Bernhardt L Trout

发表

Achieving Continuous Manufacturing in Lyophilization: Technologies and Approaches.

Roberto Pisano, Andrea Arsiccio, Luigi C Capozzi, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Achieving Continuous Manufacturing May 20-21 2014 Continuous Manufacturing Symposium.

Bernhardt L Trout, Clive Badman, 2015, Journal of pharmaceutical sciences.

Machine learning models of antibody-excipient preferential interactions for use in computational formulation design.

Chaitanya Sudrik, Bernhardt L Trout, Theresa K Cloutier, 2020, Molecular pharmaceutics.

Computational tool for the early screening of monoclonal antibodies for their viscosities

Bernhardt L Trout, Li Li, Sandeep Kumar, 2016, mAbs.

Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them May 20-21 2014 Continuous Manufacturing Symposium.

Bernhardt L Trout, Eric Jayjock, Stephen Byrn, 2015, Journal of pharmaceutical sciences.

Production and characterization of carbamazepine nanocrystals by electrospraying for continuous pharmaceutical manufacturing.

Bernhardt L Trout, Gregory C Rutledge, Allan S Myerson, 2011, Journal of pharmaceutical sciences.

Investigation of cosolute-protein preferential interaction coefficients: new insight into the mechanism by which arginine inhibits aggregation.

Bernhardt L Trout, B. Trout, Curtiss P Schneider, 2009, The journal of physical chemistry. B.

The role of nanopore shape in surface-induced crystallization.

Bernhardt L Trout, Takuya Harada, T. A. Hatton, 2011, Nature materials.

Evidence for a size dependent nucleation mechanism in solid state polymorph transformations.

Bernhardt L Trout, Baron Peters, Gregg T Beckham, 2008, The journal of physical chemistry. B.

Surface design for controlled crystallization: the role of surface chemistry and nanoscale pores in heterogeneous nucleation.

Bernhardt L Trout, T. A. Hatton, Allan S Myerson, 2011, Langmuir : the ACS journal of surfaces and colloids.

Extensions to the likelihood maximization approach for finding reaction coordinates.

Bernhardt L Trout, Baron Peters, Gregg T Beckham, 2007, The Journal of chemical physics.

Nucleation of hexagonal ice (Ih) in liquid water.

Bernhardt L Trout, Ravi Radhakrishnan, B. Trout, 2003, Journal of the American Chemical Society.

Modified ligand-exchange for efficient solubilization of CdSe/ZnS quantum dots in water: a procedure guided by computational studies.

Bernhardt L Trout, B. Trout, J. Lee, 2008, Langmuir : the ACS journal of surfaces and colloids.

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies.

Bernhardt L Trout, Veysel Kayser, Bernhard Helk, 2011, Biotechnology journal.

Conformational and Colloidal Stabilities of Isolated Constant Domains of Human Immunoglobulin G and Their Impact on Antibody Aggregation under Acidic Conditions.

Shinya Honda, Bernhardt L Trout, B. Trout, 2015, Molecular pharmaceutics.

A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding

Bernhardt L Trout, Veysel Kayser, Bernhard Helk, 2012, Biotechnology journal.

Comparative oxidation studies of methionine residues reflect a structural effect on chemical kinetics in rhG-CSF.

Bernhardt L Trout, Daniel I. C. Wang, D. Brems, 2006, Biochemistry.

Free energy of binding of a small molecule to an amorphous polymer in a solvent.

Bernhardt L Trout, B. Trout, S. Chunsrivirot, 2011, Langmuir : the ACS journal of surfaces and colloids.

A comprehensive picture of non-site specific oxidation of methionine residues by peroxides in protein pharmaceuticals.

Bernard R Brooks, Bernhardt L Trout, Jhih-Wei Chu, 2004, Journal of pharmaceutical sciences.

A structural and mechanistic study of the oxidation of methionine residues in hPTH(1-34) via experiments and simulations.

Bernhardt L Trout, Jhih-Wei Chu, Daniel I C Wang, 2004, Biochemistry.

Molecular level insight into intra-solvent interaction effects on protein stability and aggregation.

Diwakar Shukla, Bernhardt L Trout, B. Trout, 2011, Advanced drug delivery reviews.

Surface-mediated nucleation in the solid-state polymorph transformation of terephthalic acid.

Cindy Starbuck, Bernhardt L Trout, Narayan Variankaval, 2007, Journal of the American Chemical Society.

Properties of inhibitors of methane hydrate formation via molecular dynamics simulations.

Bernhardt L Trout, J. Tester, B. Anderson, 2005, Journal of the American Chemical Society.

