Johannes Brussee

发表

Multi-Objective Evolutionary Design of Adenosine Receptor Ligands

Michael T. M. Emmerich, Adriaan P. IJzerman, Eelke van der Horst, 2012, J. Chem. Inf. Model..

Exploring Chemical Substructures Essential for hERG K+ Channel Blockade by Synthesis and Biological Evaluation of Dofetilide Analogues

Johannes Brussee, Shagufta, Dong Guo, 2009, ChemMedChem.

Designing active template molecules by combining computational de novo design and human chemist's expertise.

Adriaan P. IJzerman, Eric-Wubbo Lameijer, Johannes Brussee, 2007 .

Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.

Johannes Brussee, Kenneth A Jacobson, Kai Ye, 2006, Journal of medicinal chemistry.

Mass transfer limitation as a tool to enhance the enantiomeric excess in the enzymatic synthesis of chiral cyanohydrins

Adrie J. J. Straathof, Joseph J. Heijnen, Johannes Brussee, 2001 .

Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.

Judy Lin, Johannes Brussee, A. IJzerman, 2010, Journal of medicinal chemistry.

Designing active template molecules by combining computational de novo design and human chemist's expertise.

Eric-Wubbo Lameijer, Johannes Brussee, A. IJzerman, 2007, Journal of medicinal chemistry.

A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.

Thea Mulder-Krieger, Johannes Brussee, A. IJzerman, 2009, Journal of medicinal chemistry.

Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous-organic biphasic reactor.

Johannes Brussee, Adrie J J Straathof, A. Straathof, 2002, Biotechnology and bioengineering.

Understanding of Molecular Substructures that Contribute to hERG K+ Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues

Adriaan P IJzerman, Olaf Scheel, Johannes Brussee, 2012, ChemMedChem.

2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.

Thea Mulder-Krieger, Johannes Brussee, A. IJzerman, 2004, Journal of medicinal chemistry.

Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.

John Saunders, Zhiyi Yu, Johannes Brussee, 2013, Journal of medicinal chemistry.

Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.

Adriaan P IJzerman, Zhiyi Yu, Johannes Brussee, 2013, Journal of medicinal chemistry.