Chaim A. Schramm

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Using structural bioinformatics to understand and design protein structures and interactions

Chaim A. Schramm, 2012 .

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection

Lynn Morris, Peter D. Kwong, John R. Mascola, 2016, PLoS Comput. Biol..

AIRR Community Standardized Representations for Annotated Immune Repertoires

Syed Ahmad Chan Bukhari, Steven H. Kleinstein, Brian Corrie, 2018, Front. Immunol..

The ADC API: A Web API for the Programmatic Query of the AIRR Data Commons

Björn Peters, Syed Ahmad Chan Bukhari, Lindsay G. Cowell, 2020, Frontiers in Big Data.

Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data

Syed Ahmad Chan Bukhari, Jamie K. Scott, Chaim A. Schramm, 2017, Front. Immunol..

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Chaim A. Schramm, K. Roskin, T. Kepler, 2013, Nature.

The membrane- and soluble-protein helix-helix interactome: similar geometry via different interactions.

Ilan Samish, Chaim A. Schramm, Daniel W. Kulp, 2015, Structure.

Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions.

Chen Keasar, Ilan Samish, Jason E. Donald, 2012, Structure.

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

Tongqing Zhou, Baoshan Zhang, Sam Darko, 2016, Immunity.

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

Steven H. Kleinstein, Victor Greiff, Nishanth Marthandan, 2019, Front. Immunol..

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2013, Immunity.

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Peter D. Kwong, John R. Mascola, James C. Mullikin, 2017, Front. Immunol..

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design

Chaim A. Schramm, D. Douek, 2018, Front. Immunol..

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2015, Cell.

Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1

Peter D. Kwong, John R. Mascola, Chaim A. Schramm, 2017, Immunological reviews.

SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts

Peter D. Kwong, John R. Mascola, Chaim A. Schramm, 2016, Front. Immunol..

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Lynn Morris, Gwo-Yu Chuang, Peter D. Kwong, 2015, Journal of Virology.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2020, Cell reports.

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.

Chaim A. Schramm, J. Mascola, D. Douek, 2019, Immunity.

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Chaim A. Schramm, T. Kepler, B. Korber, 2020, Science.

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Chaim A. Schramm, T. Kepler, B. Korber, 2020, Science.

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Chaim A. Schramm, J. Mascola, L. Morris, 2018, Nature Communications.

Longitudinal Analysis Reveals Early Development of Three MPER‐Directed Neutralizing Antibody Lineages from an HIV‐1‐Infected Individual

Jonathan R. McDaniel, Chaim A. Schramm, Kenneth H. Zhou, 2019, Immunity.

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

Chaim A. Schramm, J. Mascola, I. Wilson, 2020, Cell host & microbe.

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

Chaim A. Schramm, J. Mascola, D. Douek, 2018, mBio.

sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation

Duncan K. Ralph, William D. Lees, Chaim A. Schramm, 2019, Frontiers in immunology.

Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

Chaim A. Schramm, J. Hoxie, J. Mascola, 2022, PLoS pathogens.

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Chaim A. Schramm, Alexander M Schrager, J. Mascola, 2022, bioRxiv.

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

Chaim A. Schramm, J. Mascola, R. Baric, 2021, bioRxiv.

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants.

Chaim A. Schramm, Alexander M Schrager, J. Mascola, 2022, bioRxiv : the preprint server for biology.

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Chaim A. Schramm, Cinque S. Soto, T. Kepler, 2016, Cell.

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

Lynn Morris, Chaim A. Schramm, John R Mascola, 2015, Nature Medicine.

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Chaim A. Schramm, J. Mascola, R. Baric, 2021, Science.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2019, bioRxiv.

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.

Chaim A. Schramm, T. Kepler, J. Mascola, 2019, Immunity.

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

Chaim A. Schramm, J. Mascola, E. Boritz, 2021, Science.

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

Chaim A. Schramm, J. Mascola, D. Douek, 2021, Immunity.

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

Chaim A. Schramm, J. Mascola, D. Douek, 2018, bioRxiv.

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

Chaim A. Schramm, J. Mascola, E. Boritz, 2021, bioRxiv.

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Chaim A. Schramm, J. Mascola, L. Morris, 2018, Nature Communications.

HIV-1 V 1 V 2 antibody with exceptional potency 5 6

Chaim A. Schramm, B. Haynes, G. Chuang, 2015 .

Vaccine elicitation and structural basis for antibody protection against alphaviruses

Chaim A. Schramm, S. Pletnev, D. Ambrozak, 2023, Cell.

sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation

Mikhail Shugay, Anna Obraztsova, Branden J Olson, 2019, bioRxiv.

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.

Chaim A. Schramm, J. Mascola, D. Douek, 2019, Immunity.

Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates

Chaim A. Schramm, R. Koup, D. Ambrozak, 2023, Nature communications.

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

Chaim A. Schramm, J. Kelsen, C. Deswarte, 2024, Science.