Obdulia Rabal

发表

PharmaCoNER: Pharmacological Substances, Compounds and proteins Named Entity Recognition track

Montserrat Marimon, Aitor Gonzalez-Agirre, Martin Krallinger, 2019, EMNLP.

Information Retrieval and Text Mining Technologies for Chemistry.

A. Valencia, Martin Krallinger, A. Lourenço, 2017, Chemical reviews.

The CHEMDNER corpus of chemicals and drugs and its annotation principles

Zhiyong Lu, Karin M. Verspoor, Hongfang Liu, 2015, Journal of Cheminformatics.

Overview of the BioCreative VI chemical-protein interaction Track

Anália Lourenço, Martin Krallinger, Obdulia Rabal, 2017 .

CHEMDNER: The drugs and chemical names extraction challenge

Alfonso Valencia, Martin Krallinger, Florian Leitner, 2015, Journal of Cheminformatics.

Evaluation of chemical and gene/protein entity recognition systems at BioCreative V.5: the CEMP and GPRO patents tracks

Alfonso Valencia, Martín Pérez-Pérez, Anália Lourenço, 2017 .

Overview of the CHEMDNER patents task

Gael Pérez Rodríguez, Martín Pérez Pérez, A. Valencia, 2015 .

Overview of the chemical compound and drug name recognition ( CHEMDNER ) task

A. Valencia, F. Leitner, Martin Krallinger, 2013 .

CHEMDNER challenge overview paper with summary tables of systems performance , methods , features and used resources : •

A. Valencia, F. Leitner, Martin Krallinger, 2014 .

Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells.

O. Rabal, J. Teixidó, S. Grijalvo, 2007, Bioorganic & medicinal chemistry.

In Silico Aptamer Docking Studies: From a Retrospective Validation to a Prospective Case Study'TIM3 Aptamers Binding.

Obdulia Rabal, Julen Oyarzabal, O. Rabal, 2016, Molecular therapy. Nucleic acids.

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.

J. Martinez-Climent, F. Prósper, X. Agirre, 2018, Journal of medicinal chemistry.

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms

J. Martinez-Climent, J. Prieto, O. Rabal, 2017, Haematologica.

Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway [version 1; peer review: 1 approved with reservations]

Steven M. Muskal, V. Wacher, J. Kokai-Kun, 2022 .

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2018, European journal of medicinal chemistry.

Multitarget Approach for the Treatment of Alzheimer`s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) covering diverse selectivity profiles.

O. Rabal, J. Oyarzábal, A. Pineda-Lucena, 2019, ACS chemical neuroscience.

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer’s Disease

O. Rabal, J. Oyarzábal, V. Segura, 2019, Front. Aging Neurosci..

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

G. Perea, R. Franco, O. Rabal, 2015, Clinical Epigenetics.

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice

G. Perea, R. Franco, O. Rabal, 2017, Neuropsychopharmacology.

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.

M. Barbacid, F. Mulero, P. Pizcueta, 2012, Bioorganic & medicinal chemistry letters.

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

M. Barbacid, F. Mulero, P. Pizcueta, 2012, Bioorganic & medicinal chemistry letters.

Novel Scaffold Fingerprint (SFP): Applications in Scaffold Hopping and Scaffold-Based Selection of Diverse Compounds

Fares Ibrahim Amr, O. Rabal, J. Oyarzábal, 2015, J. Chem. Inf. Model..

Imidazo[1,2-a]pyrazines as novel PI3K inhibitors.

O. Rabal, J. Oyarzábal, J. Bischoff, 2012, Bioorganic & medicinal chemistry letters.

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2018, ACS chemical neuroscience.

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2017, ACS chemical neuroscience.

Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases*

O. Rabal, J. Oyarzábal, J. Bischoff, 2009, The Journal of Biological Chemistry.

Dual Targeting of Histone Methyltransferase G9a and DNA‐Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma

R. Urtasun, F. Prósper, J. Zucman‐Rossi, 2019, Hepatology.

Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor

J. Prieto, O. Rabal, J. Oyarzábal, 2017, Oncotarget.

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome

F. Prósper, X. Agirre, O. Rabal, 2017, PloS one.

Computational medicinal chemistry in fragment-based drug discovery: what, how and when.

Manuel Urbano-Cuadrado, Obdulia Rabal, Julen Oyarzabal, 2011, Future Medicinal Chemistry.

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

F. Prósper, G. De Velasco, X. Agirre, 2019, Nature Medicine.

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

J. Martinez-Climent, F. Prósper, J. Martín-Subero, 2017, Nature Communications.

LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes

Martin Krallinger, Salvador Capella-Gutiérrez, Obdulia Rabal, 2017, Nucleic Acids Res..

Biologically Relevant Chemical Space Navigator: From Patent and Structure-Activity Relationship Analysis to Library Acquisition and Design

J. Oyarzábal, Obdulia Rabal, 2012, J. Chem. Inf. Model..

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

O. Rabal, J. Oyarzábal, Manuel Urbano-Cuadrado, 2010, Journal of medicinal chemistry.