Molecular dynamics simulations and oxidation rates of methionine residues of granulocyte colony-stimulating factor at different pH values.

Bernhardt L Trout, Jhih-Wei Chu, Daniel I. C. Wang, 2004, Biochemistry.

Developability index: a rapid in silico tool for the screening of antibody aggregation propensity.

Bernhardt L Trout, Neeraj J Agrawal, Bernhard Helk, 2012, Journal of pharmaceutical sciences.

Prediction of aggregation prone regions of therapeutic proteins.

Bernhardt L Trout, Veysel Kayser, Bernhard Helk, 2010, The journal of physical chemistry. B.

Protein-associated cation clusters in aqueous arginine solutions and their effects on protein stability and size.

Bernhardt L Trout, Alvin X Han, B. Trout, 2013, ACS chemical biology.

Rational design of solution additives for the prevention of protein aggregation.

Bernhardt L Trout, B. Trout, B. Baynes, 2004, Biophysical journal.

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding

Bernhardt L Trout, Veysel Kayser, Bernhard Helk, 2011, mAbs.

Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression.

Diwakar Shukla, Bernhardt L Trout, B. Trout, 2011, The journal of physical chemistry. B.

A molecular mechanism of hydrolysis of peptide bonds at neutral pH using a model compound.

Bernhardt L Trout, B. Trout, M. Ricci, 2011, The journal of physical chemistry. B.

Nucleation of Molecular Crystals Driven by Relative Information Entropy.

Bernhardt L Trout, Giovanni Ciccotti, Gareth A Tribello, 2018, Journal of chemical theory and computation.

Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20-21, 2014 Continuous Manufacturing Symposium.

Bernhardt L Trout, Eric Jayjock, Stephen Byrn, 2015, Journal of pharmaceutical sciences.

Role of arginine in the stabilization of proteins against aggregation.

Bernhardt L Trout, Daniel I. C. Wang, B. Trout, 2005, Biochemistry.

A computational tool to predict the evolutionarily conserved protein–protein interaction hot‐spot residues from the structure of the unbound protein

Bernhardt L Trout, Neeraj J Agrawal, Bernhard Helk, 2013, FEBS letters.

Achieving continuous manufacturing. May 20-21, 2014 Continuous Manufacturing Symposium.

Bernhardt L Trout, Clive Badman, 2015, Journal of pharmaceutical sciences.

Computational methods to predict therapeutic protein aggregation.

Bernhardt L Trout, Sandeep Kumar, Neeraj J Agrawal, 2012, Methods in molecular biology.

Asparagine deamidation: pH-dependent mechanism from density functional theory.

Bernhardt L Trout, Baron Peters, B. Trout, 2006, Biochemistry.

Molecular Investigation of the Mechanism of Non-Enzymatic Hydrolysis of Proteins and the Predictive Algorithm for Susceptibility.

Bernhardt L Trout, Hardeep S Samra, Geoffrey P. F. Wood, 2016, Biochemistry.

Regulatory Perspectives on Continuous Pharmaceutical Manufacturing: Moving From Theory to Practice: September 26-27, 2016, International Symposium on the Continuous Manufacturing of Pharmaceuticals.

Bernhardt L Trout, Clive Badman, Markus Krumme, 2017, Journal of pharmaceutical sciences.

Aggregation-prone motifs in human immunoglobulin G.

Bernhardt L Trout, Veysel Kayser, Bernhard Helk, 2009, Journal of molecular biology.

Preferential interaction coefficients of proteins in aqueous arginine solutions and their molecular origins.

Diwakar Shukla, Bernhardt L Trout, B. Trout, 2011, The journal of physical chemistry. B.

Quantitative characterization of local protein solvation to predict solvent effects on protein structure.

Bernhardt L Trout, B. Trout, Vincent Vagenende, 2012, Biophysical journal.

On the mechanisms of oxidation of organic sulfides by H2O2 in aqueous solutions.

Bernhardt L Trout, Jhih-Wei Chu, B. Trout, 2004, Journal of the American Chemical Society.

Understanding the synergistic effect of arginine and glutamic acid mixtures on protein solubility.

Diwakar Shukla, Bernhardt L Trout, B. Trout, 2011, The journal of physical chemistry. B.

Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions.

Bernhardt L Trout, Sandeep Kumar, Neeraj J Agrawal, 2011, Journal of pharmaceutical sciences.

Nucleation of crystalline phases of water in homogeneous and inhomogeneous environments.

Bernhardt L Trout, Ravi Radhakrishnan, 2003, Physical review letters.