Elisa Toropainen

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Corneal Epithelial Cell Culture Model for Pharmaceutical Studies

E. Toropainen, Elisa Toropainen, 2007 .

Cell culture models of the ocular barriers.

E. Toropainen, A. Urtti, M. Hornof, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Review article Cell culture models of the ocular barriers

A. Urtti, E. Toropainen, M. Hornof, 2005 .

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

H. Tanila, A. Salminen, K. Jokivarsi, 2018, Redox biology.

Pharmacokinetic aspects of retinal drug delivery

A. Urtti, E. D. Amo, A. Rimpelä, 2017, Progress in Retinal and Eye Research.

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery.

A. Urtti, Madhushree Bhattacharya, E. Toropainen, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

P. Caliceti, B. Arango-Gonzalez, S. Bolz, 2021, Pharmaceutics.

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation.

A. Urtti, Eva Ramsay, E. Toropainen, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Mechanisms of protein aggregation in the retinal pigment epithelial cells.

A. Salminen, I. Sorri, K. Kaarniranta, 2010, Frontiers in bioscience.

Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization

A. Salminen, A. Kauppinen, K. Kaarniranta, 2010, Molecular medicine.

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

C. Strachan, A. Urtti, O. Korhonen, 2021, Pharmaceutics.

Understanding dexamethasone kinetics in the rabbit tear fluid: drug release and clearance from solution, suspension and hydrogel formulations.

A. Urtti, C. Alvarez‐Lorenzo, E. Toropainen, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Ocular metabolism and distribution of drugs in the rabbit eye: quantitative assessment after intracameral and intravitreal administrations.

A. Urtti, M. Reinisalo, E. Toropainen, 2021, International journal of pharmaceutics.

Human corneal cell culture models for drug toxicity studies

A. Urtti, K. Järvinen, E. Toropainen, 2016, Drug Delivery and Translational Research.

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa.

Ali Koskela, A. Kauppinen, K. Kaarniranta, 2016, European journal of pharmacology.

A critical assessment of in vitro tissue models for ADME and drug delivery.

A. Subrizi, E. Toropainen, H. Kidron, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region

A. Urtti, J. V. van Hest, E. Toropainen, 2021, Pharmaceutics.

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

A. Koskelainen, K. Kaarniranta, E. Toropainen, 2021, Oxidative medicine and cellular longevity.

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

J. Eriksson, K. Kaarniranta, J. Błasiak, 2021, International journal of molecular sciences.

Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

A. Urtti, H. Dollfus, O. Zelphati, 2021, Pharmaceutics.

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

K. Kaarniranta, E. Toropainen, A. Urtti, 2007, The journal of gene medicine.

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

A. Urtti, E. Toropainen, Kati-Sisko Vellonen, 2021, Pharmaceutics.

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits.

M. Jamei, A. Urtti, E. Toropainen, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye

A. Urtti, Eva Ramsay, E. Toropainen, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model.

A. Urtti, Eva Ramsay, E. Toropainen, 2017, Journal of pharmaceutical sciences.

Ocular Pharmacokinetic Modeling Using Corneal Absorption and Desorption Rates from in Vitro Permeation Experiments with Cultured Corneal Epithelial Cells

A. Urtti, E. Toropainen, Kati-Sisko Vellonen, 2003, Pharmaceutical Research.

Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols.

A. Urtti, S. Auriola, J. Palmgrén, 2002, Journal of chromatography. A.

Culture model of human corneal epithelium for prediction of ocular drug absorption.

A. Urtti, E. Toropainen, A. Urtti, 2001, Investigative ophthalmology & visual science.

Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures.

A. Kauppinen, K. Kaarniranta, E. Toropainen, 2014, Experimental eye research.

Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

A. Urtti, A. Airaksinen, K. Kaarniranta, 2014, Pharmaceutical Research.

Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells.

E. Wylęgała, K. Kaarniranta, E. Toropainen, 2014, Journal of biochemical and pharmacological research.

Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

B. Arango-Gonzalez, M. Ueffing, A. Urtti, 2020, Pharmaceutics.

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits.

A. Urtti, E. D. Amo, Kati-Sisko Vellonen, 2024, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.