Heather M. O’Hagan

发表

Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation

H. O’Hagan, M. Ljungman, M. Paulsen, 2001, Oncogene.

Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2

H. O’Hagan, M. Ljungman, Heather M. O’Hagan, 2004, Oncogene.

RPA and ATR link transcriptional stress to p53

H. O’Hagan, M. Ljungman, M. Paulsen, 2007, Proceedings of the National Academy of Sciences.

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.

S. Baylin, Emily M Bonham, N. Ding, 2016, Journal of molecular cell biology.

Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy.

S. Baylin, J. Hicks, A. D. De Marzo, 2021, Cancer discovery.

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

H. Clevers, Hao Wang, H. O’Hagan, 2022, Microbiology spectrum.

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

S. Baylin, H. O’Hagan, L. van Neste, 2011, Cancer cell.

The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

H. O’Hagan, S. Savant, S. Sriramkumar, 2018, Cancers.

Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Kelly M. McGarvey, S. Baylin, H. O’Hagan, 2009, Cancer research.

Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion

M. Stack, K. Nephew, H. O’Hagan, 2018, Molecular Cancer Research.

Combined epigenetic and metabolic inhibition blocks platinum-induced ovarian cancer stem cell enrichment

K. Nephew, H. O’Hagan, Christiane A. Hassel, 2022, bioRxiv.

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

D. Rusch, H. O’Hagan, Ram Podicheti, 2019, Epigenetics.

Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors

H. O’Hagan, Hongde Li, Jason M. Tennessen, 2018, Cancer & Metabolism.

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

H. O’Hagan, Ahmed H. Ghobashi, Truc T. Vuong, 2023, iScience.

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.

C. Zahnow, S. Baylin, V. Velculescu, 2017, Cancer cell.

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

J. Herman, S. Baylin, E. Gabrielson, 2015, Epigenetics.

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

S. Baylin, H. O’Hagan, H. Mohammad, 2008, PLoS genetics.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

K. Nephew, H. O’Hagan, F. Fang, 2023, bioRxiv.

Chromatin modifications during repair of environmental exposure‐induced DNA damage: A potential mechanism for stable epigenetic alterations

H. O’Hagan, Heather M. O’Hagan, 2014, Environmental and molecular mutagenesis.

The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases.

H. O’Hagan, N. Ding, A. Maiuri, 2017, Mutation research.

Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.

Steven M. Johnson, H. O’Hagan, M. Georgiadis, 2022, Bioorganic & medicinal chemistry.

Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.

Steven M. Johnson, H. O’Hagan, E. Chapman, 2021, Bioorganic & medicinal chemistry.

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer

H. O’Hagan, P. Cole, G. Zentner, 2019, Molecular Cancer Research.

Dietary antioxidants remodel DNA methylation patterns in chronic disease

H. O’Hagan, D. Kitts, B. Stefańska, 2020, British journal of pharmacology.

Increased understanding of the impact of environmental exposures on the epigenome

W. Tang, Heather M. O’Hagan, 2014, Environmental and molecular mutagenesis.

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

K. Nephew, H. O’Hagan, F. Fang, 2022, bioRxiv.

Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer

K. Nephew, H. O’Hagan, Riddhi Sood, 2022, bioRxiv.

JAK2 regulates mismatch repair protein‐mediated epigenetic alterations in response to oxidative damage

H. O’Hagan, S. Savant, N. Ding, 2019, Environmental and molecular mutagenesis.

Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer

Ahmed H. Ghobashi, S. A. Miller, Christopher A. Ladaika, 2024, bioRxiv.

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

D. Rusch, H. O’Hagan, C. Sears, 2017, Cancer research.

Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines

Ludmila V. Danilova, J. Herman, K. Schuebel, 2013, Clinical Cancer Research.

DVL regulation of tissue-specific aromatase transcripts in breast cancer

H. O’Hagan, Heather M. O’Hagan, 2018, OncoTarget.

Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity.

G. Nagaraju, Sikander Hayat, N. Zyromski, 2024, Nature genetics.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

Hao Wang, Cynthia L Sears, H. O’Hagan, 2016, The Journal of infectious diseases.

Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors

Ahmed H. Ghobashi, Christopher A. Ladaika, Heather M. O’Hagan, 2024, Cancers.