Carl S. Rye

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

Alan T. Henley, A. Hayes, S. Sharp, 2016, MedChemComm.

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

G. Morgan, J. Keats, P. Workman, 2018, Clinical Cancer Research.

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

R. V. van Montfort, P. Workman, R. T. te Poele, 2016, Journal of medicinal chemistry.

Privileged Structures and Polypharmacology within and between Protein Families

R. V. van Montfort, P. Workman, Y. Le Bihan, 2018, ACS medicinal chemistry letters.

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.

Brian J. Smith, J. Baell, G. Nikolakopoulos, 2014, ACS medicinal chemistry letters.

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

P. Workman, P. Clarke, Alan T. Henley, 2023, Journal of medicinal chemistry.