Christopher D. Heinen

发表

Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework

Steven E. Brenner, Xi Luo, Lea M. Starita, 2019, Genome Medicine.

Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework

Lea M. Starita, Fergus J. Couch, Jonathan S. Berg, 2019, Genome Medicine.

hXRCC2 Enhances ADP/ATP Processing and Strand Exchange by hRAD51*

Richard Fishel, Christopher D. Heinen, R. Fishel, 2004, Journal of Biological Chemistry.

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Rodney J Scott, John-Paul Plazzer, Finlay Macrae, 2013, Nature Genetics.

Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants Using CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells

Christopher D. Heinen, C. Heinen, Abhijit Rath, 2018, bioRxiv.

Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.

Christopher D. Heinen, C. Heinen, 2016, DNA repair.

Milestones of Lynch syndrome: 1895–2015

Christopher D. Heinen, H. Lynch, C. Heinen, 2015, Nature Reviews Cancer.

Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

Christopher D. Heinen, N. de Wind, L. Rasmussen, 2012, Human mutation.

The predicted truncation from a cancer‐associated variant of the MSH2 initiation codon alters activity of the MSH2‐MSH6 mismatch repair complex

Christopher D. Heinen, C. Heinen, J. Cyr, 2012, Molecular carcinogenesis.

Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

Christopher D. Heinen, C. Heinen, Lene Juel Rasmussen, 2012, Hereditary Cancer in Clinical Practice.

DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication

Christopher D. Heinen, Adam S. Mastrocola, S. Weller, 2011, Journal of Virology.

Human MSH2 (hMSH2) Protein Controls ATP Processing by hMSH2-hMSH6*

Robert A. Forties, Christopher D. Heinen, M. Hingorani, 2011, The Journal of Biological Chemistry.

Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells

Christopher D. Heinen, Alissa M. Resch, B. Graveley, 2011, PloS one.

Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.

Christopher D. Heinen, C. Heinen, 2010, Mutation research.

Hereditary Cancer-associated Missense Mutations in hMSH6 Uncouple ATP Hydrolysis from DNA Mismatch Binding*

Christopher D. Heinen, C. Heinen, Jennifer L. Cyr, 2008, Journal of Biological Chemistry.

DNA Mismatch Repair Proteins Are Required for Efﬁcient Herpes Simplex Virus 1 Replication (cid:1)

Christopher D. Heinen, Adam S. Mastrocola, S. Weller, 2011 .

A calibrated cell-based functional assay to aide classification of MLH1 DNA mismatch repair gene variants

Christopher D. Heinen, S. Tavtigian, C. Heinen, 2021, bioRxiv.

Functional interrogation of Lynch syndrome‐associated MSH2 missense variants via CRISPR‐Cas9 gene editing in human embryonic stem cells

Christopher D. Heinen, H. Reddi, C. Heinen, 2019, Human mutation.

The mismatch repair-dependent DNA damage response: Mechanisms and implications.

Christopher D. Heinen, C. Heinen, D. Gupta, 2019, DNA repair.

Functional and phenotypic consequences of an unusual inversion in MSH2.

Christopher D. Heinen, N. Sabbaghian, Abhijit Rath, 2023, Familial cancer.

The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.

Joanna Groden, Christopher D. Heinen, G. Babcock, 2002, Gastroenterology.

Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy

Christopher D. Heinen, H. Swede, C. Heinen, 2012, Cancer Causes & Control.

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.

Emily J. Greenspan, Christopher D. Heinen, M. O'brien, 2007, Cancer Research.

Increased Frequency of Serrated Aberrant Crypt Foci Among Smokers

Christopher D. Heinen, H. Swede, C. Heinen, 2010, The American Journal of Gastroenterology.

Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer.

Emily J. Greenspan, Christopher D. Heinen, C. Heinen, 2006, Carcinogenesis.

HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions.

Richard Fishel, Christopher D. Heinen, M. Berardini, 2002, Cancer cell.

Loss of mismatch repair promotes a direct selective advantage in human stem cells

Christopher D. Heinen, C. Heinen, Caroline J Guild, 2022, Stem cell reports.

Human Pluripotent Stem Cells Have a Novel Mismatch Repair-dependent Damage Response*

Christopher D. Heinen, C. Heinen, D. Gupta, 2014, The Journal of Biological Chemistry.

Response DamageNovel Mismatch Repair-dependent Human Pluripotent Stem Cells Have a DNA and Chromosomes :

Christopher D. Heinen, C. Heinen, D. Gupta, 2014 .

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Christopher D. Heinen, Yeyejide A. Adeleye, M. Andersen, 2016, Mutation research. Reviews in mutation research.

DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes

Christopher D. Heinen, R. Fishel, C. Heinen, 2002, Cancer biology & therapy.

Cancer Cell Properties

Christopher D. Heinen, C. Heinen, K. Goss, 2001 .

Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways

Christopher D. Heinen, A. Cheng, C. Heinen, 2019, Nature Communications.