Steve D. M. Brown

Steve D. M. Brown, A. Ryan, Jian-Dong Li, 2013, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

N-ethyl-N-Nitrosourea (ENU) Induced Mutations within the Klotho Gene Lead to Ectopic Calcification and Reduced Lifespan in Mouse Models

Steve D. M. Brown, M. Brown, R. Cox, 2015, PloS one.

Panel 1: Biotechnology, biomedical engineering and new models of otitis media.

Steve D. M. Brown, T. Valdez, A. Schilder, 2019, International journal of pediatric otorhinolaryngology.

Transcript Analysis Reveals a Hypoxic Inflammatory Environment in Human Chronic Otitis Media With Effusion

Steve D. M. Brown, G. Nicholson, M. Cheeseman, 2020, Frontiers in Genetics.

The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse Chromosomes 11 and 6

Steve D. M. Brown, D. O’Carroll, T. Jenuwein, 1999, Mammalian Genome.

A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis

Steve D. M. Brown, M. Brown, R. Cox, 2012, PloS one.

Corrigendum: High-throughput discovery of novel developmental phenotypes

Steve D. M. Brown, Jacqueline K. White, Mark W. Moore, 2017, Nature.

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

Steve D. M. Brown, Ian C. Gray, Zuzanna Tymowska-Lalanne, 2000, Nature Genetics.

Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media

Steve D. M. Brown, D. Hood, Hilda Tateossian, 2020, Frontiers in Genetics.

The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Steve D. M. Brown, Hilda Tateossian, Oana Kubinyecz, 2020, Frontiers in Genetics.

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways

Steve D. M. Brown, A. Mallon, S. Wells, 2017, PLoS genetics.

Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis

Steve D. M. Brown, R. Cox, L. Greensmith, 2014, Brain : a journal of neurology.

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation

Steve D. M. Brown, M. Brown, A. Boyde, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen.

Steve D. M. Brown, Jennifer R. Davies, G. Mirza, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The homeobox gene Emx2 underlies middle ear and inner ear defects in the deaf mouse mutant pardon

Steve D. M. Brown, K. Steel, N. Spurr, 2003, Journal of neurocytology.

Large numbers of mice established by in vitro fertilization with cryopreserved spermatozoa: implications and applications for genetic resource banks, mutagenesis screens, and mouse backcrosses

Steve D. M. Brown, P. Glenister, C. Thornton, 1999, Mammalian Genome.

IDENTIFICATION OF NOVEL MOUSE MODELS OF CARDIOVASCULAR DEVELOPMENTAL MALFORMATIONS USING ETHYLNITROSOUREA MUTAGENESIS

Steve D. M. Brown, S. Neubauer, K. Clarke, 2009 .

α-Synuclein impairs macroautophagy: implications for Parkinson's disease

Steve D. M. Brown, D. Rubinsztein, B. Ravikumar, 2010 .

Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages

Steve D. M. Brown, S. Wells, R. Cox, 2010, Laboratory animals.

Novel phenotypes identified by plasma biochemical screening in the mouse

Steve D. M. Brown, S. Rastan, E. Fisher, 2002, Mammalian Genome.

PRIME importance of pathology expertise

Steve D. M. Brown, C. McKerlie, M. Warren, 2009, Nature Biotechnology.

Dyneins, Autophagy, Aggregation and Neurodegeneration

Steve D. M. Brown, D. Rubinsztein, B. Ravikumar, 2005, Autophagy.

Panel 3: Genetics and Precision Medicine of Otitis Media

Steve D. M. Brown, Jian-Dong Li, D. Preciado, 2017, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11

Steve D. M. Brown, M. Farrall, A. Goel, 2017, Scientific Reports.

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice

Steve D. M. Brown, S. Joyce, A. Parker, 2010, Mammalian Genome.

Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study.

Steve D. M. Brown, S. Rich, D. Bowden, 2006, Archives of otolaryngology--head & neck surgery.

INFRAFRONTIER quality principles in systemic phenotyping

Steve D. M. Brown, A. Flenniken, Y. Hérault, 2021, Mammalian genome : official journal of the International Mammalian Genome Society.

