Wilhelm Huisinga

发表

Nonparametric goodness-of-fit testing for parametric covariate models in pharmacometric analyses

Niklas Hartung, Martin Wahl, Abhishake Rastogi, 2020 .

Biomolecular Conformations can be Identified as Metastable Sets of Molecular Dynamics

Wilhelm Huisinga, Christof Schütte, C. Schütte, 2003 .

Adaptive Approach for Modelling Variability in Pharmacokinetics

Wilhelm Huisinga, Illia Horenko, Andrea Y. Weiße, 2006, CompLife.

ADAPTIVE SIMULATION OF HYBRID STOCHASTIC AND DETERMINISTIC MODELS FOR BIOCHEMICAL SYSTEMS

Wilhelm Huisinga, Aurélien Alfonsi, Gabriel Turinici, 2005 .

From simulation data to conformational ensembles: Structure and dynamics‐based methods

Wilhelm Huisinga, Christof Schütte, Frank Cordes, 1999 .

Estimating HIV-1 Fitness Characteristics from Cross-Sectional Genotype Data

Niko Beerenwinkel, Wilhelm Huisinga, Hesam Montazeri, 2014, PLoS Comput. Biol..

Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology

Niklas Hartung, Wilhelm Huisinga, Jana de Wiljes, 2020, CPT: pharmacometrics & systems pharmacology.

From simulation data to conformational ensembles: Structure and dynamics‐based methods

Wilhelm Huisinga, Christof Schütte, Frank Cordes, 1999, J. Comput. Chem..

An Averaging Principle for Fast Degrees of Freedom Exhibiting Long-Term Correlations

Wilhelm Huisinga, Carsten Hartmann, Christof Schütte, 2004, Multiscale Model. Simul..

Software Supported Modelling in Pharmacokinetics

Wilhelm Huisinga, Max von Kleist, Regina Telgmann, 2006, CompLife.

Self-Organizing Maps Combined with Eigenmode Analysis for Automated Cluster Identification

Wilhelm Huisinga, Peter Deuflhard, Tobias Galliat, 1999 .

Hybrid Stochastic-Deterministic Solution of the Chemical Master Equation

Wilhelm Huisinga, Christof Schütte, Juan C. Latorre, 2012, Multiscale Model. Simul..

Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows

Wilhelm Huisinga, Matthias Holschneider, Carsten Beta, 2020, PLoS Comput. Biol..

Quantifying uncertainty, variability and likelihood for ordinary differential equation models

Richard H. Middleton, Wilhelm Huisinga, Andrea Y. Weiße, 2010, BMC Systems Biology.

Adaptive approach for nonlinear sensitivity analysis of reaction kinetics

Wilhelm Huisinga, Illia Horenko, Christof Schütte, 2005, J. Comput. Chem..

Adaptive Discrete Galerkin Methods Applied to the Chemical Master Equation

Peter Deuflhard, Wilhelm Huisinga, Tobias Jahnke, 2008, SIAM J. Sci. Comput..

Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy

Niklas Hartung, Wilhelm Huisinga, Charlotte Kloft, 2019, CPT: pharmacometrics & systems pharmacology.

Error-controlled global sensitivity analysis of ordinary differential equations

Wilhelm Huisinga, Andrea Y. Weiße, W. Huisinga, 2011, J. Comput. Phys..

Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV

Wilhelm Huisinga, Max von Kleist, Stephan Menz, 2010, PLoS Comput. Biol..

A continued learning approach for model‐informed precision dosing: Updating models in clinical practice

Niklas Hartung, Wilhelm Huisinga, Charlotte Kloft, 2021, CPT: pharmacometrics & systems pharmacology.

Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows

Wilhelm Huisinga, Matthias Holschneider, Carsten Beta, 2021, PLoS computational biology.

Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution

Wilhelm Huisinga, Max von Kleist, W. Huisinga, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Metastability of Markovian systems

Wilhelm Huisinga, W. Huisinga, 2001 .

Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia

Zinnia P. Parra-Guillen, Wilhelm Huisinga, Charlotte Kloft, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Extracting Macroscopic Stochastic Dynamics

Wilhelm Huisinga, Andrew M. Stuart, Ch. Schütte, 2003 .

Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values

Wilhelm Huisinga, Philip Lienau, Andreas Reichel, 2009, Journal of biomolecular screening.

Biomolecular Conformations as Metastable Sets of Markov Chains

Wilhelm Huisinga, C. Schütte, W. Huisinga, 2000 .

Pharmacokinetic-pharmacodynamic relationship of NRTIs and its connection to viral escape: an example based on zidovudine.

Wilhelm Huisinga, Max von Kleist, W. Huisinga, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Lumping of physiologically-based pharmacokinetic models and a mechanistic derivation of classical compartmental models

Wilhelm Huisinga, W. Huisinga, S. Pilari, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Toxicokinetics and Metabolism

Wilhelm Huisinga, Ursula Gundert-Remy, Hans Mielke, 2022 .

The virtual laboratory approach to pharmacokinetics: design principles and concepts.

Wilhelm Huisinga, Michael Wulkow, Regina Telgmann, 2006, Drug discovery today.

On Conformational Dynamics induced by Langevin Processes

Wilhelm Huisinga, Christof Schütte, C. Schütte, 2000 .

Transfer Operator Approach to Conformational Dynamics in Biomolecular Systems

Peter Deuflhard, Wilhelm Huisinga, Christof Schütte, 2001 .

A Hybrid Monte Carlo Method for Essential Molecular Dynamics

Alexander Fischer, Peter Deuflhard, Wilhelm Huisinga, 1998 .

Metastability of Diffusion Processes

Wilhelm Huisinga, Sean P. Meyn, S. Meyn, 2003 .

Extracting macroscopic stochastic dynamics: Model problems

Wilhelm Huisinga, Andrew M. Stuart, Christof Schütte, 2003 .