Gabriel Helmlinger

Computational Inference of Biological Causal Networks – Analysis of Therapeutic Compound Effects

Jing Yu, Anna Georgieva, Gabriel Helmlinger, 2008 .

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

Luca A. Finelli, Steven Kern, Gabriel Helmlinger, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

Daniel Kaschek, Kirill Peskov, Lulu Chu, 2019, CPT: pharmacometrics & systems pharmacology.

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.

Marc Dellian, Gabriel Helmlinger, Rakesh K Jain, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design

Gabriel Helmlinger, Christina Vasalou, G. Helmlinger, 2015, PloS one.

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Kirill Peskov, Lulu Chu, Gabriel Helmlinger, 2018, Journal of Immunotherapy for Cancer.

Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes

Natal A W van Riel, Gunnar Cedersund, Elin Nyman, 2016, Interface Focus.

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

Rakesh K. Jain, Marc Dellian, Gabriel Helmlinger, 1997, Nature Medicine.

Modeling and simulation of preclinical cardiac safety: towards an integrative framework.

Anna Georgieva, Antoine Soubret, Ruben Bibas, 2009, Drug metabolism and pharmacokinetics.

Solid stress inhibits the growth of multicellular tumor spheroids

Paolo A. Netti, Rakesh K. Jain, Gabriel Helmlinger, 1997, Nature Biotechnology.

An integrated approach for inference and mechanistic modeling for advancing drug development

Anna Georgieva, S. V. Aksenov, Gabriel Helmlinger, 2005, FEBS letters.