Randall J. Kimple

Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK.

J. M. Shields, R. Kimple, C. Sartor, 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.