Tuomas P J Knowles

发表

Molecular mechanisms of protein aggregation from global fitting of kinetic models

Michele Vendruscolo, Sara Linse, Georg Meisl, 2016, Nature Protocols.

Microfluidics for Protein Biophysics.

Paolo Arosio, Tuomas P J Knowles, Jérôme Charmet, 2017, Journal of molecular biology.

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.

Michele Vendruscolo, Christopher M Dobson, Michele Perni, 2018, Journal of visualized experiments : JoVE.

Microfluidic approaches for the analysis of protein–protein interactions in solution

Tuomas P J Knowles, William E Arter, Aviad Levin, 2020, Biophysical Reviews.

Atomic structure and hierarchical assembly of a cross-β amyloid fibril

Michele Vendruscolo, Robert G Griffin, Galia T Debelouchina, 2013, Proceedings of the National Academy of Sciences.

Characterization of the nanoscale properties of individual amyloid fibrils

Christopher M Dobson, Tuomas P J Knowles, Mark E Welland, 2006, Proceedings of the National Academy of Sciences.

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Michele Vendruscolo, Sara Linse, Pietro Sormanni, 2017, Science Advances.

Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass

Wenmiao Shu, Christopher M Dobson, Tuomas P J Knowles, 2007, Proceedings of the National Academy of Sciences.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Vendruscolo, Gabriella T Heller, Pietro Sormanni, 2017, Proceedings of the National Academy of Sciences.

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

Sara Linse, Tuomas P J Knowles, Paolo Arosio, 2014, Journal of the American Chemical Society.

Protein aggregation in crowded environments.

Alexander K. Buell, Christopher M Dobson, Tuomas P J Knowles, 2010, Journal of the American Chemical Society.

Protein microgels from amyloid fibril networks.

Alexander K. Buell, Sara Linse, Christopher M Dobson, 2015, ACS nano.

Label-free detection of amyloid growth with microcantilever sensors.

Wenmiao Shu, Hans Peter Lang, Christopher M Dobson, 2008, Nanotechnology.

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.

Michele Vendruscolo, Eugene M Terentjev, Christopher M Dobson, 2011, The Journal of chemical physics.

Crucial role of nonspecific interactions in amyloid nucleation

Daan Frenkel, Tuomas P J Knowles, Anđela Šarić, 2014, Proceedings of the National Academy of Sciences.

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials

Tuomas P J Knowles, Raffaele Mezzenga, R. Mezzenga, 2016, Advanced materials.

Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.

Thomas C T Michaels, Tuomas P J Knowles, T. Knowles, 2014, The Journal of chemical physics.

Hamiltonian Dynamics of Protein Filament Formation.

Michele Vendruscolo, Thomas C T Michaels, Christopher M Dobson, 2016, Physical review letters.

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Mathew H Horrocks, David Klenerman, Tuomas P J Knowles, 2015, Nature Communications.

Metastability of native proteins and the phenomenon of amyloid formation.

Michele Vendruscolo, Gian Gaetano Tartaglia, Christopher M Dobson, 2011, Journal of the American Chemical Society.

A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.

Sara Linse, Tuomas P J Knowles, Ulrich Weininger, 2016, Biophysical journal.

Chemical kinetics for drug discovery to combat protein aggregation diseases.

Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles, 2014, Trends in pharmacological sciences.

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Michele Vendruscolo, Pietro Sormanni, Craig D. Hughes, 2019, Nature Communications.

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.

Sanne Abeln, Daan Frenkel, Tuomas P J Knowles, 2015, Physical review letters.

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

Michele Vendruscolo, Sara Linse, Christopher M Dobson, 2013, Proceedings of the National Academy of Sciences.

From macroscopic measurements to microscopic mechanisms of protein aggregation.

Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles, 2012, Journal of molecular biology.

Surface attachment of protein fibrils via covalent modification strategies.

Christopher M Dobson, Tuomas P J Knowles, Mark E Welland, 2010, The journal of physical chemistry. B.

The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers

Michele Vendruscolo, Sara Linse, Christopher M Dobson, 2015, Nature Structural &Molecular Biology.

Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.

Christopher M Dobson, Tuomas P J Knowles, Mark E Welland, 2011, Biophysical journal.

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

Sara Linse, Georg Meisl, Julius B Kirkegaard, 2014, Proceedings of the National Academy of Sciences.

Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.

Thomas C T Michaels, Tuomas P J Knowles, Paolo Arosio, 2015, The Journal of chemical physics.

Preventing peptide and protein misbehavior

Georg Meisl, Tuomas P J Knowles, Paolo Arosio, 2015, Proceedings of the National Academy of Sciences.

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

Michele Vendruscolo, Sara Linse, Michele Perni, 2016, Science Advances.

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils

Shuichi Takayama, Yang Song, Ho Cheung Shum, 2018, Nature Communications.

Spatial persistence of angular correlations in amyloid fibrils.

Christopher M Dobson, Tuomas P J Knowles, Mark E Welland, 2006, Physical review letters.

Frequency factors in a landscape model of filamentous protein aggregation.

Alexander K. Buell, Jamie R Blundell, Eugene M Terentjev, 2010, Physical review letters.

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.

Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles, 2011, The Journal of chemical physics.

Detailed analysis of the energy barriers for amyloid fibril growth.

Alexander K. Buell, Christopher M Dobson, Tuomas P J Knowles, 2012, Angewandte Chemie.

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

Michele Vendruscolo, Sara Linse, Christopher M Dobson, 2014, Proceedings of the National Academy of Sciences.

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.

Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles, 2011, The Journal of chemical physics.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

Henrik Zetterberg, Mathew H Horrocks, David Klenerman, 2018, Analytical chemistry.