Adam P. Silverman

发表

Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

Jennifer R. Cochran, Jennifer L. Lahti, Adam P. Silverman, 2009, PLoS Comput. Biol..

Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA

Eric T. Kool, Adam P. Silverman, E. Kool, 2005, Nucleic acids research.

Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization.

Adam P. Silverman, E. Kool, 2007, Advances in clinical chemistry.

Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.

Adam P. Silverman, E. Kool, S. Garforth, 2008, Biochemistry.

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Adam P. Silverman, Jennifer A. Getz, T. Miyamoto, 2020, Science Translational Medicine.

Effects of Spectator Ligands on the Specific Recognition of Intrastrand Platinum-DNA Cross-links by High Mobility Group Box and TATA-binding Proteins* 210

Adam P. Silverman, Seth M. Cohen, S. Lippard, 2001, The Journal of Biological Chemistry.

High-throughput synthesis and screening of platinum drug candidates

Adam P. Silverman, S. Lippard, C. Ziegler, 2000, JBIC Journal of Biological Inorganic Chemistry.

Detecting RNA and DNA with templated chemical reactions.

Adam P. Silverman, E. Kool, 2006, Chemical reviews.

New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA.

Adam P. Silverman, E. Kool, G. Miller, 2008, Bioorganic & medicinal chemistry.

Steric effects in RNA interference: probing the influence of nucleobase size and shape.

Adam P. Silverman, E. Kool, Á. Somoza, 2008, Chemistry.

2.4-Å Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex*

Adam P. Silverman, Seth M. Cohen, S. Lippard, 2002, The Journal of Biological Chemistry.

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

Adam P. Silverman, D. Holtzman, J. Ulrich, 2021, Science Translational Medicine.

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Adam P. Silverman, Jennifer A. Getz, D. Holtzman, 2018, The Journal of clinical investigation.

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Adam P. Silverman, Jennifer A. Getz, Michelle L. Reyzer, 2020, Science Translational Medicine.

Engineered ligand‐based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis

Adam P. Silverman, M. Blumenkranz, J. Cochran, 2017, Bioengineering & translational medicine.

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and αvβ3 integrin

Jennifer L. Lahti, Adam P. Silverman, J. Cochran, 2011, Proceedings of the National Academy of Sciences.

Developing therapeutic proteins by engineering ligand-receptor interactions.

Adam P. Silverman, Jennifer R Cochran, J. Cochran, 2008, Trends in biotechnology.

eveloping therapeutic proteins by ngineering ligand – receptor nteractions

Adam P. Silverman, J. Cochran, O. S. Jones, 2008 .

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.

Jennifer L. Lahti, Adam P. Silverman, A. M. Levin, 2009, Journal of molecular biology.

Quenched probes for highly specific detection of cellular RNAs.

Adam P. Silverman, E. Kool, 2005, Trends in biotechnology.

111In-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis

Adam P. Silverman, R. Kimura, J. Cochran, 2012, Journal of biomedicine & biotechnology.

Optimizing human α-galactosidase for treatment of Fabry disease

Adam P. Silverman, R. Schiffmann, G. Huisman, 2023, Scientific Reports.

Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli.

Adam P. Silverman, E. Kool, M. Goodman, 2007, Biochemistry.

Cystine‐knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

Adam P. Silverman, J. Cochran, Mihalis S. Kariolis, 2011, Journal of molecular recognition : JMR.

Evaluation of a 64Cu-Labeled Cystine-Knot Peptide Based on Agouti-Related Protein for PET of Tumors Expressing αvβ3 Integrin

Adam P. Silverman, S. Gambhir, R. Kimura, 2010, Journal of Nuclear Medicine.

An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract.

Adam P. Silverman, G. Huisman, H. Lee, 2023, Molecular genetics and metabolism.

RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase.

Adam P. Silverman, E. Kool, 2007, Journal of the American Chemical Society.

RNA‐Templated Chemistry in Cells: Discrimination of Escherichia, Shigella and Salmonella Bacterial Strains With a New Two‐Color FRET Strategy

Adam P. Silverman, E. Baron, E. Kool, 2006, Chembiochem : a European journal of chemical biology.

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA

Adam P. Silverman, K. Gadkar, R. Watts, 2024, bioRxiv.

Engineering anti-amyloid antibodies with transferrin receptor targeting improves safety and brain biodistribution

Adam P. Silverman, K. Gadkar, R. Watts, 2022 .