Mapping of the human and murine X11-like genes (APBA2 and Apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein

Steve D. M. Brown, G. Blanco, Christopher C. J. Miller, 1998, Mammalian Genome.

Ikzf2/helios is a key transcriptional regulator of outer hair cell maturation

Steve D. M. Brown, Michael C. Kelly, Maggie S. Matern, 2018, Nature.

Cellular content plays a crucial role in Non‐typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear

Steve D. M. Brown, D. Hood, Pratik P Vikhe, 2018, Cellular microbiology.

HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants

Steve D. M. Brown, S. Wells, T. Hough, 2011, PLoS genetics.

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse

Steve D. M. Brown, S. Wells, M. Cheeseman, 2016, Disease Models & Mechanisms.

A new model for NTHi middle ear infection in the Junbo mutant mouse

Steve D. M. Brown, S. Wells, M. Cheeseman, 2016 .

α-synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology

Steve D. M. Brown, J. Lucas, D. Rubinsztein, 2012, Autophagy.

Defective myosin VIIA gene responsible for Usher syndrome type IB

Steve D. M. Brown, K. Steel, A. Munnich, 1995, Nature.

DMM021659 69..79

Steve D. M. Brown, S. Wells, M. Cheeseman, 2016 .

µMRI–HREM pipeline for high‐throughput, high‐resolution phenotyping of murine embryos

Kieran Clarke, Steve D. M. Brown, Stefan Neubauer, 2007, Journal of anatomy.

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

Steve D. M. Brown, David G. Melvin, N. Karp, 2012, Mammalian Genome.

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment

Steve D. M. Brown, A. Parker, Rachel E Hardisty-Hughes, 2010, Nature Protocols.

Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis

Steve D. M. Brown, A. Mallon, S. Wells, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

An N‐Ethyl‐N‐Nitrosourea (ENU)‐Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice

Steve D. M. Brown, A. Mallon, S. Wells, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Regulatory Variation at Glypican-3 Underlies a Major Growth QTL in Mice

Steve D. M. Brown, P. Keightley, P. Denny, 2005, PLoS biology.

Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse

Steve D. M. Brown, E. Fisher, K. Steel, 2003, Current Biology.

Novel ENU-induced eye mutations in the mouse: models for human eye disease.

Steve D. M. Brown, S. Cross, I. Jackson, 2002, Human molecular genetics.

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

Steve D. M. Brown, Steve D.M. Brown, Mark Strivens, 2000, Mammalian Genome.

Genetic analysis of the mouse brain proteome

Kai Stühler, Martin Blüggel, Katrin Marcus, 2002, Nature Genetics.

IGF-1 receptor antagonism inhibits autophagy

Steve D. M. Brown, D. Rubinsztein, B. Ravikumar, 2013, Human molecular genetics.

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

Steve D. M. Brown, Mark W. Moore, 2012, Mammalian Genome.

Mutations in the myosin VIIA gene cause non-syndromic recessive deafness

Steve D. M. Brown, K. Steel, P. Mburu, 1997, Nature Genetics.

Mutagenesis strategies for identifying novel loci associated with disease phenotypes.

Steve D. M. Brown, R. Hardisty, Steve D. M. Brown, 2003, Seminars in cell & developmental biology.

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

Steve D. M. Brown, R. Mott, S. Wells, 2016, Nature Genetics.

Cellular Immune Response against Nontypeable Haemophilus influenzae Infecting the Preinflamed Middle Ear of the Junbo Mouse

Steve D. M. Brown, D. Hood, Pratik P Vikhe, 2019, Infection and Immunity.

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Paul Flicek, Steve D. M. Brown, Hiroshi Masuya, 2018, Nature Communications.

Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells

Steve D. M. Brown, D. Corey, K. Alagramam, 2013, The Journal of Neuroscience.

Quiet as a mouse: dissecting the molecular and genetic basis of hearing

Steve D. M. Brown, P. Mburu, Rachel E Hardisty-Hughes, 2008, Nature Reviews Genetics.

Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population

Steve D. M. Brown, S. Jacobson, X. Liu, 2005, Human Genetics.

