Mats O. Karlsson

发表

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Andrew C. Hooker, Chayan Acharya, Gülbeyaz Yildiz Türkyilmaz, 2016, Comput. Methods Programs Biomed..

Comparison of diagnostics using model-based post-processing for fast automated model building

Mats O. Karlsson, Moustafa M. A. Ibrahim, Rikard Nordgren, 2017 .

Analysis of exposure–response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology

Mats O. Karlsson, Maud Delattre, Radojka M. Savic, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Extension of the simplified reference tissue model, to allow different non-specific concentrations in the brain region of interest and the reference region. Application to PET with the radioligand [11C]AZ10419369 displaced by AZD3783 at the serotonin 5HT1B receptor.

Andrew C. Hooker, Mats O. Karlsson, Matts Kågedal, 2014 .

Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Andrew C. Hooker, Mats O. Karlsson, Martin Bergstrand, 2011, The AAPS Journal.

Approaches for modeling within subject variability in pharmacometric count data analysis: dynamic inter-occasion variability and stochastic differential equations

Mats O. Karlsson, Chenhui Deng, Elodie L. Plan, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

A tool for neutrophil guided dose adaptation in chemotherapy

Mats O. Karlsson, Johan E. Wallin, Lena E. Friberg, 2009, Comput. Methods Programs Biomed..

Nonlinearity detection: Advantages of nonlinear mixed-effects modeling

Mats O. Karlsson, E. Niclas Jonsson, Janet R. Wade, 2000, AAPS PharmSci.

The Impact of Censored Observations on Model Fit and Structural Model Discrimination in Nonlinear Mixed Effects Modelling when using Different Estimation Algorithms

Mats O. Karlsson, Åsa Johansson, 2014 .

Variability Attribution for Automated Model Building

Mats O. Karlsson, Moustafa M. A. Ibrahim, Rikard Nordgren, 2019, The AAPS Journal.

Semiparametric Distributions With Estimated Shape Parameters

Mats O. Karlsson, Radojka M. Savic, Klas J. F. Petersson, 2009, Pharmaceutical Research.

Evaluating the evaluations: resampling methods for determining model appropriateness in pharmacometric data analysis

Mats O. Karlsson, E. Niclas Jonsson, Justin J. Wilkins, 2006 .

Translation Between Two Models; Application with Integrated Glucose Homeostasis Models

Mats O. Karlsson, Moustafa M. A. Ibrahim, Maria C. Kjellsson, 2019, Pharmaceutical Research.

Model Description Language (MDL): A Standard for Modeling and Simulation

Richard Kaye, Andrew C. Hooker, Mats O. Karlsson, 2017, CPT: pharmacometrics & systems pharmacology.

Modelling overdispersion and Markovian features in count data

Mats O. Karlsson, Raymond Miller, Elodie L. Plan, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Automated Covariate Model Building Within NONMEM

Mats O. Karlsson, E. Niclas Jonsson, M. Karlsson, 1998, Pharmaceutical Research.

Quantitative Model Diagrams (QMD) : A New Perspective in Model Evaluation

Mats O. Karlsson, Ron J. Keizer, Benjamin Guiastrennec, 2015 .

Optimal design in nonlinear mixed effects models with discrete type data including Categorical, Count, Dropout and Markov models

Andrew C. Hooker, Mats O. Karlsson, Anna Svensson, 2011 .

Multiple Imputation of Missing Covariates in NONMEM and Evaluation of the Method’s Sensitivity to η-Shrinkage

Mats O. Karlsson, Åsa M. Johansson, M. O. Karlsson, 2013, The AAPS Journal.

Evaluating the predictive performance of a population pharmacokinetic model of tacrolimus using a validation dataset based on sparse, adaptive-design data

Mats O. Karlsson, Martin Bergstrand, Johan E. Wallin, 2009 .

Challenges and potential of optimal design in late phase clinical trials through application in Alzheimer’s disease

Andrew C. Hooker, Mats O. Karlsson, Sebastian Ueckert, 2014 .

A search for an ethically attractive dose-finding design for a drug with expected narrow therapeutic interval

Andrew C. Hooker, Mats O. Karlsson, Stefanie Hennig, 2008 .

Comparison of Methods for Handling Missing Covariate Data

Mats O. Karlsson, Åsa M. Johansson, 2013, The AAPS Journal.

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

Andrew C. Hooker, Mats O. Karlsson, Lena E. Friberg, 2018, The AAPS Journal.

Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis

Giuseppe De Nicolao, Andrew C. Hooker, Mats O. Karlsson, 2011, The AAPS Journal.

A novel covariate search method intended for PKPD models with nonparametric parameter distributions

Mats O. Karlsson, Scott Marshall, Paul G. Baverel, 2011 .

