Giuseppe Manfroni

发表

Synthesis of 2‐(Arylamino)ethanethiols via Lewis Acid Catalyzed Aminolysis of 2,2‐Dimethylthiirane as Precursors of the 1,4‐Benzothiazine Nucleus.

Roberto Spogli, S. Sabatini, G. Manfroni, 2009 .

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.

S. Vasudevan, S. Sabatini, G. Manfroni, 2020, ACS medicinal chemistry letters.

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

M. Viveiros, I. Couto, S. Sabatini, 2017, PeerJ.

Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs

G. Manfroni, V. Cecchetti, T. Felicetti, 2020, Journal of medicinal chemistry.

Advantageous Use of Ionic Liquids for the Synthesis of Pharmaceutically Relevant Quinolones

Matteo Tiecco, G. Manfroni, V. Cecchetti, 2018, European Journal of Organic Chemistry.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation

M. Nocchetti, D. Pietrella, R. Pagiotti, 2017 .

Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes.

S. Vasudevan, S. Alonso, S. Sabatini, 2023, European journal of medicinal chemistry.

Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View

G. Manfroni, V. Cecchetti, R. Cannalire, 2020, ChemMedChem.

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

D. Pietrella, S. Sabatini, G. Manfroni, 2020, Journal of enzyme inhibition and medicinal chemistry.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

G. Kaatz, D. Pietrella, S. Sabatini, 2017, Journal of medicinal chemistry.

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.

M. Bolognesi, G. Quérat, G. Manfroni, 2016, Antiviral research.

A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.

G. Manfroni, V. Cecchetti, M. Barreca, 2016, Journal of medicinal chemistry.

A Comprehensive Structural Overview of p38α Mitogen‐Activated Protein Kinase in Complex with ATP‐Site and Non‐ATP‐Site Binders

G. Manfroni, V. Cecchetti, M. Barreca, 2018, ChemMedChem.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Neerja Kaushik-Basu, J. Neyts, P. Leyssen, 2014, Journal of medicinal chemistry.

Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs

A. Marcello, T. Avšič-Županc, G. Manfroni, 2020, PLoS neglected tropical diseases.

Recent Progress toward the Discovery of Small Molecules as Novel Anti-Respiratory Syncytial Virus Agents.

O. Tabarrini, Chiara Sarnari, Giuseppe Manfroni, 2024, Journal of medicinal chemistry.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

G. Quérat, S. Sabatini, G. Manfroni, 2018, European journal of medicinal chemistry.

Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.

L. Goracci, G. Palù, A. Loregian, 2017, European journal of medicinal chemistry.

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

G. Cruciani, G. Palù, A. Loregian, 2015, Journal of medicinal chemistry.

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.

L. Goracci, G. Cruciani, G. Palù, 2013, Journal of medicinal chemistry.

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

G. Kaatz, S. Sabatini, G. Manfroni, 2013, Journal of medicinal chemistry.

From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

S. Sabatini, G. Manfroni, Serena Massari, 2021, ChemMedChem.

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

S. Sabatini, G. Manfroni, Serena Massari, 2020, International journal of molecular sciences.

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

S. Sabatini, G. Manfroni, Serena Massari, 2022, European journal of medicinal chemistry.

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.

K. Kieć‐Kononowicz, G. Kaatz, D. Pietrella, 2018, Journal of medicinal chemistry.

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.

G. Kaatz, B. Schindler, S. Sabatini, 2018, European journal of medicinal chemistry.

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3‐Phenyl‐1,4‐benzothiazine Analogues

G. Kaatz, B. Schindler, S. Sabatini, 2017, ChemMedChem.

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

E. Carosati, G. Kaatz, M. Villarini, 2012, Journal of medicinal chemistry.

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

G. Kaatz, S. Sabatini, D. Patel, 2011, Journal of medicinal chemistry.

Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

G. Cruciani, E. Carosati, G. Kaatz, 2011, Journal of medicinal chemistry.