The dark genome and pleiotropy: challenges for precision medicine

Steve D. M. Brown, H. Lad, Steve D. M. Brown, 2019, Mammalian Genome.

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Steve D. M. Brown, S. Cross, S. Greenaway, 2016, Nature Communications.

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival

Steve D. M. Brown, P. Avan, S. Picaud, 2017, EMBO molecular medicine.

Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31.

Steve D. M. Brown, A. Park, P. Mathur, 2015, Human molecular genetics.

Focusing on the genetics of hearing: you ain't heard nothin' yet

Steve D. M. Brown, Nick Parkinson, 2002, Genome Biology.

Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.

John M. Hancock, Steve D. M. Brown, Ann-Marie Mallon, 2004, Genome research.

Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

Steve D. M. Brown, D. Keays, J. Flint, 2007, Cell.

Rodent models of genetic disease.

Steve D. M. Brown, R. Cox, Steve D. M. Brown, 2003, Current opinion in genetics & development.

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Henrik Westerberg, John M. Hancock, Steve D. M. Brown, 2013, Genome Biology.

Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle

Steve D. M. Brown, G. Blanco, A. Greenfield, 2004, Neuromuscular Disorders.

Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5

Steve D. M. Brown, F. Ashcroft, R. Cox, 2013, PloS one.

Analysis of mammalian gene function through broad based phenotypic screens across a consortium of mouse clinics

Henrik Westerberg, John M. Hancock, Oliver Eickelberg, 2015, Nature Genetics.

Applying the ARRIVE Guidelines to an In Vivo Database

Steve D. M. Brown, Julius O. B. Jacobsen, Jacqueline K. White, 2015, PLoS biology.

Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources.

Werner Müller, John M. Hancock, George Kollias, 2007, Mammalian genome : official journal of the International Mammalian Genome Society.

Advances in mouse genetics for the study of human disease

Steve D. M. Brown, Steve D. M. Brown, 2021, Human molecular genetics.

An in vitro model of murine middle ear epithelium

Steve D. M. Brown, J. Stewart, K. Akram, 2016, Disease Models & Mechanisms.

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Steve D. M. Brown, Abraham Acevedo-Arozena, D. Rubinsztein, 2010, Human molecular genetics.

ENU mutagenesis, a way forward to understand gene function.

Steve D. M. Brown, Sara Wells, Abraham Acevedo-Arozena, 2008, Annual review of genomics and human genetics.

The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype

Steve D. M. Brown, S. Cross, I. Jackson, 2010, Human molecular genetics.

Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media

Steve D. M. Brown, Y. Hérault, M. Cheeseman, 2013, Mammalian Genome.

Functional annotation of the mouse genome: the challenge of phenotyping

Steve D. M. Brown, 2006 .

All systems GO for understanding mouse gene function

Steve D. M. Brown, C. Holmes, 2004, Journal of biology.

Precision medicine: Look to the mice.

Steve D. M. Brown, Mark W. Moore, A. Beaudet, 2015, Science.

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

Steve D. M. Brown, S. Greenaway, A. Mallon, 2020, BMC genomics.

A YAC-based physical map of the mouse genome

Steve D. M. Brown, B. Birren, C. Nusbaum, 1999, Nature Genetics.

A resource of targeted mutant mouse lines for 5,061 genes

Steve D. M. Brown, Diana L. Young, Jennie R. Green, 2019, bioRxiv.

Unraveling the genetics of otitis media: from mouse to human and back again

Steve D. M. Brown, J. Blackwell, S. Jamieson, 2011, Mammalian Genome.

Regulation of TGF-β signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant

Steve D. M. Brown, Hilda Tateossian, C. Dean, 2009, PathoGenetics.

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

Steve D. M. Brown, Jesse C. Werth, J. Sellers, 2021, bioRxiv.

Autosomal dominant non-syndromic deafness caused by a mutation in the myosin VIIA gene

Steve D. M. Brown, K. Steel, X. Liu, 1997, Nature Genetics.

Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse

Steve D. M. Brown, Jennifer R. Davies, M. Strivens, 2001, Mammalian Genome.

