Jean-Pierre Valentin

发表

CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion.

David G Strauss, Rob Wallis, Charles Benson, 2018, Journal of pharmacological and toxicological methods.

Further validation of an automated gait analysis system for applications in safety pharmacology

Jean-Pierre Valentin, Graham Vickery, Helen Prior, 2011 .

In silico toxicology protocols.

Tudor I. Oprea, Naomi L Kruhlak, Lidiya Stavitskaya, 2018, Regulatory toxicology and pharmacology : RTP.

Investigative safety strategies to improve success in drug development

Jean-Pierre Valentin, Catrin Hasselgren, Helga Gerets, 2016, Journal of Medicines Development Sciences.

Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Uwe Marx, Scott Boyer, Mardas Daneshian, 2018, ALTEX.

Proceedings of the symposium on New Frontiers in Safety Pharmacology, organized during the 3rd EPHAR meeting, Lyon, 6–9 July 2001

Jean-Pierre Valentin, 2002 .

Motor coordination using gait analysis: Comparison with beam-walking, rotarod and landing foot splay in rats

Jean-Pierre Valentin, Helen Prior, William S. Redfern, 2010 .

Value of non‐clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

Jean-Pierre Valentin, Tim Hammond, Chris Pollard, 2010, British journal of pharmacology.

Emerging trends and approaches in safety pharmacology

Jean-Pierre Valentin, 2009 .

An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)

Jean-Pierre Valentin, Derek J. Leishman, Helen Prior, 2017 .

Comparison of dog myocytes and purkinje fibres for assessment of drug-induced changes in action potential duration

Jean-Pierre Valentin, Najah Abi-Gerges, C. E. Pollard, 2008 .

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2004, Journal of pharmacological and toxicological methods.

Safety Pharmacology: Past, Present, and Future

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2006 .

Secondary Pharmacodynamic Studies and In vitro Pharmacological Profiling

Jean-Pierre Valentin, Mark Crawford, Jacques Migeon, 2010 .

Non-invasive telemetric electrocardiogram assessment in conscious beagle dogs.

Jean-Pierre Valentin, Helen Prior, Nick McMahon, 2009, Journal of pharmacological and toxicological methods.

Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.

Jean-Pierre Valentin, Hugo M Vargas, Simon Authier, 2017, Journal of pharmacological and toxicological methods.

A framework to assess the translation of safety pharmacology data to humans.

Rob Wallis, Jean-Pierre Valentin, Lorna Ewart, 2009, Journal of pharmacological and toxicological methods.

A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays.

Jean-Pierre Valentin, S. Pettit, J. Koerner, 2009, Journal of pharmacological and toxicological methods.

Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies

Jean-Pierre Valentin, Helen Prior, Nick Edmunds, 2016, Journal of pharmacological and toxicological methods.

Reducing QT liability and proarrhythmic risk in drug discovery and development

Jean-Pierre Valentin, J. Valentin, 2010, British journal of pharmacology.

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics.

Liudmila Polonchuk, Jean-Pierre Valentin, Hugo M Vargas, 2008, Journal of pharmacological and toxicological methods.

The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.

Jean-Pierre Valentin, Lorna Ewart, Pierre Lainée, 2012, Toxicology and applied pharmacology.

An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data

Jean-Pierre Valentin, Stanley E Lazic, S. Lazic, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Application of data mining and visualization techniques for the prediction of drug-induced nausea in man.

Scott Boyer, Jean-Pierre Valentin, Joanna Parkinson, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Functional assessments in repeat-dose toxicity studies: the art of the possible

Jean-Pierre Valentin, Sally Robinson, Lorna Ewart, 2013 .

A Historical View and Vision into the Future of the Field of Safety Pharmacology.

Jean-Pierre Valentin, Alan S Bass, J. Valentin, 2015, Handbook of experimental pharmacology.

Safety and secondary pharmacology: successes, threats, challenges and opportunities.

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2008, Journal of pharmacological and toxicological methods.

Cardiotoxicity associated with targeting kinase pathways in cancer.

Jean-Pierre Valentin, J. Valentin, H. Mellor, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative.

Jean-Pierre Valentin, Hugo M Vargas, Norman Stockbridge, 2009, American heart journal.

Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.

Jean-Pierre Valentin, Matthew J Winter, Stewart F Owen, 2008, Journal of pharmacological and toxicological methods.

Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

Jean-Pierre Valentin, Gary A Gintant, Todd Wisialowski, 2018, British journal of pharmacology.

Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".

Jean-Pierre Valentin, Richard J Weaver, R. Weaver, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report.

Jean-Pierre Valentin, Udo Kraushaar, Elena Dragicevic, 2018, Journal of pharmacological and toxicological methods.

Approaches to seizure risk assessment in preclinical drug discovery.

Jean-Pierre Valentin, Matthew J Winter, Russell A Bialecki, 2009, Drug discovery today.

Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice.

Jean-Pierre Valentin, Dan Heathcote, J. S. McKay, 2011, Journal of pharmacological and toxicological methods.

Acetylcholinesterase: Is there a recommended level of off target activity that can be tolerated and predicted safe?

Jean-Pierre Valentin, Duncan Armstrong, Lyn Rosenbrier Ribeiro, 2014 .

Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?

Rob Wallis, Jean-Pierre Valentin, Matthew J Winter, 2008, Journal of pharmacological and toxicological methods.

Toxicity Testing in the 21st Century Beyond Environmental Chemicals

David M. Reif, Mardas Daneshian, Jean-Pierre Valentin, 2018, ALTEX.

Impact and prevalence of safety pharmacology-related toxicities throughout the pharmaceutical life cycle

Jean-Pierre Valentin, Lorna Ewart, J. Valentin, 2010 .

Secondary Pharmacodynamic Studies andIn Vitro Pharmacological Profiling

Jean-Pierre Valentin, Mark Crawford, Jacques Migeon, 2008 .

I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation.

Jean-Pierre Valentin, Najah Abi-Gerges, Paul G A Volders, 2010, Journal of molecular and cellular cardiology.