Maurice Dickins

发表

Application of PBPK modelling in drug discovery and development at Pfizer

Kuresh Youdim, Hannah M Jones, Maurice Dickins, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

The importance of predictive ADME simulation.

Maurice Dickins, Sandeep Modi, 2002, Drug discovery today.

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.

Alex Phipps, R Scott Obach, Maurice Dickins, 2008, British journal of clinical pharmacology.

Simulation models for drug disposition and drug interactions

Han van de Waterbeemd, Maurice Dickins, H. Waterbeemd, 2004 .

Quantitative structure–activity relationships (QSARs) in CYP3A4 inhibitors: The importance of lipophilic character and hydrogen bonding

Maurice Dickins, D. Lewis, B. Lake, 2006, Journal of enzyme inhibition and medicinal chemistry.

Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms

Alex Phipps, Maurice Dickins, Tanya L Hay, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Genetically Engineered Cell Lines: Characterisation and Applications in Toxicity Testing

Walter Luyten, Daniel A. Casciano, Maurice Dickins, 1997 .

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

Hannah M Jones, Maurice Dickins, Barry C Jones, 2011, Clinical pharmacokinetics.

Quantitative Structure-Activity Relationships (QSARs) Within Series of Inhibitors for Mammalian Cytochromes P450 (CYPs)

Maurice Dickins, D. Lewis, M. Dickins, 2001, Journal of enzyme inhibition.

Structure–activity relationship for human cytochrome P450 substrates and inhibitors

David F. V. Lewis, Maurice Dickins, D. Lewis, 2002, Drug metabolism reviews.

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

Maurice Dickins, Iain Gardner, Hannah M. Jones, 2008 .

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

Alex Phipps, Kuresh Youdim, Maurice Dickins, 2009, Drug Metabolism and Disposition.

Advances in in vitro drug metabolism screening

Peter J. Eddershaw, Maurice Dickins, P. Eddershaw, 1999 .

Maraviroc: in vitro assessment of drug-drug interaction potential.

Maurice Dickins, Claire Collins, B. Jones, 2008, British journal of clinical pharmacology.

Substrate SARs in human P450s.

Maurice Dickins, D. Lewis, David F V Lewis, 2002, Drug discovery today.

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

Hugh A Barton, Hannah M Jones, Maurice Dickins, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Compound lipophilicity for substrate binding to human P450s in drug metabolism.

Maurice Dickins, Miriam N Jacobs, D. Lewis, 2004, Drug discovery today.