Harinath Chakrapani

发表

A phenacrylate scaffold for tunable thiol activation and release.

H. Chakrapani, R. Sankar, Allimuthu T. Dharmaraja, 2014, Chemical communications.

Small molecule generators of biologically reactive sulfur species

H. Chakrapani, Kundansingh A. Pardeshi, Preeti Chauhan, 2018, RSC advances.

Photocontrolled endogenous reactive oxygen species (ROS) generation.

H. Chakrapani, A. Sharma, H. Singh, 2019, Chemical communications.

Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs.

H. Chakrapani, K. N. Balaji, Siddhesh S. Kamat, 2021, Cell chemical biology.

Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2).

P. Yogeeswari, D. Sriram, H. Chakrapani, 2012, Bioorganic & medicinal chemistry letters.

Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species

N. Chandra, H. Chakrapani, Amit Singh, 2022, Antimicrobial agents and chemotherapy.

Cyclization/hydrosilylation of functionalized 1,6-diynes catalyzed by cationic platinum complexes containing bidentate nitrogen ligands.

H. Chakrapani, R. Widenhoefer, M. Keyerleber, 2002, The Journal of organic chemistry.

Synthesis of carbobicyclic compounds via palladium-catalyzed cyclization/hydrosilylation: evidence for reversible silylpalladation.

R. Widenhoefer, Xiang Wang, Harinath Chakrapani, 2001, The Journal of organic chemistry.

Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex.

H. Chakrapani, Cong Liu, R. Widenhoefer, 2003, Organic letters.

A Chemical Genetic Screen Identifies ABHD12 as an Oxidized Phosphatidylserine Lipase

Dhanashree S. Kelkar, H. Chakrapani, Neelay Mehendale, 2018, Nature Chemical Biology.

An Arm-to-Disarm Strategy to Overcome Phenotypic AMR in Mycobacterium tuberculosis

Piyali Mukherjee, S. Chopra, Grace Kaul, 2024, bioRxiv.

Site-directed delivery of nitric oxide to cancers.

H. Chakrapani, Kavita Sharma, Harinath Chakrapani, 2014, Nitric oxide : biology and chemistry.

INDQ/NO, a bioreductively activated nitric oxide prodrug.

H. Chakrapani, Kundan Sengupta, A. Iyer, 2013, Organic letters.

Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.

H. Chakrapani, J. Saavedra, L. Keefer, 2010, Molecular pharmaceutics.

Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO2) Donors

Satish R. Malwal, Kundansingh A Pardeshi, Harinath Chakrapani, 2019, Chembiochem : a European journal of chemical biology.

Redox‐guided small molecule antimycobacterials

H. Chakrapani, A. Sharma, Amogh Kulkarni, 2018, IUBMB life.

Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release.

D. Saini, H. Chakrapani, Preeti Chauhan, 2017, Organic letters.

Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors.

H. Chakrapani, Satish R. Malwal, Kundansingh A. Pardeshi, 2015, Bioorganic & medicinal chemistry letters.

Benzosulfones as photochemically activated sulfur dioxide (SO2) donors.

H. Chakrapani, Satish R. Malwal, Harinath Chakrapani, 2015, Organic & biomolecular chemistry.

A highly selective sulfinate ester probe for thiol bioimaging.

H. Chakrapani, Satish R. Malwal, K. Sengupta, 2014, Chemical communications.

Benzosultines as sulfur dioxide (SO2) donors.

Satish R. Malwal, Anirban Hazra, Mahesh Gudem, 2013, Organic letters.

Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents.

V. B. Konkimalla, P. Yogeeswari, D. Sriram, 2012, Journal of medicinal chemistry.

Original Contribution

H. Chakrapani, P. Tyagi, Amit Singh, 2022 .

Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones.

H. Chakrapani, Allimuthu T. Dharmaraja, Vinayak S Khodade, 2012, Bioorganic & medicinal chemistry letters.

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

N. Chandra, H. Chakrapani, Amit Singh, 2022, bioRxiv.

“On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor

H. Chakrapani, S. Siddaramappa, Saurabh Mishra, 2017, Chemical science.

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

A. Jadhav, C. Austin, A. Simeonov, 2009, Journal of medicinal chemistry.

Allylic nitro compounds as nitrite donors.

Michael J. Gorczynski, S. B. King, Harinath Chakrapani, 2006, Journal of the American Chemical Society.

FLUORO/NO: A Nitric Oxide Donor with a Fluorescence Reporter

D. Saini, H. Chakrapani, Govindan Ravikumar, 2017, Chembiochem : a European journal of chemical biology.

Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors.

H. Chakrapani, Preeti Chauhan, Govindan Ravikumar, 2017, Organic letters.

Synergistic Activities of Nitric Oxide and Various Drugs

H. Chakrapani, Govindan Ravikumar, Harinath Chakrapani, 2017 .

Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class.

H. Chakrapani, J. Saavedra, L. Keefer, 2012, Forum on immunopathological diseases and therapeutics.

The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline.

H. Chakrapani, J. Saavedra, L. Keefer, 2010, ACS medicinal chemistry letters.

An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug

H. Chakrapani, J. Saavedra, L. Keefer, 2009 .

Improved synthesis of V-PYRRO/NO, a liver-selective nitric oxide prodrug, and analogues

H. Chakrapani, J. Saavedra, L. Keefer, 2009 .

Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors.

H. Chakrapani, Govindan Ravikumar, Allimuthu T. Dharmaraja, 2014, Organic letters.

A small molecule for theraNOstic targeting of cancer cells.

D. Saini, Govindan Ravikumar, Meisam Bagheri, 2017, Chemical communications.

A Small Molecule for Controlled Generation of Peroxynitrite.

H. Chakrapani, A. Kulkarni, K. Sengupta, 2016, Organic letters.