Performance of Three Estimation Methods in Repeated Time-to-Event Modeling

Mats O. Karlsson, Elodie L. Plan, Kristin E. Karlsson, 2011, The AAPS Journal.

Open innovation: Towards sharing of data, models and workflows

Mats O. Karlsson, Justin J. Wilkins, Klaus Romero, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparison of Power, Prognosis, and Extrapolation Properties of Four Population Pharmacodynamic Models of HbA1c for Type 2 Diabetes

Mats O. Karlsson, Maria C. Kjellsson, Gustaf J. Wellhagen, 2018, CPT: pharmacometrics & systems pharmacology.

Use of a linearization approximation facilitating stochastic model building

Mats O. Karlsson, Elin M. Svensson, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Model-Based Residual Post-Processing for Residual Model Identification

Mats O. Karlsson, Moustafa M. A. Ibrahim, Rikard Nordgren, 2018, The AAPS Journal.

Randomized dose ranging trials; assessment of statistical power for various design and analysis strategies

Mats O. Karlsson, Kristin E. Karlsson, A. Grahnen, 2004 .

PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool

Andrew C. Hooker, Mats O. Karlsson, Stefanie Hennig, 2012, Comput. Methods Programs Biomed..

Predictive performance of internal and external validation procedures

Mats O. Karlsson, Paul G. Baverel, Kristin E. Karlsson, 2010 .

Multinomial Markov-chain model of sleep architecture in Phase Advanced Subjects

Andrew C. Hooker, Mats O. Karlsson, David J. DeBrota, 2013 .

Tools for Nonlinear Mixed-Effect Model Building and Diagnostics

Andrew C. Hooker, Mats O. Karlsson, E. Niclas Jonsson, 2014 .

Handling Data Below the Limit of Quantification in Mixed Effect Models

Mats O. Karlsson, Martin Bergstrand, M. Karlsson, 2009, The AAPS Journal.

Which matrix is the most reliable to judge the inclusion of covariates: reduction of unexplained parameter variability, increase in explained parameter variability or change in OFV?

Mats O. Karlsson, Stefanie Hennig, 2012 .

Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model

Andrew C. Hooker, Mats O. Karlsson, Joakim Nyberg, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Letter to the editor regarding: “A reduction in between subject variability is not mandatory for selecting a new covariate”

Mats O. Karlsson, Martin Bergstrand, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Model-Based CWRES Analysis for Structural Model Assessment

Mats O. Karlsson, Moustafa M. A. Ibrahim, Sebastian Ueckert, 2018 .

Performance Comparison of Various Maximum Likelihood Nonlinear Mixed-Effects Estimation Methods for Dose–Response Models

France Mentré, Mats O. Karlsson, Elodie L. Plan, 2012, The AAPS Journal.

Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

Andrew C. Hooker, Siv Jönsson, Mats O. Karlsson, 2012, NeuroImage.

A strategy for residual error modeling incorporating scedasticity of variance and distribution shape

Mats O. Karlsson, Martin Bergstrand, Anne-Gaëlle Dosne, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Evaluation of an Extended Grid Method for Estimation Using Nonparametric Distributions

Mats O. Karlsson, Radojka M. Savic, 2009, The AAPS Journal.

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 — Estimating occupancy in the absence of a reference region

Andrew C. Hooker, Christer Halldin, Mats O. Karlsson, 2013, NeuroImage.

Erratum to: Likelihood based approaches to handling data below the quantification limit using NONMEM VI

Mats O. Karlsson, Adrian Dunne, Thomas M. Ludden, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Simultaneous optimal experimental design for in vitro binding parameter estimation

Andrew C. Hooker, Mats O. Karlsson, C. Steven Ernest, 2013, Journal of Pharmacokinetics and Pharmacodynamics.

Standard Error of Empirical Bayes Estimate in NONMEM® VI

Mats O. Karlsson, Radojka M. Savic, Kyun-Seop Bae, 2012, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model

Mats O. Karlsson, Martin Bergstrand, Joseph F. Standing, 2012, The AAPS Journal.

Optimal design of ciprofloxacin in vitro time-kill experiments

Andrew C. Hooker, Mats O. Karlsson, Sha Cao, 2015 .

Evaluation of bias, precision, robustness and runtime for estimation methods in NONMEM 7

Andrew C. Hooker, Mats O. Karlsson, Elodie L. Plan, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Graphical Displays for Modeling Population Data

Mats O. Karlsson, E. Niclas Jonsson, Peter A. Milligan, 2006 .

Likelihood based approaches to handling data below the quantification limit using NONMEM VI

Mats O. Karlsson, Adrian Dunne, Thomas M. Ludden, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

Academic Perspective: Modeling and Simulation as a Teaching Tool

Mats O. Karlsson, Nicholas H. G. Holford, 2002 .

