James R. Gosset

发表

Cold-Responsive Trigeminal Neurons From Rat TRPM8 mRNA Is Expressed in a Subset of

M. Postlethwaite, A. Dhaka, M. Caterina, 2015 .

A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions

Mingjian Lu, J. Charest, J. Coppeta, 2019, Biotechnology and bioengineering.

A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.

Mingjian Lu, Shyam Sundhar Bale, Kelly Tan, 2019, Lab on a chip.

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.

M. Bunnage, K. Beaumont, D. Leahy, 2012, Bioorganic & medicinal chemistry.

Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

A. Kalgutkar, R. Walsky, B. Feng, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans

M. Postlethwaite, M. Andrews, P. Saintot, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Jeffrey R. Chabot, A. Kalgutkar, L. Buckbinder, 2017, Drug Metabolism and Disposition.

Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

Meindert Danhof, Scott Marshall, Keith Tan, 2009, Pharmaceutical Research.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

P. Loria, T. Rolph, D. Hepworth, 2015, Scientific Reports.

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

A. Carlo, M. Boehm, K. J. Filipski, 2018, ACS medicinal chemistry letters.

Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake

L. Di, D. Erion, Janice A. Brown, 2016, Drug Metabolism and Disposition.