Hein J. Wijma

发表

Computationally Efficient and Accurate Enantioselectivity Modeling by Clusters of Molecular Dynamics Simulations

Siewert J. Marrink, Hein J. Wijma, Dick B. Janssen, 2014, J. Chem. Inf. Model..

Computational library design and screening: Creating elephant paths in enzyme evolution

Hein J. Wijma, Dick B. Janssen, 2017 .

Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue

Marco W. Fraaije, Hein J. Wijma, Dick B. Janssen, 2014, FEBS open bio.

Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase

Ben L. Feringa, Hein J. Wijma, Dick B. Janssen, 2016 .

Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

Enantioselective enzymes by computational design and in silico screening.

David Baker, Siewert J Marrink, Hein J Wijma, 2015, Angewandte Chemie.

Stabilizing AqdC, a Pseudomonas Quinolone Signal‐Cleaving Dioxygenase from Mycobacteria, by FRESCO‐Based Protein Engineering

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

Computational Library Design for Increasing Haloalkane Dehalogenase Stability

Hein J. Wijma, B. Feringa, D. Janssen, 2014, Chembiochem : a European journal of chemical biology.

Computationally designed libraries for rapid enzyme stabilization

Hein J. Wijma, David Baker, D. Janssen, 2014, Protein engineering, design & selection : PEDS.

Bidirectional catalysis by copper-containing nitrite reductase.

Hein J. Wijma, S. de Vries, H. Wijma, 2004, Biochemistry.

Computational redesign of enzymes for regio- and enantioselective hydroamination

Hein J. Wijma, D. Janssen, H. Wijma, 2018, Nature Chemical Biology.

Computational design gains momentum in enzyme catalysis engineering

Hein J Wijma, Dick B Janssen, Hein J. Wijma, 2013, The FEBS journal.

Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin

Hein J. Wijma, D. Janssen, H. Wijma, 2022, ACS catalysis.

From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase

Hein J. Wijma, D. Janssen, H. Wijma, 2021, Computational and structural biotechnology journal.

Protein engineering of amine transaminases

Hein J. Wijma, D. Janssen, H. Wijma, 2022, Frontiers in Catalysis.

Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design

Hein J. Wijma, H. Wijma, M. Fraaije, 2018, Biotechnology for Biofuels.

Metabolism of β-valine via a CoA-dependent ammonia lyase pathway

Hein J. Wijma, D. Janssen, H. Wijma, 2015, Applied Microbiology and Biotechnology.

Aminoacyl‐coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum

Hein J. Wijma, D. Janssen, H. Wijma, 2011, FEBS letters.

Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor

Hein J. Wijma, Matthias Heinemann, A. Schmidt, 2019, bioRxiv.

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering**

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate and Protein Engineering

Hein J. Wijma, D. Janssen, H. Wijma, 2020, bioRxiv.

Efficient Enzymatic Cyclization of Disulfide‐Rich Peptides by Using Peptide Ligases

Hein J. Wijma, D. Craik, D. Janssen, 2019, Chembiochem : a European journal of chemical biology.

Exploring the Gating Mechanisms of Aquaglyceroporins: New Clues for Inhibitor’s Design?

Hein J. Wijma, A. Casini, M. Loureiro-Dias, 2016 .

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.

Hein J. Wijma, D. Janssen, H. Wijma, 2023, The FEBS journal.

Substrate Induced Movement of the Metal Cofactor between Active and Resting State

Hein J. Wijma, D. Svergun, L. Mestrom, 2022, Angewandte Chemie.

Thermodynamics Determine the Diastereochemical Outcome of Catalytic Reactions

Hein J. Wijma, H. Wijma, L. Mestrom, 2021, ChemCatChem.

A conserved sequence motif in the Escherichia coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency

Hein J. Wijma, H. Wijma, M. Fraaije, 2022, The Journal of biological chemistry.

In silico screening of enzyme variants by molecular dynamics simulation

Hein J. Wijma, H. Wijma, 2016 .

Structure- and sequence-analysis inspired engineering of proteins for enhanced thermostability.

Hein J. Wijma, Robert J. Floor, Dick B. Janssen, 2013, Current Opinion in Structural Biology.

Computational design gains momentum in enzyme catalysis engineering

Hein J. Wijma, D. Janssen, 2013, The FEBS journal.

Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus

Hein J. Wijma, B. Feringa, D. Janssen, 2012, Applied and Environmental Microbiology.

University of Groningen Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus Crismaru,

Hein J. Wijma, B. Feringa, D. Janssen, 2013 .

