Jeffrey T. Mihalic

发表

Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models

J. Jaén, K. Dai, Leping Li, 2013, Pharmacology research & perspectives.

Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.

M. Lindstrom, J. Jaén, K. Dai, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.

J. Jaén, K. Dai, P. Fan, 2011, Bioorganic & medicinal chemistry letters.

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.

M. Lindstrom, J. Jaén, Q. Ye, 2012, Bioorganic & medicinal chemistry letters.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Homologous Phosphonic Acids and Sulfonic Acids as Inhibitors of Lumazine Synthase

A. Bacher, M. Cushman, J. Mihalic, 1999 .

Discovery of a new class of ghrelin receptor antagonists.

M. Lindstrom, Liang Tang, M. Lizarzaburu, 2012, Bioorganic & medicinal chemistry letters.

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

N. Walker, Zhulun Wang, Haoda Xu, 2012, Journal of medicinal chemistry.

Nx-2127, a Degrader of BTK and IMiD Neosubstrates, for the Treatment of B-Cell Malignancies

Dahlia R. Weiss, A. Sands, C. Guiducci, 2020 .