Kevin Appourchaux

Negative allosteric modulation of the µ-opioid receptor

J. M. Mathiesen, B. Kobilka, T. Che, 2023, bioRxiv.

A µ-opioid receptor modulator that works cooperatively with naloxone.

J. M. Mathiesen, Weijiao Huang, S. Eans, 2024, Nature.

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

Ruth Hüttenhain, Abdelfattah Faouzi, S. Eans, 2024, ACS central science.

Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

Timothy W. Craven, D. Craik, Roland Hellinger, 2023, Nature communications.