Lesley A Kane

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Adam P. Silverman, Jennifer A. Getz, T. Miyamoto, 2020, Science Translational Medicine.

Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.

K. Scearce-Levie, P. C. Haddick, Joseph W. Lewcock, 2024, Journal of medicinal chemistry.

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

R. Maciuca, K. Scearce-Levie, Y. Ran, 2024, bioRxiv.

SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons

T. Miyamoto, M. Larhammar, J. Dugas, 2023, bioRxiv.

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

M. Larhammar, P. C. Haddick, Joseph W. Lewcock, 2024, eLife.

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

Nicholas E. Propson, T. Sandmann, Joseph W. Lewcock, 2024, Cell.