Terho Lehtimäki

发表

A structural variation reference for medical and population genetics

Tariq Ahmad, Patrick F. Sullivan, Mark I. McCarthy, 2020, Nature.

EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics

Terho Lehtimäki, Mika Ala-Korpela, Mari Karsikas, 2020, International journal of epidemiology.

Model selection for metabolomics: predicting diagnosis of coronary artery disease using automated machine learning

Jason H Moore, Alena Orlenko, Terho Lehtimäki, 2019, Bioinform..

A hybrid data harmonization workflow using word embeddings for the interlinking of heterogeneous cross-domain clinical data structures

Dimitrios I. Fotiadis, Femke Lamers, Vasileios C. Pezoulas, 2021, 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI).

Post-exercise assessment of cardiac repolarization alternans in patients with coronary artery disease using the modified moving average method.

Jari Viik, Terho Lehtimäki, Mika Kähönen, 2009, Journal of the American College of Cardiology.

Heart rate variability derived from exercise ECG in the detection of coronary artery disease

Jaakko Malmivuo, Mari Niemi, Jari Viik, 2007, Physiological measurement.

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Niku Oksala, Markus Perola, Michael Inouye, 2012, PLoS genetics.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Thomas Meitinger, Inês Barroso, Peter Kraft, 2010, Nature Genetics.

Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque

Niku Oksala, Thomas Illig, Terho Lehtimäki, 2014, Scientific Reports.

Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills

Irene Lee, David H. Skuse, Karen N. Conneely, 2013, Proceedings of the National Academy of Sciences.

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos

Markus Perola, Markku Heliövaara, Bogdan Pasaniuc, 2014, Nature Communications.

Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study

Markus Perola, Terho Lehtimäki, Kari M. Mattila, 2002, Journal of Molecular Medicine.

Detection of prostate cancer by an electronic nose: a proof of principle study.

Jukka Lekkala, Pekka Kumpulainen, Antti Roine, 2014, The Journal of urology.

Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study.

Risto Telama, Mika Kivimäki, Terho Lehtimäki, 2010, European heart journal.

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.

Tom R. Gaunt, Jari Kaikkonen, Debbie A Lawlor, 2015, Circulation.

A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

Marko Sysi-Aho, Matej Orešič, Terho Lehtimäki, 2006, PloS one.

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

Andres Metspalu, Mark I. McCarthy, Alex P. Reiner, 2014, PLoS genetics.

Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study.

Richard L. Verrier, Jari Viik, Tiit Kööbi, 2009, Heart rhythm.

Conventional Cardiovascular Risk Factors and Metabolic Syndrome in Predicting Carotid Intima-Media Thickness Progression in Young Adults: The Cardiovascular Risk in Young Finns Study

Terho Lehtimäki, Mika Kähönen, Olli T Raitakari, 2009, Circulation.

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Sylvia Stracke, Alex Doney, Yurii S. Aulchenko, 2012, PLoS genetics.

Exercise-test-related heart rate variability and mortality: the Finnish Cardiovascular Study.

Jari Viik, Tiit Kööbi, Terho Lehtimäki, 2010, International journal of cardiology.

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Jing He, Christian Gieger, Wei Huang, 2015, Nature Genetics.

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

Alun D. Hughes, Markus Perola, Nish Chaturvedi, 2016, Journal of the American College of Cardiology.

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Tariq Ahmad, Patrick F. Sullivan, Andres Metspalu, 2020, Nature Communications.

Discovery and Refinement Supplementary

Christian Gieger, Cisca Wijmenga, Inês Barroso, 2015 .

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Olli Simell, Mark I. McCarthy, Karen L. Mohlke, 2012, Nature Genetics.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Thomas Meitinger, Inês Barroso, Peter Kraft, 2011, Nature Genetics.

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Manuel A. R. Ferreira, Jing Hua Zhao, Nicholas G. Martin, 2012, PloS one.

ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries—Tampere vascular study

Niku Oksala, Terho Lehtimäki, Mika Kähönen, 2009, Annals of medicine.

Genome-wide association analysis identifies susceptibility loci for migraine without aura

Thomas Meitinger, Martin Dichgans, Bertram Müller-Myhsok, 2012, Nature Genetics.

Prevalence of Age-Related Macular Degeneration in Europe

Yara T. E. Lechanteur, Christine Binquet, Elena Prokofyeva, 2017, Ophthalmology.

