Jan Brezovsky

发表

PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations

Jaroslav Bendl, Jan Stourac, Ondrej Salanda, 2014, PLoS Comput. Biol..

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Baker, Jaroslav Bendl, Jan Brezovsky, 2015, PLoS Comput. Biol..

CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories

Jan Stourac, Antonín Pavelka, Jan Brezovsky, 2018, Bioinform..

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

Antonín Pavelka, Jan Brezovsky, Jirí Damborský, 2012, PLoS Comput. Biol..

CAVER Analyst 1.0: graphic tool for interactive visualization and analysis of tunnels and channels in protein structures

Antonín Pavelka, Jan Brezovsky, Jirí Damborský, 2014, Bioinform..

PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions

Jaroslav Bendl, Jan Stourac, Jaroslav Zendulka, 2016, PLoS Comput. Biol..

CAVER: Algorithms for Analyzing Dynamics of Tunnels in Macromolecules

Antonín Pavelka, Jan Brezovsky, Jirí Damborský, 2016, IEEE/ACM Transactions on Computational Biology and Bioinformatics.

Mechanism-Based Discovery of Novel Substrates of Haloalkane Dehalogenases Using in Silico Screening

Jan Brezovsky, Zbynek Prokop, Jiri Damborsky, 2015, J. Chem. Inf. Model..

FireProt: web server for automated design of thermostable proteins

Jaroslav Bendl, Jan Stourac, Jaroslav Zendulka, 2017, Nucleic Acids Res..

CaverDock: A Novel Method for the Fast Analysis of Ligand Transport

Ludek Matyska, Jan Brezovsky, David Bednar, 2018, IEEE/ACM Transactions on Computational Biology and Bioinformatics.

Software tools for identification, visualization and analysis of protein tunnels and channels.

Jan Brezovsky, Artur Gora, Jiri Damborsky, 2013, Biotechnology advances.

Computational tools for designing smart libraries.

Jaroslav Bendl, Jan Brezovsky, Eva Sebestova, 2014, Methods in molecular biology.

Tools and data services registry: a community effort to document bioinformatics resources

Silvio C. E. Tosatto, Anthony Bretaudeau, Burkhard Rost, 2015, Nucleic Acids Res..

HotSpot Wizard 2.0: automated design of site-specific mutations and smart libraries in protein engineering

Jaroslav Bendl, Jan Stourac, Jan Brezovsky, 2016, Nucleic Acids Res..

Substrate specificity of haloalkane dehalogenases.

Jan Brezovsky, Jiri Damborsky, Eva Chovancova, 2011, The Biochemical journal.

Expansion of Access Tunnels and Active‐Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents

Jan Sykora, Jan Brezovsky, Zbynek Prokop, 2013, Chembiochem : a European journal of chemical biology.

Enzyme Tunnels and Gates As Relevant Targets in Drug Design

Jan Brezovsky, Zbynek Prokop, Lukas Daniel, 2017, Medicinal research reviews.

Engineering a de Novo Transport Tunnel

Jan Brezovsky, Zbynek Prokop, Artur Gora, 2016 .

Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear β-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites.

Jan Brezovsky, Zbynek Prokop, David Bednar, 2017, Angewandte Chemie.

Impact of the access tunnel engineering on catalysis is strictly ligand‐specific

Jan Brezovsky, Zbynek Prokop, Radka Chaloupkova, 2018, The FEBS journal.

Computational tools for designing and engineering enzymes.

Jan Brezovsky, Jiri Damborsky, J. Damborský, 2014, Current opinion in chemical biology.

Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling

Jan Brezovsky, Zbynek Prokop, Radka Chaloupkova, 2017, J. Chem. Inf. Model..

Computer-assisted engineering of the synthetic pathway for biodegradation of a toxic persistent pollutant.

Jan Brezovsky, Zbynek Prokop, Pavel Dvorak, 2014, ACS synthetic biology.

Discovery of Novel Haloalkane Dehalogenase Inhibitors

Jan Brezovsky, Zbynek Prokop, Lukas Daniel, 2016, Applied and Environmental Microbiology.

Maximizing the Efficiency of Multienzyme Process by Stoichiometry Optimization

Jan Brezovsky, Zbynek Prokop, Pavel Dvorak, 2014, Chembiochem : a European journal of chemical biology.

Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel.

Jan Brezovsky, Zbynek Prokop, Eva Sebestova, 2013, Angewandte Chemie.

Computational tools for designing and engineering biocatalysts.

Jan Brezovsky, Jiri Damborsky, J. Damborský, 2009, Current opinion in chemical biology.

Dynamics and hydration explain failed functional transformation in dehalogenase design.

Jan Sykora, Jan Brezovsky, Zbynek Prokop, 2014, Nature chemical biology.

Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization

Jan Brezovsky, Pavel Vanacek, Zbynek Prokop, 2018 .

Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity

Jan Brezovsky, Eva Sebestova, Jiri Damborsky, 2017, Chembiochem : a European journal of chemical biology.

Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering.

Yuji Nagata, Jan Brezovsky, Zbynek Prokop, 2010, Angewandte Chemie.