E. DiMauro

发表

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

A. Cheng, J. Newcomb, Xin Huang, 2007, Bioorganic & medicinal chemistry letters.

Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.

E. Dimauro, Brian A Sparling, E. DiMauro, 2017, Bioorganic & medicinal chemistry letters.

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

J. Luther, H. Bregman, Xin Huang, 2016, Nature Structural &Molecular Biology.

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund’s Adjuvant Models of Pain

Zhe Zhang, A. Malmberg, D. Simone, 2015, PloS one.

Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.

H. Bregman, L. Berry, Liyue Huang, 2017, European journal of medicinal chemistry.

The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.

H. Bregman, Xin Huang, Liyue Huang, 2017, Journal of medicinal chemistry.

Convenient synthesis of a reactive ester homoenolate

A. Fry, E. Dimauro, E. DiMauro, 1999 .

Rapid synthesis of 3-amino-imidazopyridines by a microwave-assisted four-component coupling in one pot.

E. Dimauro, J. Kennedy, E. DiMauro, 2007, The Journal of organic chemistry.

Catalysis of the Michael addition reaction by late transition metal complexes of BINOL-derived salens.

M. Kozlowski, P. Carroll, E. Dimauro, 2003, The Journal of organic chemistry.

Development of Bifunctional Salen Catalysts: Rapid, Chemoselective Alkylations of α-Ketoesters

M. Kozlowski, E. Dimauro, E. DiMauro, 2002 .

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.

Dong Liu, R. Fremeau, H. Bregman, 2016, Journal of medicinal chemistry.

Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.

V. Serebrov, M. Altman, Yingzi Yue, 2021, European journal of medicinal chemistry.

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.

Roman Shimanovich, Angel Guzman-Perez, R. Fremeau, 2017, Journal of medicinal chemistry.

Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent NaV1.7 inhibitors.

A. Guzman-Perez, E. Dimauro, Violeta L Yu, 2017, MedChemComm.

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.

X. Fradera, Haiyan Xu, M. Bittinger, 2021, ACS medicinal chemistry letters.

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Xiao Mei Zheng, A. Malmberg, H. Bregman, 2011, Journal of medicinal chemistry.

Salen-derived catalysts containing secondary basic groups in the addition of diethylzinc to aldehydes.

M. Kozlowski, E. Dimauro, E. DiMauro, 2001, Organic letters.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.

Theodore A. Martinot, Michael J. Ardolino, Matthew L. Maddess, 2022, Journal of medicinal chemistry.

Structure-Based Design of Potent and Selective CK1γ Inhibitors.

H. Bregman, J. Newcomb, Xin Huang, 2012, ACS medicinal chemistry letters.

Structure-guided Discovery of Dual-recognition Chemibodies

A. Cheng, Zhulun Wang, Xiaoshan Min, 2018, Scientific Reports.

Structure-guided Discovery of Dual-recognition Chemibodies

A. Cheng, Zhulun Wang, Xiaoshan Min, 2018, Scientific Reports.

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.

Michael J. Ardolino, Karin M. Otte, Matthew J. Fell, 2023, Journal of medicinal chemistry.

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.

R. Fremeau, H. Bregman, M. Chu-Moyer, 2016, ACS medicinal chemistry letters.

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.

H. Bregman, S. McDonough, A. Zou, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

A. Malmberg, H. Bregman, S. McDonough, 2012, Bioorganic & medicinal chemistry letters.