LAMA: automated image analysis for the developmental phenotyping of mouse embryos

Steve D. M. Brown, A. Mallon, S. Wells, 2021, Development.

LAMA: Automated image analysis for developmental phenotyping of mouse embryos

Henrik Westerberg, Steve D. M. Brown, Ann-Marie Mallon, 2020, bioRxiv.

Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy

Steve D. M. Brown, S. Rastan, E. Fisher, 2000 .

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Henrik Westerberg, John M. Hancock, Steve D. M. Brown, 2013, Genome Biology.

Mouse Models of NMNAT 1-Leber Congenital Amaurosis ( LCA 9 ) Recapitulate Key Features of 77 78 79 80 81 82 the Human Disease

Steve D. M. Brown, M. Krebs, Scott H. Greenwald, 2016 .

Dynein mutations impair autophagic clearance of aggregate-prone proteins

Steve D. M. Brown, D. Rubinsztein, B. Ravikumar, 2005, Nature Genetics.

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.

Steve D. M. Brown, J. Ragoussis, A. Prat, 2008, Genes & development.

Pcsk5in mice with mutation in the proprotein convertase VACTERL/caudal regression/Currarino syndrome-like

Steve D. M. Brown, A. Prat, N. Seidah, 2008 .

5 malformations in mice with mutation in the proprotein convertase VACTERL / caudal regression / Currarino syndrome-like data

Steve D. M. Brown, J. Ragoussis, A. Prat, 2008 .

A radiation hybrid map of mouse genes

Steve D. M. Brown, E. Lander, D. Church, 2001, Nature Genetics.

Genetic mapping of the whirler mutation

Steve D. M. Brown, K. Steel, P. Mburu, 1999, Mammalian Genome.

Reducing Igf-1r Levels Leads To Paradoxical and Sexually Dimorphic Effects in HD Mice

Steve D. M. Brown, D. Rubinsztein, M. Renna, 2014, PloS one.

Comparative gene mapping workshop: progress in agriculturally important animals

Steve D. M. Brown, Martine Yerle, Steve Brown, 2000, Mammalian Genome.

N‐ethyl‐N‐nitrosourea–Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss‐of‐Function Mice

Steve D. M. Brown, S. Wells, R. Cox, 2017, JBMR plus.

A gene-driven approach to the identification of ENU mutants in the mouse

Steve D. M. Brown, R. Cox, P. Glenister, 2002, Nature Genetics.

Identification of genes required for eye development by high-throughput screening of mouse knockouts

Steve D. M. Brown, Jacqueline K. White, Bret A. Moore, 2018, Communications Biology.

Three Novel Pigmentation Mutants Generated by Genome-Wide Random ENU Mutagenesis in the Mouse

Steve D. M. Brown, S. Rastan, E. Fisher, 2004, Comparative and functional genomics.

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity

Steve D. M. Brown, Thomas M. Keane, Iain M. Dykes, 2018, Scientific Reports.

Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background

Steve D. M. Brown, C. Scudamore, P. Potter, 2019, Scientific Reports.

Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels

Heng Li, Klaudia Walter, Steve D. M. Brown, 2009, Genome Biology.

Genomics meets genetics: towards a mutant map of the mouse

Steve D. M. Brown, C. Wells, 2000, Mammalian Genome.

The Deaf Mouse Mutant Jeff (Jf) is a Single Gene Model of Otitis Media

Steve D. M. Brown, K. Steel, R. Hardisty, 2003, Journal of the Association for Research in Otolaryngology.

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

Damian Smedley, Paul Flicek, Steve D. M. Brown, 2018, Conservation Genetics.

High-throughput discovery of genetic determinants of circadian misalignment

Steve D. M. Brown, A. Flenniken, M. Angelis, 2020, PLoS genetics.

Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function

Steve D. M. Brown, Stuart L. Johnson, S. Wells, 2019, EMBO molecular medicine.

A gene-driven ENU-based approach to generating an allelic series in any gene

Steve D. M. Brown, Roger D. Cox, Andy Greenfield, 2004, Mammalian Genome.

α-Synuclein levels modulate Huntington's disease in mice.

