Jose Imperio

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

J. Elstrott, Z. Modrušan, K. Stark, 2020, The Journal of Neuroscience.

Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans.

J. Lubach, H. Wong, Lichuan Liu, 2013, Molecular pharmaceutics.

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

M. Hedehus, J. Eastham‐Anderson, D. Kirkpatrick, 2019, Neurobiology of Disease.

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Melanie A. Huntley, K. Stark, Christopher J. Bohlen, 2021, Neuron.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Jianping Yin, Xingrong Liu, J. Lyssikatos, 2017, Journal of medicinal chemistry.

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

K. Stark, J. Webster, O. Foreman, 2020, Cell Death & Differentiation.

Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

J. Ernst, J. Atwal, Janice A. Maloney, 2019, Alzheimer's Research & Therapy.

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.

Alyaa M. Abdel-Haleem, I. Hötzel, R. Weimer, 2024, Alzheimer's & dementia : the journal of the Alzheimer's Association.

A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity

M. Roose-Girma, A. E. Byrnes, Amy E. Easton, 2023, Cell reports methods.

Characterization of the Selective In Vivo and In Vitro Binding Properties of Crenezumab: Insights into Crenezumab’s Unique Mechanism of Action (P6.174)

J. Atwal, Janice A. Maloney, Yanmei Lu, 2018, Neurology.