J. Nielsen

发表

Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine

L. Saksida, T. Bussey, T. Robbins, 2018, Translational Psychiatry.

Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

T. Werge, J. Nielsen, M. Didriksen, 2019, Biological Psychiatry.

Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice

T. Werge, P. Celada, J. Nielsen, 2017, Journal of psychiatry & neuroscience : JPN.

Cyclic AMP Control Measured in Two Compartments in HEK293 Cells: Phosphodiesterase KM Is More Important than Phosphodiesterase Localization

J. Nielsen, Karina Matthiesen, J. Nielsen, 2011, PloS one.

Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity.

J. Nielsen, Karina Matthiesen, J. Nielsen, 2009, The Biochemical journal.

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

J. Nielsen, Charles R. Yang, C. Sánchez, 2017, Brain Research.

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

S. Brunak, J. Kleinman, D. Weinberger, 2019, PloS one.

Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.

J. Kehler, C. Christoffersen, J. Nielsen, 2019, Cerebral cortex.

PDE1A inhibition elicits cGMP‐dependent relaxation of rat mesenteric arteries

J. Kehler, C. Christoffersen, J. Nielsen, 2017, British journal of pharmacology.

A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment

Brianne A. Kent, L. Saksida, T. Bussey, 2016, Psychopharmacology.

Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome

Brianne A. Kent, L. Saksida, T. Bussey, 2016, Cerebral cortex.

Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations

D. Geschwind, T. Werge, J. Nielsen, 2019, bioRxiv.

Discovery and Development of 11C-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain

Gunnar Antoni, Mark Lubberink, Anders Wall, 2014, The Journal of Nuclear Medicine.

PDE10A inhibitors: novel therapeutic drugs for schizophrenia.

J. Kehler, J. Nielsen, Jan Kehler, 2011, Current pharmaceutical design.

A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

T. Werge, C. Christoffersen, J. Nielsen, 2017, Translational Psychiatry.

N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.

J. Kehler, M. Langgård, C. Christoffersen, 2013, Bioorganic & medicinal chemistry.

Phosphodiesterase 10A inhibition modulates the sensitivity of the mesolimbic dopaminergic system to d‐amphetamine: involvement of the D1‐regulated feedback control of midbrain dopamine neurons

J. Nielsen, B. Steiniger-Brach, L. Montezinho, 2009, Journal of neurochemistry.

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.

J. Kehler, A. Ritzén, M. Langgård, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors.

J. Kehler, M. Langgård, C. Christoffersen, 2011, Bioorganic & medicinal chemistry.

A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations

Helge B. D. Sørensen, H. Stefánsson, S. Steinberg, 2014, Biological Psychiatry.