (2019-2023).

H. Tarazi, Afnan I. Shahin, M. El‐Gamal, 2024, European journal of medicinal chemistry.

Novel anti-Acanthamoebic properties of Raloxifene sulfonate/sulfamate derivatives.

R. Siddiqui, N. Khan, Seyed-Omar Zaraei, 2023, Molecular and biochemical parasitology (Print).

Next generation imidazothiazole and imidazooxazole derivatives as potential drugs against brain-eating amoebae.

R. Siddiqui, Seyed-Omar Zaraei, B. Saeed, 2024, Parasitology research.

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.

J. Sévigny, J. Pelletier, J. Iqbal, 2019, European journal of medicinal chemistry.

Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors.

M. El-Gamal, C. Oh, Shahad K Al-Ameen, 2018, Journal of medicinal chemistry.

Synthesis, in vitro antiproliferative and antiinflammatory activities, and kinase inhibitory effects of a new series of 1,3,4-triarylpyrazole derivatives.

M. El-Gamal, M. El‐Gamal, 2016 .