Paul Gibbons

发表

Structure-guided design of a selective BCL-X(L) inhibitor.

Brian J. Smith, J. Baell, P. Colman, 2013, Nature chemical biology.

Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity.

S. Srivastava, C. Ly, A. Ashkenazi, 2020, ACS medicinal chemistry letters.

Lead identification of novel and selective TYK2 inhibitors.

Adam R. Johnson, Jun Liang, M. Ultsch, 2013, European journal of medicinal chemistry.

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.

Adam R. Johnson, Jun Liang, J. DeVoss, 2013, Journal of medicinal chemistry.

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.

Brian J. Smith, J. Baell, G. Nikolakopoulos, 2014, ACS medicinal chemistry letters.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Jianping Yin, Xingrong Liu, J. Lyssikatos, 2017, Journal of medicinal chemistry.

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015, Journal of medicinal chemistry.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

K. Scearce-Levie, K. Stark, C. Ly, 2015, Journal of medicinal chemistry.

Sca ff old-Hopping and Structure-Based Discovery of Potent , Selective , And Brain Penetrant N ‐ ( 1 H ‐ Pyrazol-3-yl ) pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase ( DLK , MAP 3 K 12 )

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015 .

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.

M. Ultsch, C. Eigenbrot, Leslie B. Lee, 2013, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.

Jane R Kenny, Michael Siu, Deepak Sampath, 2012, Journal of medicinal chemistry.

A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography.

P. Gibbons, C. Hamman, Mengling Wong, 2011, Journal of chromatography. A.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Adam R. Johnson, N. C. Ray, Rohan V Mendonca, 2019, Bioorganic & medicinal chemistry letters.

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Tian Jin, 2012, Journal of medicinal chemistry.