Steve D. M. Brown, D. Rubinsztein, M. Renna, 2012, Human molecular genetics.

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity*

Steve D. M. Brown, S. Tucker, M. D’Adamo, 2010, The Journal of Biological Chemistry.

A Mouse Model of Early-Onset Renal Failure Due to a Xanthine Dehydrogenase Nonsense Mutation

Steve D. M. Brown, M. Brown, R. Cox, 2012, PloS one.

Learning in Mice with a Poin

Steve D. M. Brown, C. A. French, J. Rawlins, 2022 .

Impaired Synaptic Plasticity and Motor t Mutation Implicated in Human Speech Deficits

Steve D. M. Brown, C. A. French, J. Rawlins, 2022 .

Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss

Steve D. M. Brown, Stuart L. Johnson, S. Wells, 2016, The Journal of Neuroscience.

Ikzf2/helios is a key transcriptional regulator of outer hair cell maturation

Steve D. M. Brown, Michael C. Kelly, Maggie S. Matern, 2018, Nature.

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Steve D. M. Brown, G. P. Sinha, R. Fettiplace, 2017, Nature Communications.

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Steve D. M. Brown, Jacqueline K. White, Elif F. Acar, 2020, PLoS genetics.

Steve D. M. Brown, Stuart L. Johnson, S. Wells, 2020, The Journal of physiology.

Gene-environment interactions differentially affect mouse strain behavioral parameters

Valter Tucci, Steve D. M. Brown, Steve D.M. Brown, 2006, Mammalian Genome.

A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse

Steve D. M. Brown, K. Davies, P. Oliver, 2003, The Journal of Neuroscience.

Protein 4.1 expression in the developing hair cells of the mouse inner ear

Steve D. M. Brown, P. Mburu, Y. Kikkawa, 2010, Brain Research.

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

Steve D. M. Brown, A. Mallon, S. Wells, 2016, Genome Medicine.

Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea

Steve D. M. Brown, Stuart L. Johnson, J. Jeng, 2020, The Journal of physiology.

The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells

Steve D. M. Brown, Stuart L. Johnson, P. Mburu, 2014, PloS one.

Gelsolin Plays a Role in the Actin Polymerization Complex of Hair Cell Stereocilia

Steve D. M. Brown, P. Mburu, Y. Kikkawa, 2010, PloS one.

Whirlin complexes with p55 at the stereocilia tip during hair cell development.

Steve D. M. Brown, P. Mburu, Y. Kikkawa, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

Steve D. M. Brown, M. Cheeseman, D. Hood, 2018, Scientific Reports.

13-P138 Regulation of TGF beta signalling by Fbxo11, the gene mutated in the Jeff Otitis Media mouse mutant

Steve D. M. Brown, Hilda Tateossian, C. Dean, 2009, Mechanisms of Development.

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.

Steve D. M. Brown, P. Mburu, Y. Kikkawa, 2005, Human molecular genetics.

Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

Steve D. M. Brown, D. Keays, J. Flint, 2007, Cell.

Identification of a new Pmp22 mouse mutant and trafficking analysis of a Pmp22 allelic series suggesting that protein aggregates may be protective in Pmp22-associated peripheral neuropathy.

Steve D. M. Brown, K. Davies, P. Oliver, 2003, Molecular and cellular neurosciences.

ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis

Steve D. M. Brown, K. Steel, J. Guénet, 2002, Mammalian Genome.

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Steve D. M. Brown, Jacqueline K. White, Bret A. Moore, 2018, Nature Communications.

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Steve D. M. Brown, Jacqueline K. White, Juan J. Gallegos, 2018 .

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Steve D. M. Brown, D. Rubinsztein, B. Ravikumar, 2010, The Journal of cell biology.

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity

Steve D. M. Brown, Thomas M. Keane, Iain M. Dykes, 2018, Scientific Reports.

Integration of Mouse Phenome Data Resources The Mouse Phenotype Database Integration Consortium *

John M. Hancock, Steve D. M. Brown, David G. Melvin, 2007 .

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

Steve D. M. Brown, M. Cheeseman, D. Hood, 2018, Scientific Reports.