Theresa J. Roethke

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

D. Holt, D. Behm, S. Douglas, 2013, Bioorganic & medicinal chemistry letters.

Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.

N. Aiyar, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

Development of potent and selective small-molecule human Urotensin-II antagonists.

N. Aiyar, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase

K. Ward, B. R. Smith, J. Mumaw, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

D. Behm, K. Thorneloe, D. Sprecher, 2020, The Journal of Pharmacology and Experimental Therapeutics.

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

H. Alsaid, W. Bao, R. Willette, 2012, Science Translational Medicine.

Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.

B. Smith, K. Ward, Xiaoyang Dong, 2009, Journal of medicinal chemistry.

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Carl A. Brooks, D. Holt, D. Behm, 2018, Journal of medicinal chemistry.

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).

Carl A. Brooks, D. Holt, D. Behm, 2019, ACS medicinal chemistry letters.