High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis.

Reino Laatikainen, Jari Laurikka, Terho Lehtimäki, 2012, European heart journal.

Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study

Fatemeh Seyednasrollah, Laura L Elo, Terho Lehtimäki, 2017, Circulation. Cardiovascular genetics.

Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x)

Christian Gieger, Ian J. Deary, He Gao, 2018 .

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.

Niku Oksala, Antti Roine, Terho Lehtimäki, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

He Gao, Tim Kacprowski, Andres Metspalu, 2016, American journal of human genetics.

Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study

Teemu Koivistoinen, Terho Lehtimäki, Mika Kähönen, 2014, Journal of the American Heart Association.

52 Genetic Loci Influencing Myocardial Mass.

Christian Gieger, Thomas Meitinger, Manolis Kellis, 2016, Journal of the American College of Cardiology.

T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test.

Heikki Huikuri, Jari Viik, Willi Kaiser, 2007, European heart journal.

Integrative approaches for large-scale transcriptome-wide association studies

Alkes L. Price, Alexander Gusev, Gaurav Bhatia, 2015 .

Carotid artery intima-media thickness in children with type 1 diabetes.

Terho Lehtimäki, Olli T Raitakari, T. Lehtimäki, 2002, Diabetes.

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

Christian Gieger, Xiaofeng Zhu, Paolo Vineis, 2011, Nature.

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

Jean-Paul Fox, Ian J. Deary, Andres Metspalu, 2014, Behavior genetics.

Directional dominance on stature and cognition in diverse human populations

Laura J. Scott, Claude Bouchard, Christian Gieger, 2015, Nature.

Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies.

Terho Lehtimäki, Mika Kähönen, Pasi Soininen, 2013, Journal of the American College of Cardiology.

DRD2 C32806T modifies the effect of child‐rearing environment on adulthood novelty seeking

Marko Elovainio, Liisa Keltikangas-Järvinen, Terho Lehtimäki, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Markus Perola, Kaisa Silander, Michael Inouye, 2012, Nature Genetics.

Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure

Joel Eriksson, Claes Ohlsson, Mattias Lorentzon, 2013, PLoS genetics.

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Claude Bouchard, Christian Gieger, Tuija Tammelin, 2017 .

Seventy-five genetic loci influencing the human red blood cell

Christian Gieger, Ian J. Deary, Uwe Völker, 2012, Nature.

The association of the apolipoprotein E gene promoter polymorphisms and haplotypes with serum lipid and lipoprotein concentrations.

Terho Lehtimäki, T. Lehtimäki, I. Vuori, 2005, Atherosclerosis.

Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia

Jarmo Hietala, Terho Lehtimäki, Kari M. Mattila, 2006, Neuroscience Letters.

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

Niku Oksala, Peter M. Rothwell, Braxton D. Mitchell, 2014, PLoS genetics.

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

Matti Pirinen, Markus Perola, Taru Tukiainen, 2014, PLoS genetics.

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Mark I. McCarthy, Karen L. Mohlke, Florian Kronenberg, 2013, Diabetes.

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Yadav Sapkota, Thomas Meitinger, Andres Metspalu, 2017, Nature Communications.

Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study.

Mika Kivimäki, Terho Lehtimäki, Mika Kähönen, 2011, International journal of epidemiology.

Apolipoprotein E Phenotypes and Cardiovascular Responses to Experimentally Induced Mental Stress in Adolescent Boys

Heikki Lyytinen, Niklas Ravaja, Liisa Keltikangas-Järvinen, 1997, Journal of Behavioral Medicine.

A genome-wide association meta-analysis identifies new childhood obesity loci

Inês Barroso, Mark I. McCarthy, Philippe Froguel, 2012, Nature Genetics.

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Christian Gieger, Gonçalo Abecasis, He Gao, 2018, Nature Genetics.

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

Terho Lehtimäki, Mika Kähönen, Pasi Soininen, 2013, Diabetes Care.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Christian Gieger, Jianxin Shi, Inês Barroso, 2013, Nature Genetics.

Pulse Wave Velocity Predicts the Progression of Blood Pressure and Development of Hypertension in Young Adults

Teemu Koivistoinen, Terho Lehtimäki, Mika Kähönen, 2018, Hypertension.

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Fernando Pires Hartwig, Claude Bouchard, Christian Gieger, 2018, American journal of human genetics.

Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study

Tero Aittokallio, Laura L. Elo, Terho Lehtimäki, 2010, PLoS genetics.

TPH1 A218C polymorphism and temperament in major depression

Terho Lehtimäki, T. Lehtimäki, N. Mononen, 2013, BMC Psychiatry.

Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change

Samuli Ripatti, Kirsi H. Pietiläinen, Veikko Salomaa, 2014, PLoS medicine.

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

Jie Huang, Uwe Völker, Ming-Huei Chen, 2017, The Journal of clinical investigation.

Rapid and Accurate Detection of Urinary Pathogens by Mobile IMS-Based Electronic Nose: A Proof-of-Principle Study

Jukka Lekkala, Markus Karjalainen, Pekka Kumpulainen, 2014, PloS one.

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

Tuija Tammelin, Taru Tukiainen, Samuli Ripatti, 2012, Diabetes.

Enhanced Predictive Power of Quantitative TWA during Routine Exercise Testing in the Finnish Cardiovascular Study

Jari Viik, Willi Kaiser, Tiit Kööbi, 2009, Journal of cardiovascular electrophysiology.

Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort

Mika P. Tarvainen, Paruthi Pradhapan, Jari Viik, 2014, Front. Physiol..

The Combined Effects of Apolipoprotein E Polymorphism and Low-Density Lipoprotein Cholesterol on Cognitive Performance in Young Adults

Marko Elovainio, Liisa Keltikangas-Järvinen, Sampsa Puttonen, 2003, Neuropsychobiology.

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Christian Gieger, Gonçalo Abecasis, He Gao, 2017, bioRxiv.

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

Markus Perola, Samuli Ripatti, Veikko Salomaa, 2017, American journal of human genetics.

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

Nicholas J Timpson, Clive Osmond, Mark I McCarthy, 2013, Human molecular genetics.

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study

Mika Kivimäki, Terho Lehtimäki, Mika Kähönen, 2008, European heart journal.

MAINTENANCE OF GENETIC VARIATION IN HUMAN PERSONALITY: TESTING EVOLUTIONARY MODELS BY ESTIMATING HERITABILITY DUE TO COMMON CAUSAL VARIANTS AND INVESTIGATING THE EFFECT OF DISTANT INBREEDING

Lars Penke, Jian Yang, Aarno Palotie, 2012, Evolution; international journal of organic evolution.

Distinct variants at LIN28B influence growth in height from birth to adulthood.

Mark I. McCarthy, Clive Osmond, Leena Peltonen, 2010, American journal of human genetics.

Value of leads V4R and CM5 in the detection of coronary artery disease during exercise electrocardiographic test

Jari Hyttinen, Jari Viik, Terho Lehtimäki, 2010, Clinical physiology and functional imaging.

Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study

Wei Chen, Nicholas J. Schork, Leena Peltonen, 2010, PLoS genetics.

Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia.

Christine Binquet, Elena Prokofyeva, Usha Chakravarthy, 2018, Ophthalmology.

Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the young Finns study.

Debbie A Lawlor, Mika Kivimäki, Terho Lehtimäki, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Christian Gieger, Jingyuan Fu, Thomas Meitinger, 2011, Nature Genetics.

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Karen L. Mohlke, Luigi Ferrucci, Florian Kronenberg, 2012, PLoS genetics.

The role of oxytocin receptor gene (OXTR) and mother's emotional warmth in predicting adulthood sociability

Liisa Keltikangas-Järvinen, Terho Lehtimäki, Olli T. Raitakari, 2018 .

A genome‐wide approach to children's aggressive behavior: The EAGLE consortium

Nicholas J Timpson, Harald Grallert, René Veenstra, 2016, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Sylvia Stracke, Christian Gieger, Alex Doney, 2012, Human molecular genetics.

Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement.

Jari Viik, Tiit Kööbi, Terho Lehtimäki, 2010, Heart rhythm.

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Xiaofeng Zhu, Vladan Mijatovic, Inês Barroso, 2016, Nature Genetics.

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.

Kimmo Kaski, Markus Perola, Taru Tukiainen, 2012, Human molecular genetics.

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Jia Jia, Ming-Huei Chen, Eric Boerwinkle, 2016, Nature Genetics.

Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD

Terho Lehtimäki, T. Lehtimäki, N. Mononen, 2011, Neuroscience Letters.