J. Lategahn

发表

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.

M. Sos, P. Nussbaumer, B. Klebl, 2022, Journal of medicinal chemistry.

Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain.

J. Fletcher, E. Wardelmann, M. Heinrich, 2020, Cancer Discovery.

A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives

S. Laufer, L. M. Lima, E. Barreiro, 2019, Scientific Reports.

Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

E. Smit, E. Felip, W. Engel-Riedel, 2018, Nature Communications.

Organocatalytic, oxidative, intramolecular C-H bond amination and metal-free cross-amination of unactivated arenes at ambient temperature.

Jonas Lategahn, A. Antonchick, R. Samanta, 2011, Angewandte Chemie.

Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.

D. Rauh, T. Grabe, Jonas Lategahn, 2020, ACS medicinal chemistry letters.

Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer.

D. Rauh, M. Keul, J. Lategahn, 2018, Angewandte Chemie.

KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape

J. Sicklick, M. von Mehren, Isabella Klooster, 2024, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

S. Sievers, J. Weisner, M. Müller, 2024, Nature communications.

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Jochen Heil, Franziska Hoffgaard, Julian Engel, 2015, Journal of medicinal chemistry.

Metal-free direct oxidative intermolecular diarylation of anilides at ambient temperature assisted by cascade selective formation of C-C and C-N bonds.

Jonas Lategahn, A. Antonchick, R. Samanta, 2012, Chemical communications.

An Unusual Intramolecular Halogen Bond Guides Conformational Selection.

M. E. Beck, M. D. Polêto, F. Ferreira, 2018, Angewandte Chemie.

Structure Defines Function - Clinically Relevant Mutations in ErbB Kinases.

D. Rauh, Jonas Lategahn, J. Hardick, 2019, Journal of medicinal chemistry.

Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.

J. Hengstler, C. Schultz-Fademrecht, D. Rauh, 2017, Journal of medicinal chemistry.

Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.

C. Schultz-Fademrecht, D. Rauh, S. Bauer, 2017, Journal of medicinal chemistry.

Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.

R. Zahedi, L. Kollipara, C. Schultz-Fademrecht, 2016, Angewandte Chemie.