Samu Melkko

发表

Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2010, Bioconjugate chemistry.

Isolation of a Small‐Molecule Inhibitor of the Antiapoptotic Protein Bcl‐xL from a DNA‐Encoded Chemical Library

Christoph E. Dumelin, M. Grütter, A. Villa, 2010, ChemMedChem.

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

Christoph E. Dumelin, E. Rizzi, G. De Bellis, 2008, Proceedings of the National Academy of Sciences.

A portable albumin binder from a DNA-encoded chemical library.

Christof Baltes, Samu Melkko, Susanne C. Beck, 2008, Angewandte Chemie.

DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors.

Samu Melkko, Jens Sobek, Dario Neri, 2008, Bioconjugate chemistry.

Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2007, Angewandte Chemie.

Selection of streptavidin binders from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2006, Bioconjugate chemistry.

Encoded self-assembling chemical libraries

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2004, Nature Biotechnology.

Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

M. Renatus, M. Wartmann, S. Melkko, 2020, Journal of medicinal chemistry.

MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.

S. Côté, C. Basson, U. Hassiepen, 2019, Blood.

FXI antibody with a unique binding mode — shows durable effects on markers of anticoagulation in humans Short Title : Novel Factor XI antibody with unique binding mode

Zhiping, Julie, S. Côté, 2019 .

DNA-encoded chemical libraries.

Christoph E. Dumelin, Jörg Scheuermann, Samu Melkko, 2006, Journal of biotechnology.

Selection of catalytically active biotin ligase and trypsin mutants by phage display.

S. Melkko, D. Neri, J. Bertschinger, 2001, Protein engineering.

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

Joshua M. Scurll, M. Gold, A. Dufour, 2015, Nature Communications.

Identification of Protease Substrates in Complex Proteomes by iTRAQ-TAILS on a Thermo Q Exactive Instrument

S. Melkko, U. A. D. Keller, T. Kockmann, 2015 .

Lead discovery by DNA-encoded chemical libraries.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2007, Drug discovery today.

Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease

C. Craik, Gregory M Lee, Kaitlin R Hulce, 2016, ChemMedChem.

Calmodulin as an affinity purification tag.

S. Melkko, D. Neri, Samu Melkko, 2003, Methods in molecular biology.

On the magnitude of the chelate effect for the recognition of proteins by pharmacophores scaffolded by self-assembling oligonucleotides.

Samu Melkko, Dario Neri, Christoph E Dumelin, 2006, Chemistry & biology.