Evaluation of the nonparametric estimation method in nonmem VI: application to real data

Mats O. Karlsson, Radojka M. Savic, Justin J. Wilkins, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Diagnostics for Pharmacometric Models [R package xpose version 0.4.11]

Andrew C. Hooker, Mats O. Karlsson, Sebastian Ueckert, 2020 .

Optimal Design Applied to Hematological Toxicity-Induced Anticancer Treatment

Andrew C. Hooker, Mats O. Karlsson, Joakim Nyberg, 2014 .

Modeling Subpopulations with the $MIXTURE Subroutine in NONMEM: Finding the Individual Probability of Belonging to a Subpopulation for the Use in Model Analysis and Improved Decision Making

Andrew C. Hooker, Mats O. Karlsson, Kristin C. Carlsson, 2009, The AAPS Journal.

Simultaneous optimal experimental design on dose and sample times

Andrew C. Hooker, Mats O. Karlsson, Joakim Nyberg, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression

Mats O. Karlsson, Johan E. Wallin, Lena E. Friberg, 2010, Cancer Chemotherapy and Pharmacology.

Likelihood-Based Diagnostics for Influential Individuals in Non-Linear Mixed Effects Model Selection

Mats O. Karlsson, E. Niclas Jonsson, Sima Sadray, 2004, Pharmaceutical Research.

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

Mats O. Karlsson, Jos H. Beijnen, Ron J. Keizer, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Ximelagatran in extended secondary prevention of venous thromboembolism: Pharmacokinetics, pharmacodynamics and relationships to clinical events

Mats O. Karlsson, Marie Cullberg, Karin Wåhlander, 2006 .

Comparison of proportional and differential odds models for mixed-effects analysis of categorical data

Mats O. Karlsson, Maria C. Kjellsson, E. Niclas Jonsson, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

Characterization of Endogenous G-CSF and the Inverse Correlation to Chemotherapy-Induced Neutropenia in Patients with Breast Cancer Using Population Modeling

Mats O. Karlsson, Lena E. Friberg, H. Lindman, 2014, Pharmaceutical Research.

Serial correlation in optimal design for nonlinear mixed effects models

Andrew C. Hooker, Mats O. Karlsson, Martin Bergstrand, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Approaches to handling pharmacodynamic baseline responses

Mats O. Karlsson, M. Karlsson, Chantaratsamon Dansirikul, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the Digitalis in Acute Atrial Fibrillation trial

Mats O. Karlsson, M. Karlsson, P. Held, 2003, European Journal of Clinical Pharmacology.

Mechanistic Models for Myelosuppression

Mats O. Karlsson, Lena E. Friberg, M. Karlsson, 2003, Investigational New Drugs.

Conditional Weighted Residuals (CWRES): A Model Diagnostic for the FOCE Method

Andrew C. Hooker, Mats O. Karlsson, Christine E. Staatz, 2007, Pharmaceutical Research.

Impact of Omission or Replacement of Data Below the Limit of Quantification on Parameter Estimates in a Two-Compartment Model

Mats O. Karlsson, M. Karlsson, Vincent Duval, 2002, Pharmaceutical Research.

Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies

Mats O. Karlsson, Peter A. Milligan, M. Karlsson, 2008, Antimicrobial Agents and Chemotherapy.

A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim

Andrew C. Hooker, Chayan Acharya, Mats O. Karlsson, 2018, The AAPS Journal.

Population Pharmacokinetics of Rifampin in Pulmonary Tuberculosis Patients, Including a Semimechanistic Model To Describe Variable Absorption

Mats O. Karlsson, Radojka M. Savic, Goonaseelan Pillai, 2008, Antimicrobial Agents and Chemotherapy.

Three new residual error models for population PK/PD analyses

Mats O. Karlsson, Lewis B. Sheiner, Stuart L. Beal, 1995, Journal of Pharmacokinetics and Biopharmaceutics.

Evaluation of Type I Error Rates When Modeling Ordered Categorical Data in NONMEM

Mats O. Karlsson, E. Niclas Jonsson, Ulrika Wählby, 2004, Journal of Pharmacokinetics and Pharmacodynamics.

Improved precision of exposure–response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Andrew C. Hooker, Mats O. Karlsson, Matts Kågedal, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Impact of demographics and disease progression on the relationship between glucose and HbA1c

Mats O. Karlsson, Maria C. Kjellsson, M. Karlsson, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments

Mats O. Karlsson, O. Cars, M. Karlsson, 2006, Antimicrobial Agents and Chemotherapy.

Modeling of red blood cell life-spans in hematologically normal populations

Mats O. Karlsson, Dominik E. Uehlinger, Rocío Lledó-García, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Assessment of Type I Error Rates for the Statistical Sub-model in NONMEM

Mats O. Karlsson, E. Niclas Jonsson, Ulrika Wählby, 2002, Journal of Pharmacokinetics and Pharmacodynamics.

Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models

Mats O. Karlsson, Martin Bergstrand, Joakim Nyberg, 2012, The AAPS Journal.

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion

Mats O. Karlsson, Ulrika S. H. Simonsson, M. Karlsson, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Study Design Selection in Early Clinical Anti‐Hyperglycemic Drug Development: A Simulation Study of Glucose Tolerance Tests

Mats O. Karlsson, Moustafa M. A. Ibrahim, Maria C. Kjellsson, 2018, CPT: pharmacometrics & systems pharmacology.

Multinomial logistic estimation of Markov-chain models for modeling sleep architecture in primary insomnia patients

Giuseppe De Nicolao, Mats O. Karlsson, Stefano Zamuner, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Scaling the time-course of myelosuppression from rats to patients with a semi-physiological model

Mats O. Karlsson, Lena E. Friberg, Marie Sandström, 2010, Investigational New Drugs.

Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms

Siv Jönsson, Mats O. Karlsson, Christer Holmberg, 2008, Pharmacogenetics and genomics.

Methodological Comparison of In Vitro Binding Parameter Estimation: Sequential vs. Simultaneous Non-linear Regression

Andrew C. Hooker, Mats O. Karlsson, C. Steven Ernest, 2010, Pharmaceutical Research.

Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model

Mats O. Karlsson, Robert Bauer, M. Karlsson, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Improved Utilization of ADAS-Cog Assessment Data Through Item Response Theory Based Pharmacometric Modeling

Andrew C. Hooker, Mats O. Karlsson, Elodie L. Plan, 2014, Pharmaceutical Research.

Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis

Mats O. Karlsson, Elin M. Svensson, Jeong-Gun Park, 2013, Antimicrobial Agents and Chemotherapy.

Interchangeability and Predictive Performance of Empirical Tolerance Models

Mats O. Karlsson, Margareta Hammarlund-Udenaes, M. Karlsson, 1999, Clinical pharmacokinetics.

Performance in population models for count data, part I: maximum likelihood approximations

Mats O. Karlsson, Elodie L. Plan, Iñaki F. Trocóniz, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

Mats O. Karlsson, Radojka M. Savic, R. Savic, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Assessment of Actual Significance Levels for Covariate Effects in NONMEM

Mats O. Karlsson, E. Niclas Jonsson, Ulrika Wählby, 2001, Journal of Pharmacokinetics and Pharmacodynamics.

Estimating Bias in Population Parameters for Some Models for Repeated Measures Ordinal Data Using NONMEM and NLMIXED

Siv Jönsson, Mats O. Karlsson, Maria C. Kjellsson, 2004, Journal of Pharmacokinetics and Pharmacodynamics.

Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design

Andrew C. Hooker, Mats O. Karlsson, Joakim Nyberg, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

A Fast Method for Testing Covariates in Population PK/PD Models

Andrew C. Hooker, Mats O. Karlsson, E. Niclas Jonsson, 2011, The AAPS Journal.

Population Pharmacokinetics of Ethambutol in South African Tuberculosis Patients

Siv Jönsson, Mats O. Karlsson, Ulrika S. H. Simonsson, 2011, Antimicrobial Agents and Chemotherapy.

Mechanism-based pharmacokinetic and pharmacodynamic modelling of tesaglitazar in type 2 diabetes patients

Mats O. Karlsson, Bengt Hamrén, M. Karlsson, 2006 .

Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models

Mats O. Karlsson, Maria C. Kjellsson, Brian Corrigan, 2011, Pharmaceutical Research.

The impact of misspecification of residual error or correlation structure on the type I error rate for covariate inclusion

Mats O. Karlsson, Maria C. Kjellsson, Hanna E. Silber, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Assumption Testing in Population Pharmacokinetic Models: Illustrated with an Analysis of Moxonidine Data from Congestive Heart Failure Patients

Mats O. Karlsson, E. Niclas Jonsson, Janet R. Wade, 1998, Journal of Pharmacokinetics and Biopharmaceutics.

Two bootstrapping routines for obtaining imprecision estimates for nonparametric parameter distributions in nonlinear mixed effects models

Mats O. Karlsson, Radojka M. Savic, Paul G. Baverel, 2011, Journal of Pharmacokinetics and Pharmacodynamics.

A Pharmacokinetic-Pharmacodynamic Model for Duodenal Levodopa Infusion

Torgny Groth, Jerker Westin, Mark Dougherty, 2011, Clinical neuropharmacology.

Comparison of some practical sampling strategies for population pharmacokinetic studies

Mats O. Karlsson, E. Niclas Jonsson, Janet R. Wade, 1996, Journal of Pharmacokinetics and Biopharmaceutics.

Use of Prior Information to Stabilize a Population Data Analysis

Mats O. Karlsson, Stuart L. Beal, M. Karlsson, 2002, Journal of Pharmacokinetics and Pharmacodynamics.