Identiﬁcation and characterization of archaeal and bacterial F 420 -dependent thioredoxin reductases

Hein J. Wijma, M. L. Mascotti, Guang Yang, 2022 .

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

Hein J. Wijma, D. Janssen, B. Dijkstra, 2013, Chembiochem : a European journal of chemical biology.

A Random-sequential Mechanism for Nitrite Binding and Active Site Reduction in Copper-containing Nitrite Reductase*

Hein J. Wijma, H. Wijma, F. Armstrong, 2006, Journal of Biological Chemistry.

Characterization of two bacterial multi-flavinylated proteins harboring multiple covalent flavin cofactors

Hein J. Wijma, H. Wijma, H. Rozeboom, 2023, BBA advances.

Peptide C-terminal modification using a computationally stabilized peptide amidase

Hein J. Wijma, B. Feringa, D. Janssen, 2018 .

Directed Evolution Strategies for Enantiocomplementary Haloalkane Dehalogenases: From Chemical Waste to Enantiopure Building Blocks

Hein J Wijma, Dick B Janssen, Hein J. Wijma, 2012, Chembiochem : a European journal of chemical biology.

Kinetic Resolution of α-Bromoamides: Experimental and Theoretical Investigation of Highly Enantioselective Reactions Catalyzed by Haloalkane Dehalogenases

Hein J. Wijma, B. Feringa, D. Janssen, 2011 .

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Hein J. Wijma, D. Janssen, S. Marrink, 2021, ACS catalysis.

A robust cosolvent-compatible halohydrin dehalogenase by computational library design

Hein J. Wijma, D. Janssen, H. Wijma, 2016, Protein engineering, design & selection : PEDS.

X‐ray crystallographic validation of structure predictions used in computational design for protein stabilization

Hein J Wijma, Dick B Janssen, Hein J. Wijma, 2015, Proteins.

Part I: Structure‐ and sequence‐analysis inspired engineering of proteins for enhanced thermostability

Hein J. Wijma, 2015 .

BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B

Hein J. Wijma, H. Wijma, M. Fraaije, 2012 .

Real-Time Conformational Changes and Controlled Orientation of Native Proteins Inside a Protein Nanoreactor

Hein J. Wijma, B. Poolman, H. Wijma, 2017, Journal of the American Chemical Society.

Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor

Hein J. Wijma, H. Rozeboom, Yapei Tong, 2023, Journal of the American Chemical Society.

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.

Hein J. Wijma, D. Janssen, H. Wijma, 2018, Organic & biomolecular chemistry.

Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation.

Hein J. Wijma, H. Wijma, F. Armstrong, 2007, Journal of the American Chemical Society.

A photo-switchable yeast isocitrate dehydrogenase to control metabolic flux through the citric acid cycle

Hein J. Wijma, Matthias Heinemann, H. Wijma, 2021, bioRxiv.

A Computational Library Design Protocol for Rapid Improvement of Protein Stability: FRESCO.

Maximilian J L J Fürst, Hein J. Wijma, D. Janssen, 2017, Methods in molecular biology.

BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Metabolism of β-valine via a CoA-dependent ammonia lyase pathway

Hein J. Wijma, D. Janssen, W. Szymański, 2015 .

Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase.

Hein J. Wijma, B. Feringa, D. Janssen, 2010, Chemical communications.

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

Hein J. Wijma, D. Janssen, H. Wijma, 2020, ACS catalysis.

A rearranging ligand enables allosteric control of catalytic activity in copper-containing nitrite reductase.

Hein J. Wijma, M. Murphy, H. Wijma, 2006, Journal of molecular biology.

Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion.

Hein J. Wijma, M. Murphy, H. Wijma, 2003, Biochemistry.

Catalytic and structural properties of ATP‐dependent caprolactamase from Pseudomonas jessenii

Hein J. Wijma, Clemens Mayer, D. Janssen, 2020, Proteins.

Peptide esterification by SbPam: studies on organic solvent stability and thermostability

Hein J. Wijma, D. Janssen, H. Wijma, 2018 .

Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase.

Hein J. Wijma, H. Rozeboom, G. Poelarends, 2024, The FEBS journal.

Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

Hein J. Wijma, A. Casini, H. Wijma, 2016, Molecular bioSystems.

Asymmetric Synthesis of Optically Pure Aliphatic Amines with an Engineered Robust ω-Transaminase

Hein J. Wijma, D. Janssen, S. Marrink, 2020, Catalysts.

University of Groningen Asymmetric Synthesis of Optically Pure Aliphatic Amines with an Engineered Robust omega-

Hein J. Wijma, D. Janssen, S. Marrink, 2020 .